Senior Research Scientist

1 month ago

Oxford Oxfordshire, United Kingdom Nucleome Full time

The Schrodinger Building, Oxford Science Park , Oxford
HOURS: Full-time
CONTRACT TYPE: Permanent
NUCLEOME THERAPEUTICS , a fast-growing biopharma that is building a passionate, creative, and dedicated multi-disciplinary team of scientists with expertise in gene regulation, genomics, machine learning, drug discovery, data analysis and software development, whose mission is to decode and mine the regulatory “dark matter” of the human genome to transform drug target discovery and deliver first-in-class precision medicine for autoimmune diseases. We are building a rewarding and fun environment where people embrace creative ways of thinking, take smart risks, and feel empowered to make a difference.
The drug discovery team are looking for a talented senior scientist with a background in cellular pharmacology in primary immune cells to support the progression into the pipeline of the early biologics drug targets emerging from Nucleome’s proprietary platform technology. In this lab-based role you will design and develop primary and secondary assays for evaluation of early biologics drug molecules, engage in mechanism of action studies and support the progression of multiple asset programmes in early drug discovery. You will design and develop assays to test therapeutic hypotheses, investigate the pharmacology of tool and candidate molecules, and characterise the biological impact of drug molecules in ‘on target’ and ‘off target’ cell types. Strong understanding of the principles of cellular immunology and pharmacology
Ability to design, execute and analyse cellular pharmacology experiments in primary immune cells independently.
PhD qualification in a relevant field (e.g., Research experience in an immunological disease therapeutic area.
Experience of analysing and presenting data using FlowJo and GraphPad Prism software.
Strong communication skills and ability to communicate complex ideas to specialists and non-specialists project and functional team meetings.
Flexible and co-operative approach to colleagues.
Ability to develop and improve new skills and knowledge necessary to successfully support assigned projects.
Strong organisational and time management skills to work on multiple projects simultaneously and prioritise and balance competing demands accordingly.
Ability to deliver high-quality, consistent results in a timely fashion.
Proficiency in laboratory techniques including Western blotting, immunohistochemistry and/or qPCR.
Experience in genetic manipulation assays CRISPR or RNA knockdown.
At Nucleome Therapeutics equality, diversity and inclusion is really important to us. We welcome applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.
Suite C, Second Floor, Schrodinger Building,
Oxford Science Park, Oxford, OX4 4GE
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