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PhD Research Scientist
2 months ago
We are seeking a highly motivated and experienced PhD Research Scientist to join our Cell Biology team. As a key member of our team, you will be responsible for designing and troubleshooting assays to examine the binding of TCR bispecific molecules to cells, the activation of T cells, and T-cell mediated killing.
Key Responsibilities:
- Design and conduct experimental work to align with company priorities and meet scientific timelines.
- Collaborate effectively with other research functions, such as Protein Engineering and CMC teams, to guide optimisation and development of soluble TCRs.
- Dissect molecular mechanisms of T cell activation and T cell mediated killing by soluble TCR bispecific molecules.
- Drive innovation and continuous improvement within the Cell Biology team, implementing novel technologies, workflows, and methodologies to enhance productivity and accelerate the drug development process.
- Present scientific findings and summary conclusions to your department, project team, and company leadership team.
Requirements:
- Familiarity with a range of cell and molecular biology techniques, such as flow cytometry analysis, T cell assays, killing assays, cytokine assays, designing and executing recombinant DNA sub-cloning strategies, making lentiviral supernatants, lentiviral transduction.
- Direct hands-on laboratory experience in testing and developing of biologics, including the assessment of the biological impact of their engagement with therapeutic targets.
- Experience leading projects, overseeing the experimental strategy, and coordinating the work of other team members.
- A PhD in a relevant biological subject with or without post-doctoral experience in academia and/or with substantial subsequent biotechnology or pharmaceutical industry experience in R&D teams.
- Ability to independently lead programmes to advance the company's goals, review competing priorities, and recommend strategies to advance the programme.
- Inclusive, collaborative, and thrives in a team environment with a flexible approach to working.
- Strong communication skills with the confidence and judgement to challenge appropriately.
- Demonstrable problem-solving ability, creative thinking, and be pro-active in driving the project forwards.
