Research Officer
5 days ago
Applications are invited for the above full-time Post-doctoral research post working in the laboratory of UKRI Future Leader Fellow Dr Chris Staples, within the North West Cancer Research Institute, School of Medical and Health Sciences. The project will involve in-depth analysis of post-replicative repair mechanisms in cancer cell lines, employing many standard molecular and cell biology techniques in addition to generation of KO cell lines and DNA fibre assays. The successful applicant will also conduct a genome-wide CRISPR-Cas9-based chemogenetic screen to identify novel cancer cell vulnerabilities.
This role will be located on campus at Bangor.
Committed To Equal Opportunities
Overview
North-West Cancer Research Institute, School of Medical Sciences:
The successful applicant will work within a vibrant and well-funded laboratory within the NWCRI. Research in the NWCRI focuses on cancer cell biology and genetics, from molecular characterisation to biomarker identification and drug development. The Staples laboratory focuses on the replication stress response (Bennett et al., 2020 Sci Adv), and on the identification of novel cancer genetic vulnerabilities via pooled genome-wide CRISPR screening.
The Project
Purpose of the Job
The post holder will be responsible for helping plan, conduct, analyse and publish a series of laboratory experiments with the aim of fully elucidating the novel mechanism that is being investigated. The successful applicant will gain important experience by assisting with manuscript writing and figure preparation and will have the opportunity to present their work at national and international conferences.
Main
**Responsibilities**:
- Conducting publication-quality, reproducible laboratory-based experiments involving several standard and advanced techniques (Western blotting, immunofluorescence, DNA fibre assays, flow cytometry, generation of KO cell models via CRISPR, genome-wide CRISPR screening).
- Data analysis and interpretation (mainly Excel, ImageJ, Prism).
- Administration of the research project (ordering, time management).
- Actively participate in group meetings and departmental meetings.
- Assist with manuscript preparation.
- Present findings at meetings when appropriate.
Other
**Responsibilities**:
- The post holder will be expected to participate in performance review and developmental activities.
- The post holder will be expected to comply with the University’s equality policies and statements, Dignity at Work and Study Policy and the University’s Welsh Language Scheme.
- The post holder has a general and legal duty of care in relation to health, safety and wellbeing and must take all reasonable steps to ensure a safe and healthy working environment for him/her self and for other members of staff, students and visitors affected by his/her actions or inactions. The post holder is also required to comply with all applicable health and safety policies, procedures and risk assessments.
- The post holder must comply with relevant legal and financial policies and procedures and be aware of their responsibilities in terms of the legal requirements of their posts.
Person Specification
Qualifications/Training
Essential:
Experience/Knowledge
Essential:
- The ability to undertake appropriate quantitative analysis.
- Excellent general knowledge of cell and molecular biology.
- Previous experience of any techniques listed in the description above.
- Proven track record of publications in quality journals.
Desirable:
- Proven track record of conference presentations.
Skills/Abilities
Essential:
- Demonstrate good verbal and written skills.
- Demonstrate good analytical skills, ability to analyse numerical data and present results appropriately.
- Demonstrate the ability to prioritise workload and work to deadlines.
Desirable:
- Demonstrate proven project management skills.
- Demonstrate good computer skills, including MS Office, Powerpoint, Excel.
- Demonstrate ability to work as part of a team.
- Any other skills / abilities relevant to the duties and responsibilities.
- Demonstrate interpersonal skills.
Other
Essential:
General
We are a member of Advance HE's Athena SWAN Gender Equality charter and hold a Bronze award in recognition of our commitment to and progress towards gender equality within the University's policies, practices, and culture. We are proud to be a Disability Confident employer.
All members of staff have a duty to ensure their actions are in line with the overall environmental aims of the University and minimise their environmental impact.
Disclosure & Barring Service
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