Research Associate
3 weeks ago
An exciting opportunity has emerged to join the Molecular Biophysics Group to work on a MNDA-supported collaborative project between the teams from Chemistry department and ISMIB of the University of Liverpool.
The project will benefit from collaboration with leading PROTAC expert at Dundee (Ciulli) and team at the Alzheimers Research UK UCL Drug Discovery Institute (ARUK UCL DDI) led by Fiona Ducotterd. We aim to provide novel scaffolds that bind to the as-yet unexploited validated pocket surrounding Trp32. We will investigate for the first time, a fragment-based approach to drug design targeted against destabilised superoxide dismutase mutant, causative agent of motor neuron disease. Direct crystallographic visualisation will be used to undertake lead optimisation and designing of CNS penetrant versions of initial small molecules hits. This non-covalent binding is suitable for a PROteolysis TArgeting Chimera (PROTAC) approach. In-cell visualisation of protein aggregation and cell death would be undertaken using laser-scanning confocal microscopy. You will be supported by the medicinal chemistry PDRA recruited for this project under Professor Paul O¿Neill. You will be responsible for the structural biology/biophysics/cell biology part of the project. Experience with various elements of a drug discovery structural biology project together with confocal microscopy for in-cell visualisation and tissue culture experience would be an advantage.
You should also be able to work in a team and previous experience of working at multiple sites would be an advantage. You will have an opportunity to spend a month per annum at the recently opened Centre for Targeted Protein Degradation at Dundee. Excellent verbal and written communication skills are essential.
You will have an MPhil in Biochemistry/Biophysics/Structural biology.
This post is available from 1 October 2023 until 30 September 2026
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Postdoctoral Research Associate
4 weeks ago
Liverpool, Liverpool, United Kingdom University of Liverpool Full timeThe NIHR has funded an innovative programme of research, led by Professor Sir Munir Pirmohamed, to personalise renal (kidney) function monitoring for patients with heart failure (RENAL-HF). This aims to change healthcare for thousands of patients with heart failure by reducing kidney damage, enabling them to live longer, healthier lives. Previously we have...
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Postdoctoral Research Associate in Applied
4 days ago
Liverpool, United Kingdom University of Liverpool Full timeApplications are invited for a Postdoctoral Research Associate position in the Department of Mathematics at the University of Liverpool. You will work under the supervision of Dr Andreas Alpers. The position is funded by Dr Alpers¿ E.P.S.R.C New Investigator Award project “Optimal Grain Diagrams: Mathematical Analysis and Algorithms”. You will...
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Research Associate/fellow
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Postdoctoral Research Associate
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Liverpool, United Kingdom University of Liverpool Full timeThe Department of Mathematical Sciences at the University of Liverpool is seeking a Postdoctoral Research Associate in the area of lattice field theory in the research cluster of Fundamental Particle Physics. You should have a PhD and a research track record in lattice field theory, quantum computing/simulation or related areas including publications in...
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Postdoctoral Research Associate
4 weeks ago
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Postdoctoral Research Associate
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Postdoctoral Research Associate in Advanced
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Post Doctoral Research Associate
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Research Associate in Data Science
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Liverpool, United Kingdom Liverpool John Moores University Full timeLiverpool John Moores University (LJMU) is a distinctive, unique institution, rooted in the Liverpool City Region and with a global presence. Our students and staff, past, present, and future, are the beating heart of our city and can be found in every corner of every industry and community. We couldn’t exist anywhere else and have shaped the city in which...
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Postdoctoral Research Associate in Chemistry
6 days ago
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Liverpool, United Kingdom University of Liverpool Full timeWe are seeking to recruit an individual to Join the prestigious Signal Processing Group at the University of Liverpool as a Senior Postdoctoral Research Associate, in Data Fusion. In this role, you will take the lead in addressing complex data fusion challenges through innovative research. Working closely with external partners, you¿ll guide and inspire the...
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Postdoctoral Research Associate
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Clinical Research Associate
2 weeks ago
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Research Associate
4 weeks ago
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Clinical Research Associate
2 days ago
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Liverpool, United Kingdom University of Liverpool Full timeAre you looking to advance your career in data science? The University of Liverpool¿s Signal Processing Group is currently seeking a Senior Postdoctoral Research Associate to join our vibrant team at the forefront of data science research. In this senior role, you will lead a team and drive ground-breaking projects that bridge the gap between academia and...
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Postdoctoral Research Associate in Ai and
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Post-doctoral Research Associate
2 weeks ago
Liverpool, United Kingdom Liverpool School of Tropical Medicine Full time**Reference**: **MAR20241667** - Expiry date: - 18:59, Sun, 17th Mar 2024- Location: - Liverpool- Salary: - £38,205.00 - £44,263.00 Per Annum- Benefits: - 30 Days holiday (pro rata) + Bank Holiday and additional Christmas closure days- Duration: - Fixed-term appointment to 31st January 2026**Salary: £38,205 - £44,263 per annum **_(starting salary will be...
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Postdoctoral Research Associate in AI
18 hours ago
Liverpool, Liverpool, United Kingdom University of Liverpool Full timeA Horizon Europe funded Postdoctoral Research Associate (PDRA) position is available at the Department of Eye and Vision Sciences and the Liverpool Centre for Cardiovascular Science (LCCS) at the University of Liverpool. You will join an ambitious EU-wide collaboration (TARGET: Health virtual twins for the personalised management of stroke related to atrial...