Scientific Researcher

2 weeks ago

Cambridge, United Kingdom MRC Laboratory of Molecular Biology Full time

To work within the group of Dr Ingo Greger at the MRC Laboratory of Molecular Biology (LMB), on a programme aimed at studying the modulation of AMPA glutamate receptor/auxiliary subunit complexes by small-molecule therapeutics. Specifically, the post holder will work in close collaboration with Astra Zeneca to investigate the auxiliary subunit-selective interaction with modulatory drugs. This will involve protein expression in mammalian and insect cells, screening of drug libraries at AZ and cryo-EM analysis of suitable hit compounds; see (Herguedas et al., Science 2016 & 2019; Dohrke et al., JBC 2020; Zhang et al., Nature 2021 & 2023; Zhang et al., Nature Comms. 2023).

**Main duties**:

- To undertake research aimed at determining AMPAR cryo-EM structures associated with therapeutic ligands.
- To present scientific work at seminars within the laboratory and at external meetings.
- To contribute to laboratory-wide discussions on developments within the field.
- Where appropriate, to draft scientific papers, and contribute to the overall preparation of research for publication.
- To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care.
- To assist in the training of PhD students and other members of the LMB.

**Key responsibilities**:
To plan your own work and objectives and manage your experimental work within the project along with your Supervisor.

To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.

To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.

**Working relationships**:
You will report to Dr Ingo Greger and will interact and collaborate with other Postdoctoral Scientists, Research Support staff and students, not only in your group, but also across the LMB and with external groups as necessary.
- Person Specification 1
- **Academic qualifications**:
**Technical skills and expertise**:
Experience of and ability to perform techniques relevant to the project. Essential will be expertise with cryo-EM. Particularly useful would be experience with membrane protein biochemistry, mammalian and insect cell culture.

**Track record of research**:
This will include achievements, and contributions to published papers.

**Other relevant evidence of**:

- Commitment.
- Originality.
- Ability to communicate.
- Working with others.

**Additional information**:
This is a great opportunity to work at the forefront of structural analysis of ligand-gated ion channels by cryo-EM in collaboration with the pharmaceutical industry.
- Further Information 1
- **Corporate/ Local responsibilities & requirements**
You must at all times carry out your responsibilities with due regard to the UKRI:

- Code of Conduct
- Equality, Diversity and Inclusion policy
- Health and Safety policy
- Data Protection policy

Job descriptions should be reviewed on a regular basis and at the annual appraisal. Any changes should be made and agreed between you and your manager.

The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post, the MRC and UKRI.

The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment.
- The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration opportunities that the MRC name brings. The MRC is an excellent place to develop yourself further and a range of training & development opportunities will be available to you, including professional registration with the Science Council.
- Choosing to come to work at the MRC (part of UKRI) means that you will have access to a whole host of benefits from a defined benefit pension scheme and excellent holiday entitlement to access to employee shopping/travel discounts and salary sacrifice cycle to work scheme, as well as the chance to put the MRC and UKRI on your CV in the future.

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