DMPK Group Leader

4 weeks ago

Scotland, United Kingdom Cancer Research UK Full time
About Cancer Research UK

Cancer Research UK is a world-leading charity dedicated to beating cancer through research, awareness, and support. Our mission is to create a future where all cancers are cured, and we're committed to making a difference in the lives of people affected by cancer.

Job Summary

We're seeking an experienced and accomplished scientific leader to join our Drug Discovery team as a DMPK Group Leader. As a key member of our team, you'll be responsible for leading and driving our DMPK and translational modelling strategy, working closely with our Medicinal Chemistry and DMPK group to deliver impactful insights across a range of challenging target classes.

Key Responsibilities
  • Design, propose, and execute innovative experiments that positively impact projects and the overall direction of in vitro/in vivo science.
  • Maintain awareness of external developments in the DMPK and PKPD fields, applying these to ongoing projects and proactively suggesting and evaluating new techniques.
  • Design and implement new ways of working that have a direct impact on data quality and productivity.
  • Contribute to the strategic leadership within the Medicinal Chemistry and DMPK group, as well as the overall Therapeutic Innovation research strategy.
  • Effectively manage outsourcing activities and prioritize and coordinate multiple areas of work.
  • Lead and drive a high-performing team to provide all aspects of DMPK and PKPD expertise.
  • Manage internal expertise, capacity, and resources to drive governance and decision-making regarding scientific portfolio support and technology development.
  • Communicate and share knowledge and expertise effectively within and across the organisation.
  • Present and clarify results across departments and to alliance partners.
  • Ensure a high level of data integrity within the DMPK group.
  • Lead drug discovery projects where appropriate.
  • Be a recognised and passionate leader, able to represent the department across a broad range of therapeutic projects and cross-site initiatives, both internally and externally.
  • Drive scientific and technical innovation, including through external collaboration and partnership.
  • Ensure equality and diversity is celebrated and considered as part of all decisions taken.
Requirements
  • PhD or equivalent experience in Pharmaceutics, Pharmacology, Drug metabolism, or Pharmacokinetics, encompassing a significant element of Modelling & Simulation.
  • Significant experience and deep expertise in DMPK aspects of drug discovery.
  • Proven track record of delivering PK, PKPD, and TKPD aspects to projects, including significant experience in translating drug-target kinetics through to mechanistic PKPD modelling for therapeutic dose prediction.
  • Expert in specialist tools such as MATLAB, SimCYP, WinNonLin/Phoenix NLME.
  • Strong external reputation in translational PKPD modelling and DMPK, evidenced through a wide personal network, external presentation, and publication in high-impact journals.
  • Excellent interpersonal and communication skills, coupled with strong leadership skills, ability to influence multiple stakeholders, and collaborate across projects and sites.
  • Significant experience in developing and leading a diverse world-class team, whilst working in a highly matrixed discovery project environment.
  • Track record of delivering results across a diverse project portfolio by driving strategic and scientific initiatives.
  • Significant experience of establishing and leading external academic and industrial collaborations, and technology change projects.
  • Confidence and credibility to work at the intersection between mechanistic pharmacology, medicinal chemistry, computational chemistry & DMPK to define and prosecute strategies that deliver impactful insight across a range of challenging target classes, through to clinical dose prediction.
  • Future-orientated and strategic in thinking style.
What We Offer

Cancer Research UK offers a generous benefits package, a wide range of career and personal development opportunities, and high-quality tools, policies, and processes to enable you to do your job well. Our benefits package includes a substantial retirement plan, a generous and flexible leave allowance, discounts on anything from travel to technology, gym membership, and much more. We actively encourage a flexible working culture, and our work – from funding cutting-edge research to developing public policy – will change the world. It's exciting to be part of our team.

How to Apply

We operate an anonymised shortlisting process in our commitment to equality, diversity, and inclusion. CVs are required for all applications; but we won't be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you quickly, fairly, and objectively. Please note: Cancer Research UK can consider visa sponsorship for this vacancy. If this applies to you, please ensure that this is clearly marked on your application.

  • DMPK Group Leader

    1 month ago

    Scotland, United Kingdom Cancer Research UK Full time

    About the RoleWe are seeking an accomplished scientific and people leader to lead and drive our DMPK and translational modelling strategy as we start to implement our new 5-year plan.Key ResponsibilitiesDesign, propose and execute innovative experiments which positively impact projects and the overall direction of in vitro/in vivo science.Maintain awareness...

  • DMPK Group Leader

    1 month ago

    Scotland, United Kingdom Cancer Research UK Full time

    About the RoleWe are seeking an accomplished scientific and people leader to lead and drive our DMPK and translational modelling strategy as we start to implement our new 5-year plan.Key ResponsibilitiesDesign, propose and execute innovative experiments which positively impact projects and the overall direction of in vitro/in vivo science.Maintain awareness...

  • DMPK Group Leader

    3 weeks ago

    Scotland, United Kingdom Cancer Research UK Full time

    About the RoleCancer Research UK is seeking an experienced DMPK Group Leader to join our Drug Discovery team. As a key member of our team, you will be responsible for leading and driving our DMPK and translational modelling strategy.Key ResponsibilitiesDesign, propose and execute innovative experiments to positively impact projects and the overall direction...

  • DMPK Group Leader

    3 weeks ago

    Scotland, United Kingdom Cancer Research UK Full time

    About the RoleCancer Research UK is seeking an experienced DMPK Group Leader to join our Drug Discovery team. As a key member of our team, you will be responsible for leading and driving our DMPK and translational modelling strategy.Key ResponsibilitiesDesign, propose and execute innovative experiments to positively impact projects and the overall direction...

  • Clinical Nurse Leader

    2 weeks ago

    Scotland, United Kingdom Randolph Hill Nursing Homes Group Full time

    Job Title: Clinical Nurse LeaderWe are seeking an experienced Clinical Nurse Leader to join our team at Randolph Hill Nursing Homes Group. As a Clinical Nurse Leader, you will be responsible for providing high-quality nursing care to our residents while leading and managing a team of nurses.Key Responsibilities:Provide professional clinical nursing to all...

  • Clinical Nurse Leader

    2 weeks ago

    Scotland, United Kingdom Randolph Hill Nursing Homes Group Full time

    Job SummaryWe are seeking a highly skilled and compassionate Registered Nurse to join our team at Randolph Hill Nursing Homes Group. As a Clinical Nurse Leader, you will be responsible for providing exceptional care to our residents while promoting a positive and supportive work environment.Key Responsibilities:Deliver high-quality nursing care to residents...

  • Production Team Leader

    2 weeks ago

    Scotland, United Kingdom Talento Group Full time

    Job Title:Production Team Leader - Food & Beverage IndustrySalary:Competitive, Up to £38k (DOE)Location:Dumfries, South ScotlandHours: 4 on 4 off (2 days, 2 nights, 4 off) - 12-Hour ShiftsAbout the Role:Talento Group is currently recruiting for an exciting Production Team Leader role at a leading food and beverage production facility in Dumfries. This is an...

  • Production Team Leader

    2 weeks ago

    Scotland, United Kingdom Talento Group Full time

    About the RoleTalento Group is seeking an experienced Production Team Leader to join our team at our Dumfries facility. As a Production Team Leader, you will be responsible for managing a shift, leading a team to meet production targets, and maintaining high-quality standards within the factory.Key ResponsibilitiesLead and manage your team to meet production...

  • Production Team Leader

    2 weeks ago

    Scotland, United Kingdom Talento Group Full time

    About the RoleTalento Group is seeking an experienced Production Team Leader to join our team at our Dumfries facility. As a Production Team Leader, you will be responsible for managing a shift, leading a team to meet production targets, and maintaining high-quality standards within the factory.Key ResponsibilitiesLead and manage your team to meet production...

  • Group Finance Risk Manager

    2 months ago

    Scotland,, UK, United Kingdom pawaTech Full time

    About the job:pawaTech Group is looking for a Group Finance Risk Manager with a strong background in financial crime investigation with an inherent passion for teamwork, a collaborative spirit, and a forensic mindset. As a Group Finance Risk Manager, you will ensure the integrity and efficiency of our financial operations, by designing and delivering a...

  • Senior Engineering Leader

    2 weeks ago

    Aberdeenshire, Scotland, United Kingdom Orion Group Full time

    Job DescriptionOrion Group is seeking a highly skilled Senior Engineering Leader to join our team. The successful candidate will be responsible for overseeing all engineering tasks, ensuring action, completion, and closure. They will manage the engineering team, supporting the technical requirements of the business, and oversee all engineering-related work...

  • Production Team Leader

    2 weeks ago

    Scotland, United Kingdom Talento Group Full time

    Job Title: Production Team Leader - Food & Beverage IndustrySalary: Competitive, Up to £38k (DOE)Location: Dumfries, South ScotlandHours: 4 on 4 off (2 days, 2 nights, 4 off) - 12-Hour ShiftsAbout the Role:Talento is currently recruiting for an excitingProduction Team Leaderrole at a leadingfood and beverage production facilityinDumfries. This is an...

  • Mechanical Engineer Leader

    2 weeks ago

    Scotland, United Kingdom AtkinsRéalis Full time

    About the RoleWe are seeking a highly skilled and experienced Mechanical Engineer to join our team as a leader. As a Senior Mechanical Engineer, you will be responsible for supervising, developing, and mentoring others, as well as leading technical aspects of mechanical engineering projects.Key ResponsibilitiesSupervise and develop junior engineers,...

  • Mechanical Engineer Leader

    2 weeks ago

    Scotland, United Kingdom AtkinsRéalis Full time

    About the RoleWe are seeking a highly skilled and experienced Mechanical Engineer to join our team as a leader. As a Senior Mechanical Engineer, you will be responsible for supervising, developing, and mentoring others, as well as leading technical aspects of mechanical engineering projects.Key ResponsibilitiesSupervise and develop junior engineers,...

  • Tour Leader

    2 weeks ago

    Scotland, United Kingdom G Adventures Full time

    About UsG Adventures is a world-renowned small-group adventure travel company that has been crafting unforgettable travel experiences for over 30 years. Our mission is to change lives through travel, fostering meaningful relationships with local communities and promoting sustainable tourism practices.As a Chief Experience Officer (CEO) with G Adventures, you...

  • Youth Ministry Leader

    2 weeks ago

    Scotland, United Kingdom Scripture Union Scotland Full time

    Job Title: Youth Ministry LeaderThis role involves leading a cross-departmental approach to training and discipleship in relation to young people. The successful candidate will work with a wide range of colleagues to ensure opportunities for intentional discipleship continue to grow and develop in all aspects of SU Scotland's ministry.Key...

  • Senior Ecologist Leader

    2 weeks ago

    Scotland, United Kingdom Ecus Ltd Full time

    Establish a new team in Scotland and make a positive impact within the Cura Terrae group.With a long history of presence in Scotland, the Cura Terra group have an established network of clients and positive reputation leading to exciting new opportunities for working partnerships.This is an exciting opportunity to lead a team to success with a...

  • Export & Customer Services Team Leader

    5 months ago

    Scotland, United Kingdom Orion Full time

    **Job description**: Export & Customer Services Team Leader Competitive salary and extensive benefits package Permanent role - Hybrid role Location - Perth, Scotland Our client, a successful Global Engineering Manufacturing business are seeking to appoint an experienced Export & Customer Service Team Leader to oversee a team of Customer Service/Export...

  • Senior Nurse Leader

    3 weeks ago

    Scotland, United Kingdom Healthcare Improvement Scotland Full time

    Senior Nurse Leadership OpportunityWe are seeking a highly experienced and skilled Senior Nurse to join our team at Healthcare Improvement Scotland.As a key member of our Senior Management Team, you will provide senior level professional leadership and advice across the organisation and externally with partners in NHS Boards, education and professional and...

  • Senior Nurse Leader

    3 weeks ago

    Scotland, United Kingdom Healthcare Improvement Scotland Full time

    Senior Nurse Leadership OpportunityWe are seeking a highly experienced and skilled Senior Nurse to join our team at Healthcare Improvement Scotland.As a key member of our Senior Management Team, you will provide senior level professional leadership and advice across the organisation and externally with partners in NHS Boards, education and professional and...