Dmpk Project Lead

2 weeks ago

Slough, Slough, United Kingdom UCB S.A. Full time

Make your mark for patients


We are looking for a
DMPK Project Representative who is curious and innovative to join us in our Quantitative Discovery & Development team, based at our research site in
Slough, UK or
Braine L'Alleud, Belgium.


About the role


The DMPK project representative is a critical role in our R&D activities, and we are looking to recruit a senior individual with expertise in discovery and development DMPK science, preferably covering multiple modalities beyond NCE including TPD, ASO and peptides.


What you'll do

  • Have expert understanding of the different approaches related to preclinical pharmacokinetics, as well as a good understanding of related disciplines (_e.g., _toxicokinetics, nonclinical safety, PKPD, PK modelling, drug design, clinical DMPK, bioanalytics and biomarkers)
  • Work with the project and Development Sciences colleagues to resolve or riskmitigate projectrelated ADME challenges
  • Work with other areas in the DMPK organization to champion new, innovative approaches to project support and ensure UCB stays at the forefront of DMPK science
  • Prepare the DMPK sections of internal and regulatory documents (e.g. IND, IMPD, IB, NDA)
  • Participate in research aligned to DMPK and UCB's portfolio to publish research papers in internationally recognized journals
  • Provide scientific mentorship to support junior staff in their personal development

Interested? For this role we're looking for the following education, experience, and skills

  • PhD (or equivalent) in Pharmaceutics, Pharmacology, Drug metabolism or Pharmacokinetics, with > 7 years of Post-Doctoral Industrial experience; or a related degree with > 10 years industrial experience in DMPK science.
  • A comprehensive understanding of discovery and development DMPK including modelling and simulation and a proven ability to delineate the impact of chemical structure on measured properties
  • Wide experience in pharmaceutical R&D including a knowledge of the regulatory requirements and experience working with regulatory agencies to fulfil the DMPK contribution to new drug submissions
  • A recognized track record of experience in DMPK/ADME and excellent knowledge in ADME/Enzymology/Drug Transporters and knowledge of how to couple data to optimization/selection of NCE, both in discovery and development
  • A proven track record of leading, understanding and handson experience of drug metabolism and pharmacokinetics, both in vitro and in vivo studies, human PK prediction, DDI prediction and mechanistic understanding to support latestage programs
  • Understanding of PKPD and preferably an understanding of PBPK modeling
  • Proven skills for in depth mechanistic understanding of DMPK related issues and of the impact and value of translation to humans
  • Knowledge of the drug development processes in the Pharma Industry environment.
Are you ready to 'go beyond' to create value and make your mark for patients? If this sounds like you, then we would love to hear from you

About us
UCB is a global biopharmaceutical company, focusing on neurology and immunology. We are around 8,500 people in all four corners of the globe, inspired by patients and driven by science.

Why work for us?
At UCB, we don't just complete tasks, we create value. We aren't afraid to push forward, collaborate, and innovate to make our mark for patients.

We have a caring, supportive culture where everyone feels included, respected and has equitable opportunities to do their best work.

We 'go beyond' to create value for our patients, and always with a human focus, whether that's on our patients, our employees or our planet.

Working for us, you will discover a place where you can grow, and have the freedom to carve your own career path to achieve your full potential.


Learn more about sustainability at UCB and how it is integrated into our business approach.

UCB and its subsidiaries encourage diversity and inclusion in the workplace; we are an Equal Opportunity Employer. We do not discriminate on the basis of race/colour/religion/sex/national origin/veteran/disability/age/sexual orientation/gender identity.

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