Lead, Biotherapeutic Production

2 weeks ago

Cambridge, United Kingdom AbCellera Full time

**How you might spend your days**:

- Building and leading a high functioning biotherapeutic expression and bioanalytical team to support AbCellera UK's pipeline of therapeutic antibody programs
- Leading the development and integration of a robust suite of analytical assays for antibody and bispecific antibody assessment into the UK site workflow, which might include mass spectrometry, analytical chromatography, capillary electrophoresis, isoelectric focusing, light scattering and related techniques
- Implementing and optimising methodologies to drive high and medium throughput recombinant antibody expression and purification, including molecular biology workflows
- Coaching, mentoring, and developing talent within a growing and dynamic team
- Staying scientifically current, driving innovation, and implementing new technologies and workflows
- Leading the development and implementation of standard operating procedures

**We'd love to hear from you if**:

- You are a builder who is passionate about developing innovative approaches to the discovery and development of biotherapeutics
- You are strongly self-motivated and can identify project needs and implement solutions
- You think critically, are curious and want to explore new technologies to improve the speed and quality of antibody expression processes
- You take pride in investing time to mentor team members to enhance their skills and drive career development and high performance
- You are an outstanding communicator and teammate

**Required qualifications and experience**:

- Demonstrated expertise in detailed analytical characterization of antibodies, bispecific antibodies or other biotherapeutics using analytical chromatography, capillary electrophoresis, isoelectric focusing, light scattering, or related techniques. Experience of mass spectroscopy is a bonus
- Demonstrated expertise in antibody and other protein purification technologies, including affinity, size exclusion and ion exchange chromatographic techniques
- In depth understanding of antibody sequence and structure as well as common modifications, degradation mechanisms, and CQAs
- Experience with antibody stability and developability assessment including both high throughput screening and detailed interrogation of physical and chemical stability risks
- A track record of successful people and team leadership, with a focus on developing talent
- Great interpersonal skills with the ability to work collaboratively as a member of cross-functional and global teams
- Experience working within a CMC organization, or familiarity with regulatory issues related to biologics quality would be highly advantageous
- Demonstrated drug discovery project leadership is desirable
- Excellent documentation, organizational and communication skills
- Impeccable attention to detail

**What we offer**:
A generous compensation package including an equity stake in AbCellera's success. This post is located at our newly refitted labs and offices in one of the beautiful science parks in the Cambridge, UK biotech hub.

**About AbCellera**:
At AbCellera, we find the next generation of therapeutic antibodies. To succeed, we have created innovative solutions at every step - custom antigen preparation and immunizations, microfluidics, high-throughput imaging, genomics, computation, machine learning and laboratory automation - leaving no stone unturned and revolutionizing how scientists can explore natural antibody diversity and the scale at which they can do it. You'll join a diverse and multi-disciplinary team of biologists, biochemists, engineers, bioinformaticians, computer scientists and physicists - all working together to bring better therapies to patients. This is life-changing research and you could be a part of it.

We're a growing company with state-of-the-art discovery tools and the drive to be the best in the industry. This isn't just about having the best technology. We know we need a world-class team of innovators working together to solve the toughest problems. We look for people with drive and energy. Idealists. People we love and people we trust. This may be unconventional, but it is the key to our success. We're looking for someone like you to support and organize our efforts along the way.

**To apply**:

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