Senior Scientist, Structural Biology Expert

5 days ago

Cambridge, Cambridgeshire, United Kingdom Bicycle Therapeutics Full time
Job Opportunity: Senior Scientist, Structural Biology

Bicycle Therapeutics is a pioneering pharmaceutical company dedicated to developing innovative medicines for underserved diseases. Our team is seeking a highly skilled Senior Scientist to join our Structural Biology department, where you will play a crucial role in obtaining high-quality protein structural data to drive drug discovery programs.

As a Senior Scientist, you will employ X-ray protein crystallography and Cryo-electron microscopy (CryoEM) methods to furnish insights into target biology and map protein-ligand interactions. You will work closely with cross-functional project teams to generate impactful structural data that drives project success and scientific publications.

Key responsibilities include:

  • Driving structural biology-related activities of Discovery programs
  • Solving protein structures employing Protein crystallography or CryoEM methods
  • Critical interpretation and presentation of structural data to internal and external project teams
  • Working closely with computational and medicinal chemists to enable structure-guided Bicycle designs
  • Validating biochemical data relevant for structure determination and target-specific assays

Requirements:

  • Educated structural biology or equivalent qualification/experience
  • Expertise in X-ray crystallography or Cryo-electron microscopy (CryoEM)
  • Capable of independently designing and safely executing wet lab experiments
  • Experience in biochemical and biophysical characterization of proteins, specifically in construct design and sample quality evaluation
  • Experience of working in a pharmaceutical/biotechnology/drug discovery setting
  • Experience using software/computational methods to aid structure-based drug design

Bicycle Therapeutics offers a dynamic and collaborative work environment, with a strong focus on innovation and scientific excellence. We provide a competitive reward package, including annual company bonus, employee recognition schemes, and a range of benefits to support your well-being and career development.

We are committed to building a diverse workforce that reflects the communities we serve. We recognize that diverse and inclusive teams build a stronger and more innovative company. Therefore, all qualified applicants will be considered for employment, and we do not discriminate on the basis of race, religion, colour, gender, sexual orientation, age, disability status, marital status, or veteran status.

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