PhD Studentship: AI and Graph Theory to Model Small Molecules: The Next Frontier in Chemical Space

Primary Supervisor: Dr James Smith Cardiomyocytes are the muscle cells of the heart, responsible for the production of contraction forces. During development, cardiomyocytes withdraw from the cell-cycle and switch from proliferative, growth to non-proliferative, hypertrophic growth. It is becoming clear that the extracellular matrix molecules play a key role...

Primary Supervisor: Dr Rianne Lord Bacterial infections are the second-leading cause of deaths globally, and whilst antibiotics have undoubtedly saved millions of lives, their extensive use, coupled with pathogen evolution has resulted in drastic increases in prevalence of antibiotic-resistant strains. Amongst these, Gram-negative pathogens pose the most...

Primary supervisor - Dr Dmitry Ghilarov BackgroundThe acute problem of antimicrobial resistance incentivises us to develop innovative approaches to antibiotic discovery & production. Natural products that form the basis of our current medical arsenal are often difficult to synthesize, purify, or engineer. In recent years bioinformatically predicted peptide...

Primary supervisor - Dr Amit SachdevaSecondary supervisor - Prof Andy CammidgeOver the last decade, several antibody-based biotherapeutics have been developed for treatment of cancer. These antibodies often bind to cell surface receptors on cancer cells and direct them towards apoptosis (programmed cell death). Though full-length antibodies have demonstrated...

Primary supervisor - Dr Myriam Charpentier Nitrogen (N) acquisition is fundamental for plant growth. However, N is poorly available in soils, leading to extensive and costly chemical fertiliser applications. It is estimated that 50-70% of nitrogen-derived fertilizer provided to the soil is lost, giving rise to soil and water pollution as well as global...

Primary supervisor - Dr Andrew Gates As well as carbon dioxide (CO2), other important climate-active gases are known to drive global warming. Importantly, nitrous oxide (N2O), is the third most abundant greenhouse gas with 300-times greater global warming power than CO2 and it also contributes to the destruction of the ozone layer. Production of N2O is a...

Primary supervisor - Dr Neil HallTake-all is the most important root disease of wheat worldwide and is caused by the fungus Gaeumannomyces tritici. G. tritici belongs to an important group of grass-infecting pathogens including rice and wheat blast fungi (Magnaporthales, Ascomycota), but take-all of wheat is an understudied disease. Little is known about how...

Primary supervisor - Dr Fred Warren The infant gut is a complex, constantly adapting ecosystem which shows distinct shifts as a consequence of introducing solid foods, which can have lifelong health impacts. An important nutrient in weaning foods is starch, a key dietary component in the adult diet. The genus Bifidobacterium has several adaptations making it...

Primary supervisor - Professor Antony Dodd Climate change poses a significant threat to our food supply, but you can be part of the solution In this groundbreaking research project, we're investigating how plants adapt to changing seasons and temperatures, with a focus on ensuring robust crop production despite environmental challenges.You'll explore the...

Primary supervisor - Professor Martin Warren This PhD opportunity is ideal for graduates in biochemistry or biomedical science with a keen interest in protein science and its application in developing new diagnostic tests and assays. Recently, the National Institute for Health and Care Excellence (NICE) issued comprehensive guidelines on diagnosing and...

Primary supervisor - Professor Diane Saunders Wheat blast and rusts are fungal diseases that severely damage cereal production worldwide. During infection, these fungi secrete proteins into wheat plants to reprogramme host plant circuitry, supporting their own growth and development. A subset of effectors, termed avirulence factors (Avr), can be recognised...

Group B Streptococcus (GBS) is an effective pathogen of humans and animals and is well known as the leading cause of often-fatal infections in newborn infants. Little is known about how GBS resists the immune system and colonises to cause invasive disease. This PhD will develop a new understanding of how streptococci resist intoxication by metals, a major...

Primary supervisor - Dr Stephanie SchüllerColorectal cancer (CRC) is the third most common and second most fatal cancer globally. Most cases of CRC are not hereditary but influenced by lifestyle factors and changes in the gut microbiome. Importantly, 5-10% of CRCs have been linked to E. coli strains producing the metabolite colibactin which causes DNA...

Primary Supervisor: Professor Andrea Münsterberg Segmentation of the main body axis is a fundamental and conserved feature of all vertebrate embryos. It results in the metameric organization of the vertebral column and its associated muscles, nerves, and blood vessels. The vertebral column is produced by somites, transient aggregates of cells generated by...

Primary Supervisor: Dr. Rebecca Taylor Ageing is associated with increased rates of disease, including neurodegenerative conditions. Prion-like proteins (PrLPs) play major roles in age-associated neurodegeneration, but their physiological functions are often poorly understood. Defining these functions would increase our understanding of the behaviour and...

Primary supervisor - Dr Paul Crichton Mitochondria in our cells harness energy through the breakdown of nutrients to produce ATP through oxidative phosphorylation. However, in specialised brown adipose tissue, popularised as 'good fat', the conventional process is 'short circuited' by a mitochondrial membrane protein, UCP1, which allows the tissue to burn...

An exciting opportunity has arisen for a Senior Research Associate join the School of Pharmacy to conduct studies on the control of protein-protein interactions in ribosome biogenesis.A feature of cancer is an ability to grow rapidly, continuously, and uncontrollably. Cancer commonly achieves this by creating extra ribosome complexes, allowing for...

Salary on appointment will be £36,333 per annum, with an annual increment up to £43,155 per annum. We are seeking a post-doctoral Senior Research Associate to work with Dr Robert D. Gray on the EPSRC-funded project "Algorithmic, topological and geometric aspects of infinite groups, monoids and inverse semigroups".For further details of the project see:...

Salary on appointment will be £37,099 per annum, with an annual increment up to £44,263 per annum. An exciting opportunity has arisen for a Senior Research Associate to join the School of Computing Sciences and School of Pharmacy to conduct research on developing an AI ensemble system for analysing the snack creation/production data and processes and...

Applications are invited for a Research Scientist to join the Laboratory of Prof Anthony Hall in the Research Faculty of the Earlham Institute, based in Norwich, UK.Background:Earlham Institute is a vibrant research institute with a strong skill base in genomics technologies and bioinformatics. We deliver programmes to improve food security, advance...