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Slough, Slough, United Kingdom Lifelancer Full time{"title": "DMPK Project Lead", "description": "Job SummaryWe are seeking a highly skilled DMPK Project Lead to join our team at Lifelancer. As a key member of our research organization, you will be responsible for leading projects from early discovery to clinical phases, with a focus on nonclinical DMPK activities.Key ResponsibilitiesDesign and execute...
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Slough, Slough, United Kingdom Lifelancer Full time{"title": "DMPK Project Lead", "description": "Job SummaryWe are seeking a highly skilled DMPK Project Lead to join our team at Lifelancer. As a key member of our research organization, you will be responsible for leading projects from early discovery to clinical phases, with a focus on nonclinical DMPK activities.Key ResponsibilitiesDesign and execute...
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Slough, Slough, United Kingdom Lifelancer Full timeJob Title: DMPK Project LeadWe are seeking a highly skilled DMPK Project Lead to join our team at Lifelancer. As a key member of our research and development organization, you will be responsible for leading projects from early discovery to clinical phases, focusing on nonclinical DMPK activities.Key Responsibilities:Design and execute experimental studies...
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DMPK Project Lead
2 days ago
Slough, Slough, United Kingdom Lifelancer Full timeJob Title: DMPK Project LeadWe are seeking a highly skilled DMPK Project Lead to join our team at Lifelancer. As a key member of our research and development organization, you will be responsible for leading projects from early discovery to clinical phases, focusing on nonclinical DMPK activities.Key Responsibilities:Design and execute experimental studies...
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DMPK Project Lead
2 days ago
Slough, Slough, United Kingdom Lifelancer Full timeJob Title: DMPK Project LeadWe are seeking a highly skilled DMPK Project Lead to join our team at Lifelancer. As a key member of our research and development organization, you will be responsible for leading projects from early discovery to clinical phases, focusing on nonclinical DMPK activities.Key Responsibilities:Design and execute experimental studies...
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Slough, Slough, United Kingdom Lifelancer Full timeJob Title: DMPK Project LeadWe are seeking a highly skilled DMPK Project Lead to join our team at Lifelancer. As a key member of our research organization, you will be responsible for leading projects from early discovery to clinical phases, ensuring the successful development of new compounds.Key Responsibilities:Design and execute experimental studies to...
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DMPK Project Lead
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DMPK Project Lead
4 days ago
Slough, Slough, United Kingdom Lifelancer Full timeJob Title: DMPK Project LeadWe are seeking an experienced DMPK Project Lead to join our team at Lifelancer. As a key member of our research organization, you will be responsible for leading projects from early discovery to clinical phases, ensuring the successful development of new compounds.Key Responsibilities:Design and execute experimental studies to...
DMPK Project Lead
4 months ago
Make your mark for patients
We are looking for a DMPK Project Representative who is curious and innovative to join us in our Quantitative Discovery & Development team, based at our research site in Slough, UK or Braine L'Alleud, Belgium.
About the role
The DMPK project representative is a critical role in our R&D activities, and we are looking to recruit a senior individual with expertise in discovery and development DMPK science, preferably covering multiple modalities beyond NCE including TPD, ASO and peptides.
Who you'll work with
The individual will have project responsibility for early discovery towards candidate selection and into the clinical phases of the development. They will be responsible for the project aspects of nonclinical DMPK including in vitro and in vivo activities, pre-clinical PK, translational PK and PK-PD, biotransformation and bioanalysis contributions to projects to fulfil internal and regulatory requirements up to and including registration.
What you'll do
Design appropriate experimental studies and liaise with other areas of the R&D organization organization to deliver data and interpretations to support the project towards candidate selection and beyondHave expert understanding of the different approaches related to preclinical pharmacokinetics, as well as a good understanding of related disciplines (e.g., toxicokinetics, nonclinical safety, PKPD, PK modelling, drug design, clinical DMPK, bioanalytics and biomarkers)Apply their understanding of physical properties, DMPK and enzymology to input into the design of new compoundsWork with the project and Development Sciences colleagues to resolve or risk-mitigate project-related ADME challengesWork with other areas in the DMPK organization to champion new, innovative approaches to project support and ensure UCB stays at the forefront of DMPK sciencePrepare the DMPK sections of internal and regulatory documents (e.g. IND, IMPD, IB, NDA)Participate in research aligned to DMPK and UCB's portfolio to publish research papers in internationally recognized journalsProvide scientific mentorship to support junior staff in their personal developmentInterested? For this role we're looking for the following education, experience, and skills
PhD (or equivalent) in Pharmaceutics, Pharmacology, Drug metabolism or Pharmacokinetics, with > 7 years of Post-Doctoral Industrial experience; or a related degree with > 10 years industrial experience in DMPK science. A comprehensive understanding of discovery and development DMPK including modelling and simulation and a proven ability to delineate the impact of chemical structure on measured propertiesWide experience in pharmaceutical R&D including a knowledge of the regulatory requirements and experience working with regulatory agencies to fulfil the DMPK contribution to new drug submissionsA recognized track record of experience in DMPK/ADME and excellent knowledge in ADME/Enzymology/Drug Transporters and knowledge of how to couple data to optimization/selection of NCE, both in discovery and developmentA proven track record of leading, understanding and hands-on experience of drug metabolism and pharmacokinetics, both in vitro and in vivo studies, human PK prediction, DDI prediction and mechanistic understanding to support late-stage programsUnderstanding of PKPD and preferably an understanding of PBPK modeling Proven skills for in depth mechanistic understanding of DMPK related issues and of the impact and value of translation to humansKnowledge of the drug development processes in the Pharma Industry environment.If you are interested to learn more about R&D within UCB, please find more information here R&D at UCB.
RANDATUCB
Are you ready to 'go beyond' to create value and make your mark for patients? If this sounds like you, then we would love to hear from you
About us
UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are around 8,500 people in all four corners of the globe, inspired by patients and driven by science.
Why work for us?
At UCB, we don't just complete tasks, we create value. We aren't afraid to push forward, collaborate, and innovate to make our mark for patients. We have a caring, supportive culture where everyone feels included, respected and has equitable opportunities to do their best work. We 'go beyond' to create value for our patients, and always with a human focus, whether that's on our patients, our employees or our planet. Working for us, you will discover a place where you can grow, and have the freedom to carve your own career path to achieve your full potential.
Learn more about sustainability at UCB and how it is integrated into our business approach.
UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. We do not discriminate on the basis of race/colour/religion/sex/national origin/veteran/disability/age/sexual orientation/gender identity.
