Senior Bioinformatics Specialist

6 days ago

Oxford, Oxfordshire, United Kingdom Northreach Full time
Job Overview

Northreach is a dynamic recruitment agency that connects businesses with top talent in the Advanced Therapies sector. Our mission is to provide a seamless and personalized recruitment experience for clients and candidates, and to create a positive work environment that encourages equality, innovation, and professional growth.

**Company Background**

Our client is a pioneering biotechnology company that specializes in the development of innovative therapies for various diseases. They have a strong focus on antigen modulation through the inhibition of ERAP enzymes, which play a critical role in the antigen presentation pathway.

**Job Summary**

The Senior Bioinformatics Specialist will play a key role in the conceptualization, design, and implementation of innovative data analysis strategies to advance the company's ERAP1 inhibitor-driven antigen discovery pipeline. The successful candidate will analyze extensive proprietary datasets, including immunopeptidomic, transcriptomic, and genomic data, to identify ERAP1 inhibitor-dependent targets for the development of MHC class I therapeutics.

**Key Responsibilities**

  • Develop and maintain high-quality nextflow pipelines for processing large-scale mass spectrometry data.
  • Define objectives and perform statistical analysis of data-dependent (DDA) and data-independent (DIA) immunopeptidomics assays.
  • Conduct analysis of parallel reaction monitoring (PRM) peptide assays.
  • Integrate antigen discovery workflows with transcriptomic and genomic data.
  • Leverage external resources and databases to enhance internal workflows and improve target prioritization.
  • Stay at the forefront of scientific advances in mass spectrometry-based immunopeptidomics and antigen presentation, including software and new methodologies.
  • Lead and manage analytical aspects of projects, including data preparation, analysis, and visualization.
  • Provide data-driven insights to inform experimental design.
  • Communicate research findings to both technical and non-technical audiences, internally and externally.

**Support Functions**

  • Act as a key member of the multidisciplinary core team to contribute to the company's overarching goals.
  • Participate in strategic discussions related to bioinformatics in R&D.
  • Assist in generating presentation materials for external communications.

**Additional Responsibilities**

  • Demonstrate leadership by adhering to and promoting company policies, including data security protocols.
  • Complete all required GXP/SOP training and comply with relevant SOP requirements.
  • Uphold and embody the company's values.

**Requirements**

  • PhD (or equivalent experience) in bioinformatics, immunology, computational biology, or a related field.
  • In-depth knowledge of mass spectrometry-based proteomics data acquisition and processing, with familiarity in data-dependent and data-independent methods preferred.
  • Strong knowledge of machine learning and/or multivariate statistical modeling.
  • Proficiency in statistical programming and building statistical models.
  • Expertise in R or Python programming.
  • Extensive experience in large-scale bioinformatics analysis of omics data.
  • Proficient in Linux OS and shell scripting.
  • Experience with building and running analytical pipelines using NextFlow and Docker.
  • Ability to analyze, interpret, and record findings efficiently and in compliance with standards.
  • Strong communication skills, capable of conveying complex topics to diverse audiences.
  • Proven success working in multidisciplinary scientific teams (desirable).
  • Familiarity with cloud infrastructure (e.g., AWS) is a plus.
  • Deep understanding of antigen processing (desirable).
  • Prior research experience in an industrial setting (desirable).
  • Knowledge of molecular biology, cell biology, or immunology (desirable).

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