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Research Associate, Ipsc

4 weeks ago

Edinburgh, United Kingdom Resolution Therapeutics Full time

**LOCATION**: Edinburgh, UK**:

- Job Type: Full time
- Start Date: ASAP
- Benefits: Our competitive package includes income protection, pension, private health insurance, and life assurance, as well as an opportunity to participate in the Company’s incentive shares scheme.

We are looking for an experienced **Research Associate **to join the fast-growing team within our **iPSC Biology **unit at our site in **Edinburgh** This position is a **full-**time** opportunity, on a **permanent** basis.

In this role, you will carry out scientific discovery work relating to iPSC-derived macrophages for therapeutic use in liver cirrhosis. You will report directly to the **Group Leader, iPSC Biology **and will collaborate closely with a Research Scientist within the same Induced Pluripotent Stem Cell unit.
- **Key Responsibilities**:

- iPSC culture and characterisation
- Develop and optimise protocols for macrophage differentiation
- Supporting the engineering of iPSCs and derived macrophages g., for hypo-immunogenicity, as well as introduction of phenotype enhancing payloads
- Supporting the scale-up efforts using multiple culturing formats
- Interfacing with the Cell Engineering, In Vivo Pharmacology, Translational and Macrophage Biology units to identify best-in-class iMACs products and collaborate on assay development, scale-up and _in vivo _studies
- Assisting with writing patents, publications and summarising data for progress reports and presentations
- General laboratory management and instrument maintenance duties
- _Please note that this list is not exhaustive_
- **Your Qualifications and Experience***:**Essential**:

- A bachelor’s degree in Biology, Biochemistry, or a related discipline
- Proven track record with at least 3 years’ experience working in an academic or industrial setting
- Experience with stem cells, including their characterisation and differentiation into desired target cell
- Experience with cell-based assays using flow cytometry and magnetic bead separation (MACS or similar)
- Experience with primary immune cell culture, preferably monocytes/macrophages
- Experience in molecular biology techniques such as nucleic acid extraction and purification, PCR and qPCR
- Experience in western blotting, ELISA, immunofluorescence, and immunohistochemistry
- Ability to maintain accurate and up to date records, as proven by a track record of publications as co-author

**Preferable**:

- Experience working with iPSCs and differentiation
- Knowledge of cell engineering techniques
- A working knowledge of inflammation and chronic liver disease
- Experience with cloning and transfection
- Familiarity with the principles of Good Clinical Practice (GCP) and Good Manufacturing Practice (GMP) and writing of standard operating procedures
- ** Selection Process**:

1. Initial meeting with the Hiring Manager and another member of the RTx team
- 2. Presentation & panel interview
- 3. Conversation with the CEO

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