Associate Director, Drug Discovery Toxicologist

2 weeks ago

Oxford, United Kingdom Exscientia Full time

**About Us**

Exscientia is an AI-driven pharmatech company committed to discovering, designing and developing the best possible drugs in the fastest and most effective manner. Exscientia developed the first-ever functional precision oncology platform to successfully guide treatment selection and improve patient outcomes in a prospective interventional clinical study, as well as to progress AI-designed small molecules into the clinical setting.

**The Role**

Please note this is a hybrid role but occasional travel may be required to our offices in Vienna (AT) or Oxford (UK) (approximately 1-2 times per quarter), with flexibility to work from home the remaining time.

**You will have the opportunity to**:

- Represent Toxicology as the Subject Matter Expert on cross-functional project teams within the Discovery organisation. Opportunity to represent Toxicology in Development as the projects progress.
- Act as a key resource for early safety assessment during the drug discovery phase, providing scientific knowledge and expertise to cross-functional project teams.
- Use established toxicology screening strategies to predict, assess and mitigate target
- and drug-related safety risks in support of the drug discovery portfolio.
- Refine and implement innovative experimental strategies and use the data to assess and /or provide mechanistic understanding of safety issues.
- Collaborate with CROs to ensure best practice for in vitro and/or in vivo safety assessment.
- Prepare verbal and written summaries for internal discussions. Work with the Discovery teams to develop optimal strategies to address specific safety issues within project teams. Present summary data to project teams, Exscientia senior leadership and external partners as needed.

**Requirements**:
**Essential skills**:

- DVM, Pharm D, Ph.D in toxicology, Pathology, Physiology, Biochemistry or expertise in related biological scientific disciplines, with an emphasis on Oncology/Immunology is preferred. 10+ years’ experience in safety sciences in the Biotech/Pharma industry
- Experience in project team membership as a Discovery toxicology representative in a matrix environment
- Experience with in silico and in vitro safety assessment leading to an in-depth knowledge of discovery toxicology, and experience designing and critically evaluating results of exploratory toxicology studies
- An understanding of in vitro to in vivo translation of potential toxicities and implications for human safety
- Broad background in novel methods of identifying potential toxicities and developing risk mitigation plans
- Highly motivated scientist, who can work independently, with excellent oral/written communication skills

**Desirable skills**:

- Board Certification in Toxicology (DABT/ERT)
- Experience running in vivo safety assessment studies
- Knowledge of secondary pharmacology assessment and mitigation of identified risks

**Benefits**
- Work together to make a positive contribution to patients by revolutionising the pharmaceutical industry through AI-driven discovery
- Opportunity to join an inclusive, collaborative and intellectually stimulating culture
- We will work with you to provide a highly competitive compensation as we continue to grow and thrive
- Our team’s health and well-being is important to us we offer a generous holiday allowance, provide flexible working and remote working to encourage all of our team to manage their own work, time and life along with wellbeing and mindfulness support
- When you are in the office, you will have access to a kitchen stocked with an endless supply of food for all employees. Along with access plenty of break out areas so you can get to know the people you are working with. Some of the best ideas start with a coffee break
- Hear from our team why they enjoy working here.

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