Research Associate

3 weeks ago


South Kensington, United Kingdom Imperial College London Full time

The Thurston Laboratory seeks an ambitious, passionate, and self-motivated Postdoctoral Research Associate to explore the host pathogen interactions that determine the outcome of bacterial infections as well as fundamental cell biology related to host immunity.

Virulence factors, termed effectors, which are delivered from the bacteria into the host, represent a key determinant of bacterial pathogenesis. Our group showed that one such protein SteE, drives macrophage polarisation after switching the amino acid and substrate specificity of a host serine/threonine kinase into a tyrosine kinase. Yet, it is not known if other examples of kinase reprogramming exist. We strive to decipher new examples of kinase reprogramming and new mechanisms that regulate anti-bacterial immune responses. Applications for a Postdoctoral Research Associate are therefore invited. This post is funded by the EPSRC after the award of an ERC Starting Grant.

The project will employ techniques at the molecular, microbiological, and cellular level and likely involve proteomics as well as the use of CrispR-cas9.

**Duties and responsibilities**:
You will be responsible for leading the research and should be willing to take the initiative in experimental design, execution, and data analysis.
- identify suitable methodologies for the collection and analysis of data
- ensure the validity and reliability of data
- use molecular biology, bacteriological and cellular biology approaches
- present findings to collaborators, colleagues, and at conferences
- submit findings for publication in refereed journals
- take initiative in the planning of research, with clear and timely communications to the Group Leader and relevant researchers.
- supervise both undergraduate and postgraduate research students.

**Essential requirements**:

- **Research associate**:You will have a PhD (or equivalent) in biochemistry, microbiology, cell biology, host-pathogen interactions and/or microbiology or a closely related discipline
- ** Research assistant**:Near completion of a PhD (or equivalent) in biochemistry, microbiology, cell biology, host-pathogen interactions and/or microbiology or a closely related discipline
- You will also have a strong track record, evidenced by publication of original scientific work in refereed journals.
- Experience in microbiology, class II pathogens, and host pathogen interactions
- Practical experience in general molecular microbiology approaches
- Practical experience in general molecular and cellular biology encompassing cloning, immunoblotting, flow cytometry, microscopy, and cell culture.
- Practical experience of proteomics

**Further information**:
**Documents**:

- Research-Associate - JD.pdf


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