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Research Scientist
2 months ago
About the Company:
CK Group is working in partnership with Nxera Pharmato recruit a Research Scientist/Senior Scientist, to join the Protein Engineering group based at our research facility.
About the Role:
We are seeking an experienced molecular biologist to join the Protein Engineering group at our research facility, working on facilitating GPCR structure determination to enable drug discovery efforts.
Responsibilities:
- Construct engineering to facilitate the expression of wild-type and mutant GPCRs in cells.
- Characterisation of GPCRs in cells, membranes and in detergent-solubilised form, using ligand binding and signalling assays.
- Establishing and optimising thermal stability assays.
- Development of novel technologies for accelerating structure determination of GPCRs.
- Working closely with a diverse group of scientists across the Platform division and the broader drug discovery organisation to advance projects.
Requirements:
- A PhD (or a Masters, plus at least 3 years of laboratory experience) in a relevant area of molecular biology/biochemistry.
- Expertise in a variety of cloning techniques.
- Proficiency in cell culture.
- Substantial experience in assay development and optimisation.
- Experience of carrying out GPCR ligand binding and signalling assays.
- Previously worked with detergent-solubilised GPCRs or other membrane proteins.
- A strong understanding of membrane protein structure and function.
- The ability to work flexibly within a team, whilst being highly self-motivated and able to work independently.
- Analytical thinking and good problem-solving skills.
- Excellent organisational, communication and time-management skills, including the ability to work to deadlines.
What's in it for you?
- A state-of-the-art R&D centre located in the heart of the Cambridge science cluster.
- A competitive compensation package including discretionary cash bonuses.
- Eligibility for grants of Restricted Stock Units.
- 25 days annual leave in addition to public holidays plus the option to purchase an additional 5 days each year.
- Employer contribution to pension.
- Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement.
- Health and wellbeing benefits including a subsidised individual gym membership.
- Income protection to cover long-term absences due to ill health.
- Group Death in Service equal to 4x basic annual salary.
