Research Fellow

1 month ago


Edinburgh, United Kingdom The University of Edinburgh Full time

Full-time: 35 hours per week

Fixed Term: until 30 June 2025

We are looking for a postdoctoral researcher to develop novel stem cell gene therapies for childhood neurological diseases. Your main role will be to develop to develop a novel therapy for Sanfilippo disease (MPSIIIA) using gene-corrected iPSC-derived neuronal cells. Experience of working with mouse disease models and iPSCs is essential.

This post is advertised as full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns. 

The Opportunity:

The position offers an ideal opportunity for an enthusiastic, well-motivated postdoctoral researcher, who wants to be part of a programme of research within the laboratory of Professor Brian Bigger. It is ideally suited to a recent PhD graduate. The post holder will build on existing work and expertise in the Bigger lab by helping to develop new treatments for devastating childhood dementias such as Sanfilippo disease. The lab has two gene therapies currently in clinical trial, so this is an opportunity to be at the forefront of translational gene therapy for neurological diseases.

*due to limited budget on the project, offers can be made up to step 3 UE07 grade for the duration of the post. A salary over this threshold may result in a reduced duration of contract.

Your skills and attributes for success: 

  • A PhD (achieved or about to be awarded) in neuroscience, cell biology, biochemistry, gene therapy, pharmaceutical sciences or a related haematological discipline. 
  • Excellent research and methodological skills relevant to the research theme.
  • Experience of working with stem cells
  • Experience of working with viral vectors, in particular lentivirus.
  • Experience of working with animals/personal licence.

£39,347 to £46,974 per annum. Due to limited budget on the project, offers can be made up to step 3 UE07 grade for the duration of the post. A salary over this threshold may result in a reduced duration of contract.



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