Technical Specialist

4 weeks ago

Cambridge, United Kingdom Wellcome Sanger Institute Full time

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity's greatest challenges.

**About the Role**:
We have an exciting opportunity for a Technical Specialist to join the Lehner group for a 3 year fixed term contract to work on an Open Targets Project.

You will be responsible for:

- Use your previous experience and technical expertise to contribute to the generation of deep mutagenesis libraries and other molecular biology techniques.
- Help write, review and optimise SOPs and associated risk assessments
- Provide guidance and support to less experienced members of the team
- Ensure health and safety standards across the team
- Plan and execute day-to-day work for the maintenance and transfection of human cell cultures, RNA extraction and cDNA library generation

**About Us**:
The Lehner group is newly established at the Wellcome Sanger Institute. The lab is focused on combining massively parallel genetic perturbation experiments with modelling and machine learning to understand, predict and engineer how changes in DNA sequence alter the activities, interactions and regulation of proteins and RNAs. The goal is both to generate reference atlases and predictive models of variant effects to guide clinical genetics and datasets of sufficient scale and diversity to directly tackle the fundamental sequence-to-activity encoding problems of molecular biology using artificial intelligence and modelling. The long-term goal is to make molecular biology and genetics predictive and programmable. Individual projects are focused on fundamental questions in biophysics and genetics or on important protein and gene families or diseases. Example include understanding, predicting and engineering allostery, receptors and membrane proteins, protein binding affinity and specificity, small molecule and drug binding, cancer genes, splicing and post-transcriptional regulation, transcription factors, and intrinsically disordered proteins. The resulting data and models will support clinicians in diagnosing diseases and understanding disease mechanisms. It will also support scientists in designing and producing new proteins and small molecules for disease treatment and bioengineering.

**Essential Skills**:

- MSc or equivalent experience in molecular biology, genomics, biophysics, biotechnology or a related discipline
- Significant postgraduate experience
- Ability to test, implement, and troubleshoot new techniques and protocols
- Excellent communication skills
- Proven ability to work effectively within a team
- Ability to be independent and organised
- Good attention to detail and systematic record keeping for sample and experimental tracking
- An understanding and experience with molecular biology and molecular genetics techniques
- Previous work experience in a molecular biology, biophysics or genomics laboratory
- Ability to follow instructions/protocols accurately & efficiently
- Strict adherence to SOPs and attention to detail when performing routine tasks
- Excellent communication skills
- Proven ability to work effectively within a team
- Ability to be independent and organised
- Good attention to detail and systematic record keeping for sample and experimental tracking

**Other information**:
**Salary per annum: £39,343-£46,741**

**Closing Date: 21st May 2023**

**Working at Wellcome Sanger**:
Our flexible-hybrid working environment is designed to support a healthy work-life balance. This means you can work flexibly with a combination of working from home, and working from our Campus to allow you to focus on being productive and part of the team while enjoying the benefits of working flexibly.

We aim to attract, recruit, retain and develop talent from the widest possible talent pool, thereby gaining insight and access to different markets to generate a greater impact on the world. We have a supportive culture with the following staff networks, LGBTQ+, Parents and Carers and Race Equity to bring people together to share experiences, offer specific support and development opportunities and raise awareness. The networks are also a place for allies to provide support to others.

We want our people to be whoever they want to be because we believe people who bring their best selves to work, do their best work. That's why we're committed to creating a truly inclusive culture at Sanger Institute. We will consider all individuals without discrimination and are committed to creating an inclusive environment for all employees, where everyone can thrive.

**Our Benefits**:
We are proud to deliver an awarding campus-wide employee wellbeing strategy and programme. The importance of good health and adopting a healthier lifestyle and the commitment to reduce work-related stress is strongly acknowledged and recognised at Sanger Institute.

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