Flow Cytometry/Immunologist Expert

Site Name: UK - Hertfordshire - Stevenage

Posted Date: Apr 4 2023

Flow Cytometry / Immunologist Expert

We are seeking a highly motivated scientist with experience in immunology/ immune oncology to join the Digital Biology Twin (DBT) lab in GSK. DBT has been newly set up in order to help clinical development for further pipelines and to contribute to preclinical development programmes within GSK. The successful candidate will work as part of a team that, exploiting patient-derived organoids, is developing and implementing cutting-edge cellular, genomic and molecular techniques with a multimodality analytic approach, plus machine learning models to improve cancer patient risk stratification as well as to predict future targeted and/or immuno-therapy susceptibilities.

These positions within the Digital Biological Twin (DBT) laboratory in GSK are created to assist clinical development of drug pipelines and to contribute to preclinical development programmes within GSK. Exploiting patient-derived organoids, the DBT lab will apply a multimodality analytic approach, plus machine learning models which are coupled with paired patient-derived data feedback, to provide mechanistic markers/novel pharmacodynamic readout, improve cancer patient risk stratification as well as to predict future targeted and/or immuno-therapy susceptibilities. The DBT lab is part of a new Unit (DBT) which has existing functional and strategic linkages with the other units on common Oncology related projects e.g. AI/ML, EMU, Genomic Science (GS), Clinical Imaging (CPEM) and Bio-imaging (IVIVT), etc.

Join our challenge to get ahead of disease together

In this role, you will also ensure synergy and collaboration between this new unit and KCL scientists within the GSK-King's College London (KCL) Translational Oncology Research Hub ), an exclusive research collaboration between GSK and the Comprehensive Cancer Centre at KCL.

In addition, you will interact with experts in other subject areas e.g. AI/ML, EMU, Development (e.g. Oncology team EDL & MDL), various Oncology-relevant Research Units (RU), functional genomics (FxG), proteomics, Clinical Imaging, etc., working together towards improving patient stratification of clinical treatments using GSK assets, alone or in combination with standard of care treatment.

In this role you will

• Defining, conducting and evaluating experiment for PBMC isolation, PBMC activation for allogenic/autologous coculture with organoids
• Defining and conducting and evaluating experiment to establish drug impact on immune cells in a 3d coculture setting
• Defining, conducting, and evaluating experiment with FACS analysis
• Defining and conducting immunopeptidome analysis
• Developing flowcytometry protocols and antibodies panels (up to 20 colours)
• Collecting and reporting data to the lab head.
• Interacting with imaging expert/team to define immune cells characterization
• Executing and delivering data of the project
• Solving technical issues operate as part of a cross-functional project team
• Collaborating with KCL scientists within the GSK-KCL Translational Oncology Research Hub, an exclusive research collaboration between GSK and the Comprehensive Cancer Centre at KCL.

Why you?

Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• BSc in Immunology/Immuno-oncology or related
• A multidisciplinary mix of training/expertise in immunology, oncology as well as integrative data analysis.
• Significant experience in immune cells characterization.
• Cellular and molecular Biology skills: immune cell isolation from human biopsies/samples; culture of normal and tumor cells from primary samples or immortalized cell lines; cell isolation from buffy coats; PBMC activation and characterization; immunopeptidome analysis; experience in 3D culture or coculture will be a plus.
• Flow cytometry and cell sorting (FACS up to 20 colours); proliferation, cell cycle and apoptosis assays.
• Ability to communicate with team members from different backgrounds by training/discipline, as well as senior members of the GSK stakeholders/research partner units
• Ability to deliver high quality, consistent results in a timely fashion with a positive can-do and result oriented attitude

Preferred Qualifications & Skills:

If you have the following characteristics, it would be a plus:

• MSc or PhD in Immunology/Immuno-oncology or related
• Experience of immune cell coculture with tumor cells
• A track record of scientific Publication
• Experience in collaboration with biopharma
• Proven experience of relevant immunological laboratory techniques

Why GSK?

Uniting science, technology and talent to get ahead of disease together

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

Find out more:

Annual Report 2022

Closing Date for Applications: Tuesday 18th April 2023 (COB)

Please take a copy of the Job Description, as this will not be available post closure of the advert.

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#LI-GSK

GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years.

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a workplace where everyone can feel a sense of belonging and thrive as set out in our Equal and Inclusive Treatment of Employees policy. We're committed to being more proactive at all levels so that our workforce reflects the communities we work and hire in, and our GSK leadership reflects our GSK workforce.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class(US only).

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