Chemical Project Director

5 days ago

Slough, Slough, United Kingdom Lifelancer Ltd Full time
About the Role

We are seeking a highly experienced and skilled Chemical Project Director to join our team at Lifelancer Ltd. As a key member of our research and development department, you will be responsible for leading projects from early discovery to clinical phases, ensuring the successful development of new compounds.

Key Responsibilities
  • Project Leadership: Design and execute experimental studies, collaborate with cross-functional teams to deliver data and interpretations, and drive projects towards candidate selection and beyond.
  • Expertise in DMPK: Possess a deep understanding of preclinical pharmacokinetics, toxicokinetics, nonclinical safety, PKPD, PK modeling, drug design, clinical DMPK, bioanalytics, and biomarkers.
  • Compound Design: Apply knowledge of physical properties, DMPK, and enzymology to inform the design of new compounds.
  • Collaboration and Communication: Work with project and development sciences colleagues to resolve or risk-mitigate project-related ADME challenges, and champion new approaches to project support.
  • Document Preparation: Prepare DMPK sections of internal and regulatory documents, including IND, IMPD, IB, and NDA.
  • Research and Publication: Participate in research aligned to DMPK and UCB's portfolio, and publish research papers in internationally recognized journals.
  • Mentorship: Provide scientific mentorship to support junior staff in their personal development.
Requirements
  • Education and Experience: PhD (or equivalent) in Pharmaceutics, Pharmacology, Drug metabolism, or Pharmacokinetics, with 7 years of post-doctoral industrial experience, or a related degree with 10 years industrial experience in DMPK science.
  • Comprehensive Understanding: Possess a comprehensive understanding of discovery and development DMPK, including modeling and simulation, and a proven ability to delineate the impact of chemical structure on measured properties.
  • Regulatory Experience: Wide experience in pharmaceutical R&D, including knowledge of regulatory requirements and experience working with regulatory agencies to fulfill the DMPK contribution to new drug submissions.
  • Track Record: A recognized track record of experience in DMPK/ADME, excellent knowledge in ADME/Enzymology/Drug Transporters, and knowledge of how to couple data to optimization/selection of NCE, both in discovery and development.
  • Leadership and Expertise: Proven track record of leading, understanding, and hands-on experience of drug metabolism and pharmacokinetics, both in vitro and in vivo studies, human PK prediction, DDI prediction, and mechanistic understanding to support late-stage programs.
  • Additional Requirements: Understanding of PKPD and preferably an understanding of PBPK modeling, proven skills for in-depth mechanistic understanding of DMPK-related issues, and knowledge of the drug development processes in the Pharma Industry environment.

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