Post-doctoral Research Fellow

2 months ago

Edinburgh, United Kingdom University of Edinburgh Full time

**UE07 £36,333 - £43,155**

**College of Medicine & Veterinary **Medicine, Institute of Genetics and Cancer within the Human Genetics Unit**

**Full-Time 35 hours**

**Fixed-Term 9 months**

We are looking for a post-doctoral researcher is sought for a one-year post in Professor Yanick Crow's group to investigate the link between nuclear DNA and interferon-mediated innate immune signalling.

**The Opportunity**:
In a surprising finding, it has been shown that the primary viral DNA sensor cGAS is present in the nucleus, begging the question as to how the immunogenicity of self-nuclear DNA is regulated. Related to this observation, in 2020, we described mutations in the replication-dependent histone pre-mRNA processing complex to result in enhanced cGAS-STING mediated interferon signalling through a disturbance of linker histone protein stoichiometry and an altered distribution of nuclear cGAS (Uggenti et al., Nat Genet, 2020, 52, 1364-72). More recently, in unpublished data, we have identified mutations in a chromatin remodeller to also lead to cGAS-dependent interferon induction.

**Your skills and attributes for success**:

- Expertise in mass spectrometry and co-immunoprecipitation
- Specific skills relating to the following techniques: mass spectrometry, co-immunoprecipitation, mammalian cell/tissue culture, cloning and transfection, gene silencing and editing (CRISPR), transcriptomic profiling, western blotting, ChIP-seq, ATAC-seq

**Click to view a copy of the full **here.

**As a valued member of our team you can expect**:
An exciting, positive, creative, challenging and rewarding place to work. We give you support, nurture your talent and reward success. You will benefit from a competitive reward package and a wide range of staff benefits, which includes a generous holiday entitlement, a defined benefits **pension scheme **, **staff discounts, **family friendly initiatives **, flexible working and much more. Access our **staff benefits page **for further information and use our **reward calculator **to find out the total value of pay and benefits provided.

The University of Edinburgh holds a Silver Athena SWAN award in recognition of our commitment to advance gender equality in higher education. We are members of the Race Equality Charter and we are also Stonewall Scotland Diversity Champions, actively promoting LGBT equality.

If invited for interview you will be required to evidence your right to work in the UK. Further information is available on our **right to work **webpages **(opens new browser tab).

  • Post-doctoral Research Fellow

    2 weeks ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE07: £37,099 - £44,263 per annum** **College of Medicine and Veterinary Medicine / Edinburgh Medical School / Deanery of Biomedical Sciences / Centre for Discovery Brain Sciences** **Full Time Contract: 35 hours per week** **Fixed Term Contract: 24 months** **The Opportunity**: We are seeking to recruit a highly motivated, curious and driven...

  • Post-doctoral Fellow

    2 months ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **Grade UE07: £37,099 - £44,263** **Edinburgh Cancer Research / Institute of Genetics and Cancer** **Full-time: 35 hours per week** **Fixed-term: 3 years** We are looking for a Post-Doctoral Fellow to join the team led by Prof Margaret Frame and Prof Asier Unciti-Broceta at the Edinburgh Cancer Research. The post holder will conduct original research...

  • Post-Doctoral Research Fellow

    2 weeks ago

    Edinburgh, Edinburgh, United Kingdom The University of Edinburgh Full time

    Full-time: 35 hours per weekFixed-term: 2.5 yearsThe OpportunityThis is an exciting opportunity to work in a dynamic translational research lab that is focussed on research in Type 1 diabetes and in particular optimising islet transplantation outcomes in diabetic rodent models. This position is to support a research programme funded by the Steve Morgan...

  • Post-Doctoral Research Fellow

    2 months ago

    Edinburgh, Edinburgh, United Kingdom The University of Edinburgh Full time

    Full-time: 35 hours per weekFixed-term: 2.5 yearsThe OpportunityThis is an exciting opportunity to work in a dynamic translational research lab that is focussed on research in Type 1 diabetes and in particular optimising islet transplantation outcomes in diabetic rodent models. This position is to support a research programme funded by the Steve Morgan...

  • Post-Doctoral Research Fellow

    2 months ago

    Edinburgh, United Kingdom The Institute Full time

    Full-time: 35 hours per week Fixed-term: 2.5 years The Opportunity This is an exciting opportunity to work in a dynamic translational research lab that is focussed on research in Type 1 diabetes and in particular optimising islet transplantation outcomes in diabetic rodent models. This position is to support a research programme funded by the Steve...

  • Post-Doctoral Research Fellow

    2 weeks ago

    Edinburgh, United Kingdom The University of Edinburgh Full time

    Full-time: 35 hours per week Fixed-term: 2.5 years The Opportunity This is an exciting opportunity to work in a dynamic translational research lab that is focussed on research in Type 1 diabetes and in particular optimising islet transplantation outcomes in diabetic rodent models. This position is to support a research programme funded by the Steve Morgan...

  • Post-Doctoral Research Fellow

    2 months ago

    Edinburgh, United Kingdom The University of Edinburgh Full time

    Full-time: 35 hours per week Fixed-term: 2.5 years The Opportunity This is an exciting opportunity to work in a dynamic translational research lab that is focussed on research in Type 1 diabetes and in particular optimising islet transplantation outcomes in diabetic rodent models. This position is to support a research programme funded by the Steve Morgan...

  • Post-doctoral Research Fellow

    2 months ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE07: £35,333.00 - £42,155.00 Per Annum.** **CMVM / Usher Institute / CMI.** **Fixed Term Contract - Available from 1 June 2023 to 31 May 2025; Full Time - 35 Hours Per Week.** The Centre for Medical Informatics at the Usher Institute within The University of Edinburgh is looking for a Postdoctoral Research Fellow to work with an interdisciplinary team...

  • Post-doctoral Research Fellow

    2 months ago

    Edinburgh, Edinburgh, United Kingdom The University of Edinburgh Full time

    Contract type: Full-time (35 hours per week)Fixed-term: 12 monthsThe opportunity:We are looking for an enthusiastic and self-motivated post-doctoral researcher with skills in molecular and/or computational biology to characterise the pathogenesis of key livestock apicomplexan parasites. This full-time (35 hours per week) position offers a unique opportunity...

  • Clinical Research Fellow

    2 months ago

    Edinburgh, United Kingdom Canon Medical Research Europe Full time

    **About us**: At Canon Medical Research Europe, helping care teams to get the best outcome for their patients is at the heart of everything we do. We strive to create technology that makes a meaningful difference to people’s lives, helping doctors restore their patients’ health and well-being. Our R&D centre of excellence in Edinburgh are seeking an...

  • Post Doctoral Research Fellow

    2 days ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE07 £36,333- £43,155 Per Annum** **College of Medicine & Veterinary Medicine / Deanery of Clinical Sciences / Centre for Cardiovascular Sciences** **Fixed term (22 month contract)** **Full time (35 hours per week)** We are looking for a highly motivated Postdoctoral Research Fellow for project funded by MRC exploring how obesity leads to B cell...

  • Post Doctoral Research Fellow

    3 days ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE07 £36,333 - £43,155 Per Annum** **College of Medicine & Veterinary Medicine / Deanery of Clinical Sciences / Centre for Cardiovascular Sciences** **Fixed term (31 month contract)** **Full Time (35 hours per week)** We are looking for a motivated post-doctoral researcher to contribute to and lead interdisciplinary studies on cardiovascular immunology...

  • Clinical Research Fellow

    3 days ago

    Edinburgh, United Kingdom Canon Medical Research Europe Full time

    **About us**: At Canon Medical Research Europe, helping care teams to get the best outcome for their patients is at the heart of everything we do. We strive to create technology that makes a meaningful difference to people’s lives, helping doctors restore their patients’ health and well-being. Our R&D centre of excellence in Edinburgh are seeking an...

  • Research Fellow

    2 weeks ago

    Edinburgh, Edinburgh, United Kingdom The University of Edinburgh Full time

    Full time: 35 hours per weekFixed term: 24 monthsWe are looking for a postdoctoral Research Fellow with experience in public health and commercial determinants of health, including but not limited to tobacco, alcohol, or ultra-processed food industries, to join a major UKRI-funded collaborative project based in the Global Health Policy Unit.The...

  • Research Fellow

    2 months ago

    Edinburgh, Edinburgh, United Kingdom The University of Edinburgh Full time

    Full time: 35 hours per weekFixed term: 24 monthsWe are looking for a postdoctoral Research Fellow with experience in public health and commercial determinants of health, including but not limited to tobacco, alcohol, or ultra-processed food industries, to join a major UKRI-funded collaborative project based in the Global Health Policy Unit.The...

  • Post-doctoral Research Fellow in Injury

    7 days ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **Grade UE07: £39,347-£46,974 per annum** **CAHSS/Moray House School of Education & Sport/Institute of Sport, Physical Education & Health Sciences (SPEHS)** **Full-time: 35 hours per week** **Fixed-term: 36 months **The Opportunity** This is a joint-funded Post-Doctoral post with funding in place for three years. It is an exciting opportunity to work...

  • Post-doctoral Fellow

    4 weeks ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE07 £35,333 - £42,155 per annum** **MVM/CCBS** **Full time; 35hrs per week** **Fixed Term; 2 years** We are looking for an appointee who will integrate into a multidisciplinary research group (Dr Selvaraj/Prof Chandran) within the UK Dementia research institute to contribute and expand our knowledge on pathophysiology of motor neuron disease (MND)...

  • Post-doctoral Fellow

    4 weeks ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE07 £35,333 - £42,155 per annum** **MVM/CCBS** **Full time; 35hrs per week** **Fixed term; 2 years** We are looking for an appointee who will integrate into a multidisciplinary research group (Dr Selvaraj/Prof Chandran) within the UK Dementia research institute to contribute and expand our knowledge on pathophysiology of motor neuron disease (MND)...

  • Post-doctoral Research Fellow

    4 days ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE07 £36,333 - £43,155 Per Annum** **College of Medicine & Veterinary Medicine / Deanery of Clinical Sciences / Centre for Cardiovascular Sciences** **Fixed term (until 30th April 2027)** **Full time (35 hours per week)** We are looking for a post-doctoral scientist to work on a cross European gene therapy programme. **The Opportunity**: **Your...

  • Post Doctoral Researcher

    2 weeks ago

    Edinburgh, United Kingdom University of Edinburgh Full time

    **UE07- £37,099- £44,263** **CAHSS/ School of Economics** **Full Time, 35 hours per week** **Fixed Term Contract (36 months)** **The Opportunity**: The School of Economics is growing and is seeking to appoint a Post-Doctoral Researcher to undertake high quality research, knowledge exchange, and capacity building activities supporting the UKRI/ERC grant...