RNA Sample Preparation Manager

3 weeks ago

Oxford, Oxfordshire, United Kingdom Oxford Nanopore Technologies Full time

Company Overview

Oxford Nanopore Technologies is a pioneering organization located at the forefront of scientific innovation, with a global presence that spans various regions including the US, APAC, and Europe.

Our team comprises experts from diverse fields such as nanopore technology, molecular biology, informatics, engineering, and commercial development. Under the leadership of CEO Dr. Gordon Sanghera, we have a proven history of introducing groundbreaking technologies to the market.

Our unique sequencing platform is distinguished by its capability for real-time analysis across scalable formats, enabling the examination of native DNA or RNA and accommodating fragment lengths from short to ultra-long. Our mission is to facilitate the analysis of any biological entity, accessible to anyone, anywhere.

Position Overview

We are seeking a dedicated RNA Sample Preparation Manager to become a vital part of our RNA/cDNA Sample Technologies team. This full-time, laboratory-based role focuses on the research and development of our sequencing kits, aimed at improving the efficacy of RNA/cDNA sequencing processes, platforms, and comprehensive workflows for biopharmaceutical applications utilizing our innovative technologies.

The successful candidate will report to the Director of the RNA/cDNA Sample Technologies division and will be responsible for:

  • Designing experiments and conducting offline assays, library preparation, and RNA/cDNA sequencing to create and refine sample preparation kits and protocols.
  • Providing data and insights to bioinformatics teams to enhance the design of end-to-end workflows.
  • Communicating findings effectively to relevant stakeholders and maintaining oversight of key research initiatives.

Key Responsibilities

The role encompasses a variety of duties, including but not limited to:

  • Conducting experimental design and implementing enhancements for RNA/cDNA sequencing protocols and kits, including methodologies for direct RNA and cDNA sequencing.
  • Extracting and preparing nucleic acids for RNA and/or DNA sequencing.
  • Developing and maintaining specific assays and protocols, such as RNA/cDNA sequencing sample preparation, transcriptome sequencing, barcoding, and sequence capture/enrichment.
  • Generating sequencing data for subsequent bioinformatic analysis.
  • Collaborating with bioinformatics and software development teams to ensure the provision of necessary sequencing data aligned with experimental designs.
  • Documenting experimental findings and writing protocols for publication.
  • Generating and curating quality control data and sequencing data to support the development of sample preparation methodologies.
  • Ensuring methodologies comply with quality standards and regulatory practices.
  • Assisting new team members with laboratory work and basic bioinformatics tasks.

Candidate Profile

The ideal candidate will possess a postgraduate Ph.D. degree and postdoctoral experience in a molecular biology or biotechnology-related field, along with several years of relevant industry experience, preferably in RNA-related disciplines. A successful track record in laboratory-based academic research or pertinent lab experience, coupled with an understanding of next-generation sequencing, is essential.

We expect candidates to demonstrate knowledge, skills, and abilities in the following areas:

  • Fundamental understanding of nucleic acid structure and function, with hands-on experience working with RNA.
  • Basic data analysis and statistical skills.
  • Familiarity with standard molecular biology laboratory techniques such as gel electrophoresis and PCR/qPCR.
  • Ability to perform essential laboratory calculations.
  • Strong organizational, interpersonal, and communication skills.
  • Previous managerial experience is highly desirable.

This position is ideal for an enthusiastic individual with robust problem-solving and communication skills, capable of thriving in multidisciplinary teams while also working independently.

Benefits

We offer a comprehensive benefits package, including an attractive bonus structure, generous pension contributions, private healthcare, and a competitive starting salary. Our work environment is enhanced by beautiful, landscaped surroundings, providing a pleasant atmosphere for our team.

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