Research Assistant/associate

1 month ago

Newcastle upon Tyne, United Kingdom Newcastle University Full time

**Salary**:
**Research Assistant**: £31,396 to £32,982 per annum
**Research Associate**: £33,966 to £44,263 per annum

Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.

**Closing Date**: 06 June 2024

The Role

**Your role**: Our lab has demonstrated that cellular senescence is induced by Chemotherapy. Through the production of a senescence-associated secretory phenotype (SASP), which is pro-senescent, pro-fibrotic and pro-hypertrophic, we hypothesise that senescent cells promote adverse myocardial remodelling. This ultimately impairs cardiac dysfunction. Our goal now is to characterises these senescent cells and find novel way to target them to improve cardiovascular health outcomes for cancer survivors.

**The project**: Improved diagnosis and treatment have significantly increased cancer patient survival. However, cardiotoxicity leading to heart failure is a major complication of many anti-cancer therapies and a growing healthcare problem, cardiovascular disease now being the leading cause of death in cancer survivors. Senescence is a cellular fate defined by cell cycle exit, mitochondrial dysfunction and the expression of the pro-senescent, pro-fibrotic and pro-inflammatory senescence-associated secretory phenotype and is a recognised outcome of chemotherapy. Our data from mouse models in which myocardial senescence has been induced by various stimuli (irradiation, natural ageing or ischaemia reperfusion) suggest that an accumulation of cardiac senescence leads to myocardial dysfunction by promoting myocardial remodelling. In this project, we aim to translate these studies by using human induced pluripotent stem cell-derived cardiomyocytes and primary cells to establish in vitro models of chemotherapy-induced senescence in several human cardiac cell lineages. These models will be utilised to characterise the senescent phenotype in order to identify prognostic biomarkers of cardiac dysfunction, molecular therapeutic targets, and identification of novel cardio-senotherapeutic compounds for mitigation of chemotherapy-induced heart failure.

This post is fixed term for a period 3 years.

Please note that if you are successful to this role, you will require medical clearance before you can commence in the role.

As part of our commitment to career development for research colleagues, the University has developed 3 levels of research role profiles. These profiles set out firstly the generic competences and responsibilities expected of role holders at each level and secondly the general qualifications and experiences needed for entry at a particular level.

Key Accountabilities
Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'
Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
Determine appropriate methodologies for research, with advice and support where required
Begin to write, with appropriate support, proposals for individual research funding or, where funders do not permit this, contribute to the writing of collective bids
Assess research findings for the need/scope for further investigations
Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the Institute.
May contribute to events celebrating the public engagement of science/social sciences/humanities
Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment

The Person

Knowledge, Skills and Experience
Ability to work well as part of a team and rapidly acquire new skills
Likelihood of advanced skills directly related to the research projects
High level of analytical and problem-solving capability
Ability to communicate complex information with clarity and to encourage the commitment of others
Experience of research with clear transferable skills and some experience or awareness of the research environment
Presentations at conferences and/or high-quality publications
Experience in cardiomyocytes cell culture and models of senescence
Documen

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