DMPK Group Leader

1 month ago

Scotland, United Kingdom Cancer Research UK Full time
About the Role

We are seeking an accomplished scientific and people leader to lead and drive our DMPK and translational modelling strategy as we start to implement our new 5-year plan.

Key Responsibilities
  • Design, propose and execute innovative experiments which positively impact projects and the overall direction of in vitro/in vivo science.
  • Maintain awareness of external developments in the DMPK and PKPD fields, the application of these to on-going projects and proactively suggest and evaluate new techniques.
  • Design and implement new ways of working that have a direct impact on data quality and productivity.
  • Contribute to the strategic leadership within the Medicinal Chemistry and DMPK group, as well as the overall Therapeutic Innovation research strategy.
  • Effectively manage appropriate outsourcing activities.
  • Effectively prioritise and co-ordinates multiple areas of work.
  • Lead and drive a high-performing team to provide all aspects of DMPK and PKPD expertise.
  • Manage internal expertise, capacity, and resources to drive governance and decision-making regarding scientific portfolio support and technology development.
  • Communicate and share knowledge and expertise effectively within and across the organisation.
  • Present and clarify results across departments and to alliance partners.
  • Ensure a high level of data integrity within DMPK group.
  • Lead drug discovery projects where appropriate.
  • Be a recognised and passionate leader, able to represent the department across a broad range of therapeutic projects and cross-site initiatives, both internally as well as externally.
  • Drive scientific and technical innovation, including through external collaboration and partnership.
  • Ensure equality and diversity is celebrated and considered as part of all decisions taken.
Requirements
  • PhD or equivalent experience in Pharmaceutics, Pharmacology, Drug metabolism or Pharmacokinetics encompassing a significant element of Modelling & Simulation, such as quantitative pharmacology, systems biology, pharmacometrics, applied mathematics
  • Significant experience and deep expertise in DMPK aspects of drug discovery
  • Proven track record of delivering PK, PKPD and TKPD aspects to projects, including significant experience in translating drug-target kinetics through to mechanistic PKPD modelling for therapeutic dose prediction
  • Expert in specialist tools such as MATLAB, SimCYP, WinNonLin/Phoenix NLME.
  • Strong external reputation in translational PKPD modelling and DMPK, evidenced through wide personal network, external presentation, and publication in high-impact journals
  • Excellent interpersonal and communication skills coupled with strong leadership skills, ability to influence multiple stakeholders and collaborate across projects and sites
  • Significant experience in developing and leading a diverse world-class team, whilst working in a highly matrixed discovery project environment.
  • Track record of delivering results across a diverse project portfolio by driving strategic and scientific initiatives
  • Significant experience of establishing and leading external academic and industrial collaborations, and technology change projects
  • Confidence and credibility to work at the intersection between mechanistic pharmacology, medicinal chemistry, computational chemistry & DMPK to define and prosecute strategies that deliver impactful insight across a range of challenging target classes, through to clinical dose prediction
  • Future-orientated and strategic in thinking style
What We Offer

Every one of our employees contributes to our progress and is supporting our work to beat cancer. We think that's impressive.

In return, we make sure you are supported by a generous benefits package, a wide range of career and personal development opportunities and high-quality tools, policies, and processes to enable you to do your job well.

Our benefits package includes a substantial retirement plan, a generous and flexible leave allowance, discounts on anything from travel to technology, gym membership, and much more.

We don't forget people have lives outside of work too and so we actively encourage a flexible working culture.

Our work – from funding cutting-edge research to developing public policy – will change the world. It's exciting to be part of our team.

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