Senior Scientist
3 weeks ago
Contract: 12 month contract
Location: Slough
Salary: £28.09 - £33.58 PAYE
SRG are working with a Global Biopharmaceutical company to help them find a Senior Scientist to join their busy team. This is an exciting opportunity for an individual experienced in protein analysis.
You will be part of the Protein Production Group playing a key role in project success by generating high quality protein reagents in a timely manner. You will also assist with antibody discovery.
The successful candidate will have the opportunity to rapidly impact on a wide range of our NBE & NCE projects, and to significantly contribute to the progression of these projects into the clinic and beyond.
Key Responsibilities will include:
You will be responsible for expressing and purifying high-quality recombinant protein reagents to support UCB's novel world-leading antibody and NCE drug discovery platforms for a variety of exciting therapeutic projects.
You will have an excellent and proven track record of protein reagent delivery.
You will use your excellent practical skills, communication and team working abilities to drive innovative projects forward from the laboratory.
You will be responsible for clearly presenting work and engaging in discussion in a variety of cross-functional and external collaborator meetings.
Candidate Requirements:
Candidates will have extensive experience (PhD holder or graduate with 4-5 years) in protein biochemistry, focusing on recombinant protein production.
Molecular Biology (DNA manipulation techniques and comprehensive knowledge and experience with software used in manipulating protein and DNA sequences (VNTI) and molecular visualisation of proteins (PyMOL or similar).
Proficient in E.coli, insect and mammalian cell expression systems (and experience in 15N, 13C and 2H labelled expression in E.coli)
Fully independent in protein purification techniques (affinity, ion exchange, hydrophobic interaction chromatography, size exclusion chromatography, analytical SEC, UV-Vis spectroscopy, and protein refolding techniques) and extensive experience working with AKTA purification platforms and associated software.
Fully competent in protein characterisation techniques: SDS-PAGE, Western blot, analytical SEC, UV-Vis spectroscopy and UPLC.
Excellent biochemistry knowledge with hands on experience of protein labelling and characterisation.
Good understanding of recombinant protein expression systems and the molecular biology involved in generating expression constructs.
Thorough knowledge of the latest technologies involved in protein purification.
Track record of recombinant protein production covering multiple protein classes including enzymes, structural proteins, cell signalling factors, cell surface receptors and their ligands produced as intracellular and secreted proteins.
Ability to work on several projects and conduct experiments in parallel.Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy
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