Senior/Laboratory Research Scientist
2 weeks ago
Research Scientist / or Senior Scientist I - Target Discovery and Validation
Chesterford research Park - Cambridge UK
Permanent
We're ambitious about our science and its potential to deliver meaningful therapeutics to the patients that need them most. We believe in a culture of diversity, equality and investing in people to ensure our talented and passionate team members can fulfil their full potential.
We are based in spacious and modern laboratory and office facilities at Chesterford Research Park near Cambridge, UK - right in the very heart of the UK life science sector. Our facilities are equipped with state-of-the-art instruments to enable our dedicated researchers to deliver incredible science.
This is an outstanding new opportunity for a proactive and energetic Research Scientist/Senior Scientist to join an innovative biotech company and work closely with experienced scientists. We are looking for a highly collaborative cellular biologist with a passion for science who would like to join a committed, dynamic team and share our vision to bring new therapies to patients in need.
The successful candidate will work closely with project leads within the Target Discovery team to develop translational human in vitro models of fibrotic disease and apply these in a CRISPR knockout screen to facilitate the identification of novel targets.
You will undertake development of complex 3D human in vitro models, 2 and 3D imaging approaches, flow cytometry and ligand (MSD, ELISA) based assays.
We are looking for a highly collaborative cellular biologist with a passion for science who ideally has a background in fibrotic disease (Idiopathic Pulmonary Fibrosis, Systemic Sclerosis, Stricturing Crohn's Disease) with experience in measuring extracellular matrix levels and cell state. The successful applicant will benefit from extensive training and exposure to cutting edge technologies such as bioprinting, nanoshuttle assembly of cells, 3D laser imaging, CRISPR knockout and artificial intelligence based high content image assessment.
Mammalian cell culture of primary and transformed cells both in 2D and 3D systems
Immunofluorescent staining & 3D Imaging / quantification of human models including in 384 well screening format
As a member of the laboratory team, work together to ensure efficient running of the lab; ordering, waste management, calibration records, glassware stocking etc
Contribute to Health and Safety compliance (risk assessments, SOPs, COSHH, HTA)
Enter data into an electronic data capture system and write-up ELN as required
A recent PhD in immunology or fibrotic disease (or equivalent), OR a BSc / MSc in a relevant area of cell biology with demonstrable experience in industry/biotech of Drug Discovery or Academia
Experience of solving technical problems in assay development to achieve key project objectives and adhere to timelines.
Excellent communication skills, including report writing and verbal presentations of findings
Ability to work independently yet with a collaborative style with colleagues and project teams within Mestag and with external partners.
Excellent communication, including report writing and presentation skills.
We work flexibly with a strong team spirit and offer a highly competitive total rewards package including competitive salaries, super pension contributions, private medical insurance, income protection, learning and development and more.
We have access to a range of onsite facilities including a gym, canteen, golf course, park walks and free on site parking.
We value the relationships of our close-knit team and strive to make meaningful connections in our community. We frequently hold Town Halls and team lunches, and have an active social committee, organizing regular events and 'giving back' activities supporting charities close to our hearts.
Together with our collaboration partner Janssen Biotech, Inc. we are also identifying novel targets for future therapies.
Our founding investigators comprise global experts in inflammatory disease, cancer, computational biology and fibroblast biology from the University of Oxford, Brigham & Women's Hospital, Harvard Medical School and Cold Spring Harbor Laboratory. We are supported by leading life science investors SV Health Investors, Johnson & Johnson Innovation - JJDC, Inc., Mestag is headquartered in Cambridge, UK, and in 2021 was recognized on the Fierce 15 list of innovative biotechnology companies.
For further information please visit our website
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