Cell-intrinsic and Environmental Sources of

2 weeks ago


City of York, United Kingdom Springer Nature Full time

**Cell-intrinsic and environmental sources of mutations in cancer**:

- Employer- NYU Langone Health- Location- New York City, New York (US)- Salary- $70,000 to $75,000- Closing date- 23 Apr 2024- Discipline
Health Science
Job Type
Postdoctoral
Employment - Hours
Full time
Duration
Permanent
Qualification
PhD
Sector
Hospital- You need to sign in or create an account to a job.

**Cell-intrinsic and environmental sources of mutations in cancer**

is seeking a **Postdoctoral Fellow** to join a multidisciplinary team investigating the cell
- intrinsic and environmental causes of somatic mutations in human tissues, as well as their
impact on cancer development and evolution. Building upon our foundational work (Cell,
2019; Nature, 2023; Nature Genetics, 2023), our team leverages mutational signatures,
distinct genomic imprints left by individual mutagens on human genomes, to identify and
characterize individual mutagenic sources. Through this approach, we aim to discover
processes that cause and fuel cancer evolution, as well as aid in the development of
innovative preventative and therapeutic strategies to prevent and treat it.

biomarkers and/or functional impact of the suspected or poorly defined cell-intrinsic and/or
environmental mutagens in cancer. Working side-by-side with bioinformaticians, you will
benefit from learning computational aspects of the sequencing analyses, engaging in
academic and industry collaborations. Mentorship will be provided by Dr. Petljak in
translating applicable findings into patents and start-up opportunities as applicable. You will
be located with the Petljak lab in the new, state-of-the-art CURE facility at 345 Park Avenue
South in the center of Manhattan.

**Required Education and Experience**
PhD, MD/PhD, or MD.

Preference is given to applicants with strong expertise in both cell and molecular biology in
cancer cells, including but not limited to metabolism, genomic instability, DNA damage,
repair and replication, stem cells, and other cellular states and processes associated with
cancer (e.g., stress, senescence, differentiation, cell cycle, and cell death, inflammatory
signaling).

Computational experience not required.


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