Research Assistant/research Associate in Structural
2 weeks ago
**Salary**:
**Research Assistant**: £31,396 to £32,982 per annum
**Research Associate**: £33,966 to £36,024 per annum
Newcastle University is a great place to work, with excellent benefits. We have a generous holiday package; plus the opportunity to buy more, great pension schemes and a number of health and wellbeing initiatives to support you.
**Closing Date**: 30 April 2024
The Role
The school of natural and environmental sciences are looking for an enthusiastic and highly motivated Research Assistant or Research Associate to join the laboratory of Professor Paul Race. This position is based within the Molecular Biology and Biotechnology Group, at Newcastle University.
The Diels-Alder reaction is one of the most effective methods for the synthesis of substituted cyclohexenes and is considered the prototypical pericyclic reaction. Despite its unquestionable usefulness, detrimental features include general requirements for harsh reaction conditions (heat, pressure, metal catalysts) and may lead to mixtures of products. These complexities have fuelled recent efforts focused on the discovery and development of protein catalysts for this reaction, which hold promise in offering stereoselective 'green' routes to cyclohexenes at room temperature and pressure. This project will combine protein X-ray crystallography with biophysical and biochemical methods to characterise natural Diels-Alderases and explore their utility in the (bio)synthesis of pharmaceutical lead compounds. You will work in close collaboration with researchers based at the University of Bristol and at our industrial partner AstraZeneca, in realising the potential of Diel-Alder biocatalysts.
The Race lab embraces a diverse, inclusive, and sympathetic research culture. The lab provides an exceptional setting in which to carry out the proposed research project and benefits from multiple national, international and industrial collaborations, which add significant value to our research activity. You will be based in shared laboratory space with other members of the Molecular Biology and Biotechnology Group, ensuring a stimulating and supportive work environment.
You will be encouraged to engage with a plethora of School and Faculty level Early Career Researcher initiatives and will be made aware of access to the University Wellbeing & Support Services. Moreover, Newcastle University provides several training and development courses that you will have the opportunity to undertake.
This post is full time, fixed term for a period of 33.4 months, with a start date of around May 2024.
Key Accountabilities
- Although working under the general guidance of an academic or Principal Investigator, the postholder will contribute ideas, including enhancements to the technical or methodological aspects of their studies, thus providing substantial 'added value'
- Develop and carry out the specified project using appropriate techniques and equipment as outlined in the personal requirements
- Determine appropriate methodologies for research, with advice and support where required
- Assess research findings for the need/scope for further investigations
- Contribute to the writing up of their research for publication and dissemination, either through seminar and conference presentations or through publications
- Present research findings, either at conferences or through publications in reputable outlets appropriate to the discipline
- May be involved in the supervision, with guidance, of final year undergraduate research projects and in providing support to postgraduate research students or Research Assistants
- Will need to work with the support staff and, on occasions, with undergraduate and postgraduate students, and interact intellectually with other academic members of the School
- May contribute to events involving the public engagement of science
- Develop an awareness of University structures, policies and procedures and relevant issues in the higher education, research, social and political environment
The Person
Knowledge, Skills and Experience
- Ability to work well as part of a team and rapidly acquire new skills
- Likelihood of advanced skills directly related to the research projects
- High level of analytical and problem-solving capability
- Ability to communicate complex information with clarity and to encourage the commitment of others
- Experience of research with clear transferable skills and some experience or awareness of the research environment
- Presentations at conferences and/or high-quality publications
- Evidence of previous high-quality work published in this or a relevant/related area
- Prior extensive experience of recombinant protein production in E. coli, including expression and purification strategies
- Experience in the elucidation of protein structures, specifically of Diels-Alderases, using X-ray crystallography, including protein crystallisation, X-ray diffraction data collection and processing, and structure eluci
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