Post-doctoral Research Fellow

4 weeks ago

Edinburgh, United Kingdom University of Edinburgh Full time

**Job Advert Template**

**UE07 £37,099 - £44,263**

**Human Genetics Unit within the IGC**

**Full-Time 35 hours per week**

**Fixed-Term for 2 years**

A postdoctoral researcher is sought for a two-year post in Professor Yanick Crow's group to investigate the interrelationships between Toll-like receptor (TLR) and cytosolic nucleic acid innate immune signalling.

**The Opportunity**:
As exemplified by the type I interferonopathies, Mendelian diseases associated with chronically enhanced type I interferon signalling, while essential in protection against infection, inappropriate activation of interferon signalling can be pathogenic. To date, characterisation of the type I interferonopathies has emphasised cytosolic nucleic acid sensing pathways in disease pathogenesis. However, we have recently implicated Toll-like receptor (TLR) endosomal signalling as central to the pathogenesis of three novel type I interferonopathies. Notably, our unpublished data indicate an unexpected degree of ‘cross-talk’ between the TLR and cytosolic nucleic acid sensing pathways. This new post is designed to explore these observations in detail.

**Your skills and attributes for success**:

- Extensive laboratory experience in cell and molecular biology experimentation
- Specific skills relating to the following techniques: mammalian cell/tissue culture, cloning and transfection, gene silencing and editing (CRISPR), microscopy, transcriptomic profiling, western blotting, immunoprecipitation, mass spectrometry
- Excellent knowledge of scientific English for speaking, reading, and writing

**Click to view a copy of the full **job description **here.

**As a valued member of our team you can expect**:
An exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent and reward success. You will benefit from a competitive reward package and a wide range of staff benefits, which includes a generous holiday entitlement, a defined benefits pension scheme **, **staff discounts, family-friendly initiatives, flexible working and much more. Click to access our **staff benefits page **(opens new browser tab) for further information and use our reward calculator to find out the total value of pay and benefits provided.

The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.

Prior to any employment commencing with the University you will be required to evidence your right to work in the UK. Further information is available on our **right to work webpages **(opens new browser tab)

Interviews will be held **in due course.

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