Research Assistant

2 weeks ago

Harwell, United Kingdom MRC Harwell Full time

The available post is based within established laboratories involved in the genotyping and quality control of mouse colonies held at the MLC. The group uses a range of molecular biology techniques for genotyping the broad diversity of alleles held at the MLC, including complex colonies that harbour several genetic alterations in combination. The post-holder will implement a range of molecular protocols (preparation of DNA, PCR, qPCR, DNA sequencing analysis and pyrosequencing) in a fast-paced environment with a strong customer focus. Their work in this high-throughput laboratory will involve both manual and automated handling of reagents/samples.

Previous experience of qPCR and working in an ISO9001:2015 environment will be an advantage, but not essential as training can be provided.

**Main duties / key responsibilities**:

- Characterisation of genotypes and quality control of genetically modified materials, employing PCR-based techniques and sequencing. Genotyping of mouse biopsies obtained from a large variety of genetically altered colonies. Validation of the genetic background of mice held at the MLC. Sample management and communication of results internally and to stakeholders.
- Other general duties required are to ensure the smooth running of a Molecular Biology laboratory; e.g., ordering reagents - such tasks will be shared with the rest of the team.

**Working relationships**:

- The post-holder will work as part of a team with the other Genotyping team members, processing samples/tasks as directed by the Head of Genotyping.
- The post-holder will work with a range of technical support staff, including highly trained post-doctoral technologists, to produce molecular biology work for the Genotyping service of the MLC.

**Additional information**:
Some flexible work patterns and paid weekend work may be required at the discretion of the supervisor.

Interviews are expected to be held on 27th April and the morning of 28th April.

**Equality & Diversity**:
The MRC values the diverse skills and experience of its employees and is committed to achieving equality of treatment for all. Our objectives are that all individuals shall have equal opportunities for employment and advancement on the basis of their skills, aptitudes and abilities. The MRC is committed to the engagement and retention of the best possible talent and to creating an environment that encourages excellence in scientific research through good equality and diversity leadership and management.

**Corporate/Local Responsibilities & Requirements**:
The post-holder must at all times carry out their responsibilities with due regard to the MRC’s:

- Code of Conduct
- Equality and Diversity policy
- Health and Safety policy
- Data Protection and Security policy

Job descriptions should be reviewed on a regular basis and at the annual appraisal. Any changes should be made and agreed between the post-holder and their manager.

The above lists are not exhaustive and the post-holder is required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, cooperatively and flexibly in line with the requirements of the post and the MRC.
- Person Specification**Education/Qualifications/Training Required**:

- Essential:_
- Desirable:_

MSc in Biological Sciences with several years’ laboratory-based molecular biology training. Understanding of genome engineering techniques (gene targeting, CRISPR-based tools).

**Previous Work Experience Required**:

- Essential:_

Experience of working in a laboratory.
- Desirable:_

Previous work with genetically modified materials.

Previous experience in PCR, qPCR, ddPCR. Evidence of quality and customer-focused work.

**Knowledge and Experience**:

- Essential:_

Experience in basic techniques of molecular biology; e.g., PCR, cloning, DNA sequence analysis.

Computer literacy is essential for the recording and communication of results.

An understanding of genetic modification in laboratory animals.
- Desirable:_

Working and adhering to standard operating procedures and experience of process analysis and refinement.

**Personal skills/Behaviours/Qualities**:

- Essential:_

Organised and hard-working with precision and a strong eye for detail, and able to work well as part of a team.
- Desirable:_

Able to communicate clearly and concisely with a variety of scientists at all levels (from principal investigator to research assistants and animal technicians).
- Further InformationThe post-holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment.

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