Post Doctoral Training Fellow: Cytoskeleton and
3 weeks ago
**Key Information**:
**Duration of Contract**: Fixed Term for 3 years in the first instance
**Hours per week**: 35 hours per week (Full Time)
**Closing Date**: Tuesday 2nd April 2024
**Interviews**: w/c 15th April 2024
**Job Details**:
Under the leadership of Professor Victoria Sanz-Moreno, we are seeking a creative and motivated Postdoctoral Training Fellow to study tumour invasive patterns, and tumour microenvironmental characteristics associated with invasive and metastatic behaviour.
- The proposed project aims to experimentally characterise how invasive cancer cells interact with the Extracellular Matrix and components of the TME (endothelial cells, immune cells, fibroblasts, etc) Studies will be conducted in the primary tumour and in the metastatic setting.
The project will entail the use on molecular pathology features associated with information we have gathered on cytoskeletal, nuclear, mitochondrial (Rodriguez Hernandez Nat Comm 2020; Jung Nature Cell Biology 2023; Crosas-Molist Nature Communications 2023) and immunosuppressive features (Samain Science Advances 2023, Orgaz Cancer Cell 2020, Georgouli Cell 2019) of highly invasive and metastatic cancer cells.
For general information on Post Doc's at The ICR can be found here.
**Key Requirements**
The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 10 years
**Cytoskeleton and Cancer Metastasis Group**
Rho GTPases are molecular switches that control the cytoskeleton. The spreading of cancer cells from one part of the body to another, called metastasis, is one of the main causes of cancer death.
To metastasise, tumour cells must move through tissues, cross tissue boundaries and survive at secondary sites, which requires cell motility, remodelling of cell-cell contacts, interactions with the extracellular matrix and outgrowth at the secondary tissue.
Rho GTPases control actomyosin contractility, adhesive forces, matrix degradation and pro-survival signalling - all necessary for cells to migrate, disseminate and survive efficiently.
In our lab we are studying how Rho GTPase signalling and cytoskeletal remodelling can control all these processes that are crucial for metastatic cells to succeed at growing in a distant tissue, with a focus on these processes in the context of breast cancer. We are particularly interested in understanding how cancer cells sense extracellular signals via their cytoskeleton and integrate the responses altering gene transcription to promote metastasis.
The team is working on identifying molecular cues that will aid in tumour metastatic dissemination via the crosstalk between the cytoskeleton and the nucleus. Moreover, whether metastatic cells develop an (epigenetic) memory is a matter of active investigation in the lab. We have a particular focus on Rho-kinase (ROCK) and Myosin II, as we believe this axis is crucial for the regulation of many processes in metastatic cancer cells.
How cancer cells interact with the tumour microenvironment is crucial for tumour progression and dissemination. The team aims to understand how the cytoskeleton in cancer cells affects cancer cell-normal cell communication.
Using co-cultures and 3-Dimensional matrix imaging systems, the team analyses communication of cancer cells with endothelial cells, fibroblasts and/or immune cells. These approaches allow manipulation of the cytoskeleton of cancer cells to analyse host tissue responses, both within the matrix and within the non-cancerous cells.
We also aim to understand if this process will be aided by signals sensed by the cytoskeleton of cancer cells and transmitted to transcription factors and/or chromatin. We think this is very important as cancer cells are addicted to transcriptional rewiring.
The lab is highly multidisciplinary, as we use a combination of “OMICs”, state of the art microscopy, molecular and cellular biology, animal models and patient material. The ultimate goal is to define if manipulating the cytoskeleton of cancer cells will lead to improved efficacy of therapeutic approaches in patients with metastatic disease, with a special focus on breast cancer metastasis.
**About The Institute of Cancer Research**:
**Why work for us?**
As a member of staff, you'll have exclusive access to a range of staff benefits.
The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be found here_._
-
Post-Doctoral Research Fellow
4 weeks ago
London, Greater London, United Kingdom University Of The Arts London Full timeThe opportunityThis is an exciting opportunity to join the Abundance project as a Post-Doctoral Research Fellow. The Abundance Project: Enhancing Cultural and Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health is an AHRC funded project led by University of the Arts London and co-led by Kingston...
-
Usawa Post-doctoral Research Fellow
3 weeks ago
London, United Kingdom SOAS University of London Full time**Job title: Usawa Post-Doctoral Research Fellow** **Department: Development Studies** **Contract Type: Fixed term - 1 year** **Salary**:Grade 7 - £40,238.82 - £47,060.82 per annum inc.** **Location: Bloomsbury, London** **Hours: 35 hours per week** SOAS University of London is the leading Higher Education institution in Europe specialising in the...
-
Post Cct Fellow in Paediatric Cardiology in
2 months ago
London, United Kingdom Guy's and St Thomas' NHS Foundation Trust Full timeSenior Clinical Fellow in Paediatric Cardiology Nodal Point 4 / 5 (dependent on clinical experience) Fixed term 12 months This is fixed term post that will provide the postholder an opportunity of exposure to a wide range of paediatric cardiology. There is a possibility that the post could be extended beyond this, depending upon staffing levels and the...
-
London, United Kingdom LSE Jobs Full timeLSE is committed to building a diverse, equitable and truly inclusive university_ **Centre for Philosophy of Natural and Social Science** **Post-Doctoral Research Officer** **Salary from £38,313 pa to £46,148 pa inclusive with potential to progress to £49,614 pa inclusive of London allowance** **This is a fixed-term appointment for 2 years** *** The...
-
Clinical Fellow Post in Anaesthesia
4 weeks ago
London, United Kingdom Homerton Healthcare NHS Foundation Trust Full timeWe are currently advertising two Clinical Fellow posts one with a November 2023 start date and the other with a February 2024 start date. The clinical fellow will be required to take responsibility with his/her colleagues in the provision of a full anaesthetic service to the Trust. The clinical fellow will be responsible to a nominated consultant and the...
-
Clinical Fellow Paediatrics
2 weeks ago
London, United Kingdom Lewisham and Greenwich NHS Trust Full timeTrust Doctor Clinical Fellow (ST1/2) in Paediatric Emergency Medicine Trust Doctor Clinical Fellow (ST1/2 Level) in Paediatric Emergency Medicine. Applications are invited for a full time Clinical Fellow Paediatrician based in the Paediatric Emergency Department at University Hospital Lewisham. There are three vacancies; one of which is for 6 months in the...
-
Clinical Fellow Post in Anaesthesia
4 weeks ago
London, United Kingdom Homerton Healthcare NHS Foundation Trust Full timeThe clinical fellow will be required to take responsibility with his/her colleagues in the provision of a full anaesthetic service to the Trust. The clinical fellow will be responsible to a nominated consultant and the Clinical Director of the department and will be expected to work with consultants to maintain standards, education and develop skills. The...
-
Clinical Fellow Post in Anaesthesia
2 weeks ago
London, United Kingdom Homerton Healthcare NHS Foundation Trust Full timeThe clinical fellow will be required to take responsibility with his/her colleagues in the provision of a full anaesthetic service to the Trust. The clinical fellow will be responsible to a nominated consultant and the Clinical Director of the department and will be expected to work with consultants to maintain standards, education and develop skills. The...
-
London, Greater London, United Kingdom Chelsea and Westminster Hospital NHS Foundation Trust Full timeThe Chelsea & Westminster Hospital is looking to appoint a joint Respiratory and Postgraduate Education Fellow for This post is an exciting opportunity for a junior doctor to formally develop their medical education experience whilst developing knowledge and skill within respiratory medicine.The successful applicant should aim to use the year to build on...
-
Training Recovery Simulation Fellow
2 months ago
London, United Kingdom University College London Hospitals NHS Foundation Trust Full timeApplications are invited for the position of Training Recovery Simulation Fellow at UCLH An exciting opportunity has arisen for a Simulation Fellow to work on simulation-based projects designed to support training recovery across our HEE sponsored training programmes. So if you are passionate about improving and delivering education for doctors in...
-
London, United Kingdom Guy's and St Thomas' NHS Foundation Trust Full timeJob summary The post is based in the children's emergency department, where the post-holder is responsible for the care of all patients, under supervision of a consultant. The senior clinical fellow would be expected to direct the management of ill and injured children, participate in the resuscitation and stabilization of severely ill children, and...
-
London, Greater London, United Kingdom Guy's and St Thomas' NHS Foundation Trust Full timeJob summary The post is based in the children's emergency department, where the post-holder is responsible for the care of all patients, under supervision of a consultant. The senior clinical fellow would be expected to direct the management of ill and injured children, participate in the resuscitation and stabilization of severely ill children, and...
-
London, United Kingdom Guy's and St Thomas' NHS Foundation Trust Full timeJob summary The post is based in the children's emergency department, where the post-holder is responsible for the care of all patients, under supervision of a consultant. The senior clinical fellow would be expected to direct the management of ill and injured children, participate in the resuscitation and stabilization of severely ill children, and...
-
Quality Improvement and Innovation Fellow
2 months ago
London, United Kingdom Health Education England Full timeAn opportunity exists for Clinical Fellows to work within NHS England’s Enhancing Junior Doctors’ Working Lives programme focusing on quality improvement and innovation within Supported Return to Training (SuppoRTT). The post holder will be supported by the Associate Dean for SuppoRTT and Local Office lead, and work closely with SuppoRTT fellows and...
-
Training Recovery Simulation Fellow
4 days ago
London, Greater London, United Kingdom University College London Hospitals NHS Foundation Trust Full timeApplications are invited for the position of Training Recovery Simulation Fellow at UCLHAn exciting opportunity has arisen for a Simulation Fellow to work on simulation-based projects designed to support training recovery across our HEE sponsored training programmes.So if you are passionate about improving and delivering education for doctors in training,...
-
2x Post-doctoral Research Fellow
3 weeks ago
London, United Kingdom University College London Full time**Ref Number** B04-04826 **Professional Expertise** Research and Research Support **Department** UCL BEAMS (B04) **Location** London **Working Pattern** Full time **Salary** See advert text **Contract Type** Fixed-term **Working Type** Hybrid (20% - 80% on site) **Available For Secondment** No **Closing Date** 11-Apr-2024 **About...
-
Senior Clinical Fellow in Emergency Medicine
2 weeks ago
London, United Kingdom Chelsea and Westminster Hospital NHS Foundation Trust Full timeThis post is for a Senior Clinical Fellow who will be based at West Middlesex Emergency Department (0.6 WTE) and are expected to provide clinical cover for the department which will be negotiated with the Rota coordinator. The remaining time will be spent organising education for nurses, doctors and medical students. You will have the opportunity to arrange...
-
Senior Clinical Fellow
4 days ago
London, United Kingdom Chelsea and Westminster Hospital NHS Foundation Trust Full timeEducation & Simulation Senior Clinical Fellow / Education in Emergency Medicine There is excellent opportunity for an Emergency Medicine doctor to advance their career as a Education & Simulation Senior Clinical Fellow in Emergency Fellow (ST4+) with obtaining a postgraduate qualification. Post-holders, who will be based at West Middlesex Emergency...
-
Senior Clinical Fellow
4 weeks ago
London, United Kingdom Barnet and Chase Farm Hospitals Full timeOur trust has around 10,000 staff serving 1.6 million patients. It comprises Barnet Hospital, Chase Farm Hospital, the Royal Free Hospital and more than 30 services in the community. This larger scale organisation provides an unprecedented opportunity for us to continue our pioneering work, particularly in finding ways to deliver even better care to our...
-
Post-Doctoral Associate- Childhood Studies
4 weeks ago
London, United Kingdom Rutgers University Full timePosting Summary The Department of Childhood Studies at Rutgers University—Camden invites applications for a one-year postdoctoral fellowship, renewable for a second year, to commence September 1, 2024. The position will be funded by a Higher Learning grant awarded by the Andrew W. Mellon Foundation as part of the “Rethinking Race and Justice...
