Bioinformatician - Cell Biology - Biological Mass

2 weeks ago


Cambridge, United Kingdom Medical Research Council Full time

**Open Date**
- 25/03/2024, 10:00

**Close Date**
- 29/04/2024, 23:55
- Research Institute 1- MRC Laboratory of Molecular Biology- Research Institute / Unit Information 1The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably protein crystallography, cryo-electron microscopy, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease. We aim to tackle difficult, long-term problems, which often require investment over many years.

There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. However, scientific collaboration between the different Divisions is extensive. Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute.

The LMB provides an unsurpassed environment for both new and established researchers. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation.- Band 1- MRC - 3/4- Location 1- Cambridge- Salary 1- Investigator Scientist: £41,843 - £43,962 per annum or Senior Scientist: £48,802 - £56,817 per annum- Contract Type 1- Permanent- Job Type 1- Science- Full Time / Part Time 1- Full or Part Time options- Job Description 1**_Investigator Scientist_**

**Overall purpose**:
To build, lead and manage bioinformatic pipelines in the Biological Mass Spectrometry and Proteomics Facility at the MRC Laboratory of Molecular Biology (LMB).

To work as part of a dynamic and collaborative team of facility staff, with research groups in the LMB, and with other bioinformatics experts within LMB. Specifically, to develop and maintain analysis methods and pipelines to analyse data produced by cutting-edge mass spectrometry technologies. These will include the analysis of datasets produced by high throughput labelled and label free proteomics, analysis of protein interactions in the context of hydrogen/deuterium exchange, purified protein complexes or in-cell interactions using crosslinking mass spectrometry.

To develop and implement new analysis software packages in line with the strategic development of the Facility and of the LMB overall.

To communicate data analysis results obtained with users of the Biological Mass Spectrometry and Proteomics Facility

To be a focus of expertise on Mass Spectrometry/Proteomics bioinformatics.

**Main duties**:

- Analyse and share insights derived from mass spectrometry/proteomics projects with the users of the LMB Biological Mass Spectrometry Facility while also accommodating further analysis requests.
- Work together with the Facility Head to understand and meet the facility users goals and advise in the appropriate experimental design to ensure high-quality data analysis.
- Build customised data analysis pipelines for high throughput proteomics and for protein structural analysis by crosslinking and hydrogen-deuterium exchange mass spectrometry, based on analysis needs.
- Communicate results with the facility users using reproducible data analysis and reporting strategies aided by appropriate data visualisations.
- Lead development of analysis solutions where the current needs are unmet.
- Manage the analysis of multiple projects simultaneously and provide progress updates, in line with the facility's vision.
- Keep up to date with developments in the field, proposing or implementing changes of direction as necessary.
- Contribute to the overall preparation of research for publication through data analysis and production of relevant figures.
- To train students, postdoctoral scientists and others where appropriate.
- To lead and implement proteomic/mass spectrometry data analysis training workshops aimed at the diverse LMB community (students, Postdoctoral Scientist and others).
- To contribute to the MRC's engagement with the public and in the translation of research findings into improvements in health care.
- To present your work at seminars within the laboratory and at external meetings.

**Key responsibilities**:
The key responsibility is to undertake bioinformatic analysis of cutting-edge research, aimed at key questions within the remit of the different research groups that use the Biological Mass Spectrometry Facility within the LMB. You will be expected to provide the intellectual energy and independent thinking necessary to deliver the analysis and to play a major role in shaping the overall aims.

You will be expected to have the skill and understanding to be able to act independently in solving problems, many of which may require novel approaches. This will require the integration of


  • Bioinformatician

    2 weeks ago


    Cambridge, United Kingdom MRC Laboratory of Molecular Biology Full time

    To build, lead and manage bioinformatic pipelines in the Biological Mass Spectrometry and Proteomics Facility at the MRC Laboratory of Molecular Biology (LMB). To work as part of a dynamic and collaborative team of facility staff, with research groups in the LMB, and with other bioinformatics experts within LMB. Specifically, to develop and maintain...

  • Bioinformatician

    3 weeks ago


    Cambridge, United Kingdom TEC PARTNERS LIMITED Full time

    At TEC Partners we are extremely excited to be recruiting for a client who has grown exponentially over the last 12 months, due to this they are looking to add a talented Bioinformatician to join their award-winning team. This is a rare opportunity to joina well-established company who are at the forefront of cutting-edge Biological Research. **What your...


  • Cambridge, United Kingdom University of Cambridge Full time

    **Join our team as a Bioinformatician!** The McGovern lab is seeking a talented and motivated Bioinformatics Research Associate to join their research group. Our research aims to understand how mononuclear phagocyte biology is altered in disease. **The McGovern Lab**: Our team focuses on characterising human mononuclear phagocytes, crucial immune cells...


  • Cambridge, United Kingdom Hays Specialist Recruitment Limited Full time

    Join an exciting start-up immune-oncology biotech. Junior Bioinformatician - Cambridge - Salary up to £40 000. **Your new company** Join an exciting an innovative immune-oncology start-up biotech with a focus on developing innovative cancer medicines by targeting macrophage biology. **Your new role** Our client are looking for a junior bioinformatician to...


  • Cambridge, United Kingdom Taylorollinson ltd Full time

    **Cell Biologist - Gene Delivery** **Location**:Cambridge **Contract**:Full-time and permanent **Sector**:Biotechnology / Drug Discovery **Salary**:£26,000 - £30,000 Our client is an innovative biotechnology company based outside of the centre of Cambridge. They have built a platform to synthesis DNA which provides exciting possibilities for ensuring...


  • Cambridge, United Kingdom MRC Laboratory of Molecular Biology Full time

    Fixed-term, 3 years Applications are invited for a Postdoctoral Scientist position in the laboratory of Dr Ramanujan Hegde at the MRC Laboratory of Molecular Biology (LMB). The role is to work within a programme aimed at understanding the molecular mechanisms of protein maturation, quality control, and protein misfolding diseases. Specifically, to undertake...


  • Cambridge, United Kingdom MRC Laboratory of Molecular Biology Full time

    Fixed-term, 3 years Applications are invited for a Postdoctoral Scientist position in the laboratory of Dr Ramanujan Hegde at the MRC Laboratory of Molecular Biology (LMB). The role is to work within a programme aimed at understanding the molecular mechanisms of protein maturation, quality control, and protein misfolding diseases. Specifically, to undertake...


  • Cambridge, United Kingdom University of Cambridge Full time

    The core bioinformatics group at the Gurdon Institute, University of Cambridge is recruiting a Senior Bioinformatician to extend our capabilities in delivering world class research into developmental biology. Our group supports researchers across the institute in experimental design, analysis and presentation of high throughput data. You will work...


  • Cambridge, Cambridgeshire, United Kingdom University of Cambridge Full time

    We are seeking a talented Bioinformatician to join the Spatial Profiling and Annotation Centre of Excellence (SPACE), led by Prof. Gregory Hannon and Dr. Dario Bressan, at the CRUK Cambridge Institute, University of Cambridge. This role involves analysing and integrating single-cell and spatial transcriptomic and proteomic data across various cancer types,...


  • Cambridge, Cambridgeshire, United Kingdom University of Cambridge Full time

    We are seeking a talented Bioinformatician to join the Spatial Profiling and Annotation Centre of Excellence (SPACE), led by Prof. Gregory Hannon and Dr. Dario Bressan, at the CRUK Cambridge Institute, University of Cambridge. This role involves analysing and integrating single-cell and spatial transcriptomic and proteomic data across various cancer types,...


  • Cambridge, Cambridgeshire, United Kingdom University of Cambridge Full time

    The core bioinformatics group at the Gurdon Institute, University of Cambridge is recruiting a Senior Bioinformatician to extend our capabilities in delivering world class research into developmental biology.Our group supports researchers across the institute in experimental design, analysis and presentation of high throughput data. You will work...


  • Cambridge, United Kingdom Cancer Research UK Cambridge Institute Full time

    We are seeking a talented Bioinformatician to join the Spatial Profiling and Annotation Centre of Excellence (SPACE), led by Prof. Gregory Hannon and Dr. Dario Bressan, at the CRUK Cambridge Institute, University of Cambridge. This role involves analysing and integrating single-cell and spatial transcriptomic and proteomic data across various cancer types,...


  • Cambridge, Cambridgeshire, United Kingdom clock.bio Full time

    Position: Lead Computational Biologist / Bioinformatician Location: The Milner Therapeutics Institute, Cambridge, UK (hybrid position, at most 50% remote) Type: Full-Time As the shared risk factor of the deadliest diseases, the process of ageing forms the core of our focus. As a fast-paced biotech startup, we are looking for a Lead Computational...


  • Cambridge, Cambridgeshire, United Kingdom clock.bio Full time

    Position: Lead Computational Biologist / Bioinformatician Location: The Milner Therapeutics Institute, Cambridge, UK (hybrid position, at most 50% remote) Type: Full-Time As the shared risk factor of the deadliest diseases, the process of ageing forms the core of our focus. As a fast-paced biotech startup, we are looking for a Lead Computational...


  • Cambridge, United Kingdom clock.bio Full time

    Position: Lead Computational Biologist / BioinformaticianDo not pass up this chance, apply quickly if your experience and skills match what is in the following description.Location: The Milner Therapeutics Institute, Cambridge, UK (hybrid position, at most 50% remote)Type: Full-TimeAbout clock.bioAt clock.bio, we believe that ageing, while natural, is not...


  • Cambridge, United Kingdom University of Cambridge Full time

    The core bioinformatics group at the Gurdon Institute, University of Cambridge is recruiting a Senior Bioinformatician to extend our capabilities in delivering world class research into developmental biology. Our group supports researchers across the institute in experimental design, analysis and presentation of high throughput data. You will work...


  • Cambridge, United Kingdom Astex Pharmaceuticals Full time

    **The Role** You will be part of a team that includes bioinformaticians, biologists, computational chemists and structural biologists. There will be opportunities for research into novel methods including machine learning based approaches. **Principal Responsibilities**: - Support ongoing drug discovery projects e.g. assessment of potential selectivity...


  • Cambridge, United Kingdom clock.bio Full time

    Position: Lead Computational Biologist / Bioinformatician Location: The Milner Therapeutics Institute, Cambridge, UK (hybrid position, at most 50% remote) Type: Full-Time About clock.bio At clock.bio, we believe that ageing, while natural, is not inevitable. As the shared risk factor of the deadliest diseases, the process of ageing forms the core of our...


  • Cambridge, United Kingdom clock.bio Full time

    Position: Lead Computational Biologist / BioinformaticianLocation: The Milner Therapeutics Institute, Cambridge, UK (hybrid position, at most 50% remote)Type: Full-TimeFind out more about the daily tasks, overall responsibilities, and required experience for this opportunity by scrolling down now.About clock.bioAt clock.bio, we believe that ageing, while...


  • Cambridge, United Kingdom clock.bio Full time

    Position: Lead Computational Biologist / BioinformaticianLocation: The Milner Therapeutics Institute, Cambridge, UK (hybrid position, at most 50% remote)Type: Full-TimeAbout clock.bioAt clock.bio, we believe that ageing, while natural, is not inevitable. As the shared risk factor of the deadliest diseases, the process of ageing forms the core of our focus....