Postdoctoral Research Fellow

2 weeks ago

Edinburgh, United Kingdom University of Edinburgh Full time

**Grade UE07 - £39,347 - £46,974 per annum**

**College of Medicine and Veterinary Medicine - MRC - Human Genetics Unit**

**Full time - 35 hours per week**

**Fixed term contract - 24 months
**The Opportunity**:
A postdoctoral researcher is sought for an initial 24-month post in Professor Yanick Crow's group to investigate links between genomic DNA and interferon-mediated innate immune signalling.

The primary viral DNA sensor cGAS is present in the nucleus, begging the question as to how the immunogenicity of self-nuclear DNA is regulated. Related to this observation, in 2020, we described mutations in the replication-dependent histone pre-mRNA processing complex to result in enhanced cGAS-STING mediated interferon signalling through a disturbance of linker histone protein stoichiometry (Nat Genet, 2020, 52, 1364-72). More recently, in unpublished data, we have identified mutations in a chromatin remodeller to also lead to cGAS-dependent interferon induction. Notably, these mutations are associated with significant neurological disease.

**In line with these observations, this new role will focus on the link between nuclear DNA/chromatin and interferon signalling in iPSC-derived neurological cell types **.

The post is available from 1 st June 2024.This post is full-time (35 hours per week),

**Your skills and attributes for success**:

- Expertise in chromatin biology and/or innate immune signalling
- Specific skills relating to the following techniques: mammalian cell/tissue culture, cloning and transfection, gene silencing and editing (CRISPR), transcriptomic profiling, western blotting, iPSC/neuronal cell culture and experimentation, CUT&TAG/CUT&RUN, immunoprecipitation, mass spectrometry
- Excellent knowledge of scientific English for speaking, reading, and writing

**Click to view a copy of the full **job description**

**As a valued member of our team you can expect**:

- A competitive salary of £39,347 - £46,974 per annum
- An exciting, positive, creative, challenging and rewarding place to work.
- To be part of a diverse and vibrant international community
- Comprehensive Staff Benefits, such as a generous holiday entitlement, a defined benefits pension scheme, staff discounts, family-friendly initiatives, and flexible work options. Check out the full list on our **staff benefits page **(opens in a new tab) and use our reward calculator to discover the total value of your pay and benefits

**Championing equality, diversity and inclusion**

The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.

Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our **right to work webpages **(opens new browser tab).

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