Current jobs related to Phd Studentship in The Infection, Immunology and - London, Greater London - University College London
-
Research Excellence PhD Studentship Opportunity
3 weeks ago
London, Greater London, United Kingdom University of East London Full timeResearch Excellence PhD Studentship OpportunityThe University of East London (UEL) invites applications from highly qualified and motivated students for Research Excellence PhD Studentships, fully waiving tuition fees, in various research areas.Research AreasESG Data AnalysisSustainable DevelopmentOpen FinanceHealthcare Data ManagementAbout the University of...
-
Research Excellence PhD Studentship Opportunity
3 weeks ago
London, Greater London, United Kingdom University of East London Full timeResearch Excellence PhD Studentship OpportunityThe University of East London (UEL) invites applications from highly qualified and motivated students for Research Excellence PhD Studentships, fully waiving tuition fees, in various research areas.Research AreasESG Data AnalysisSustainable DevelopmentOpen FinanceHealthcare Data ManagementAbout the University of...
-
PhD Research Scientist
5 days ago
London, Greater London, United Kingdom The Post At Mint Hill Llc Full timeJob Title: PhD Research ScientistWe are seeking a highly motivated and experienced PhD Research Scientist to join our team at The Post At Mint Hill Llc. The successful candidate will have a strong background in liver research, specifically in the areas of cancer immunology and mitochondrial medicine.Job Summary:The PhD Research Scientist will be responsible...
-
PhD Research Scientist
5 days ago
London, Greater London, United Kingdom The Post At Mint Hill Llc Full timeJob Title: PhD Research ScientistWe are seeking a highly motivated and experienced PhD Research Scientist to join our team at The Post At Mint Hill Llc. The successful candidate will have a strong background in liver research, specifically in the areas of cancer immunology and mitochondrial medicine.Job Summary:The PhD Research Scientist will be responsible...
-
PhD Research Scientist
2 days ago
London, Greater London, United Kingdom The Post At Mint Hill Llc Full timeJob Title: PhD Research ScientistWe are seeking a highly motivated and experienced PhD Research Scientist to join our team at The Post At Mint Hill Llc. The successful candidate will have a strong background in liver research, specifically in the areas of cancer immunology and mitochondrial medicine.Job Description:RS64: Cancer ImmunologyManage and...
-
PhD Research Scientist
2 days ago
London, Greater London, United Kingdom The Post At Mint Hill Llc Full timeJob Title: PhD Research ScientistWe are seeking a highly motivated and experienced PhD Research Scientist to join our team at The Post At Mint Hill Llc. The successful candidate will have a strong background in liver research, specifically in the areas of cancer immunology and mitochondrial medicine.Job Description:RS64: Cancer ImmunologyManage and...
-
PhD Research Scientist
6 days ago
London, Greater London, United Kingdom Michael Page (UK) Full timeAbout the RoleWe are seeking a highly skilled PhD Research Scientist to join our team at Michael Page (UK). As a key member of our clinical trials organisation, you will play a crucial role in developing and optimising scientific methods to deliver innovative research.Key ResponsibilitiesDevelop and validate a range of assays to support ongoing clinical...
-
PhD Research Scientist
7 days ago
London, Greater London, United Kingdom Michael Page (UK) Full timeAbout the RoleWe are seeking a highly skilled PhD Research Scientist to join our team at Michael Page (UK). As a key member of our clinical trials organisation, you will play a crucial role in developing and optimising scientific methods to deliver innovative research.Key ResponsibilitiesDevelop and validate a range of assays to support ongoing clinical...
-
PhD Research Scientist
3 days ago
London, Greater London, United Kingdom Michael Page (UK) Full timeAbout the RoleWe are seeking a highly skilled PhD Research Scientist to join our team at Michael Page (UK). As a key member of our clinical trials organisation, you will play a crucial role in developing and optimising scientific methods to deliver innovative research.Key ResponsibilitiesDevelop and validate a range of assays to support ongoing clinical...
-
PhD Research Scientist
3 days ago
London, Greater London, United Kingdom Michael Page (UK) Full timeAbout the RoleWe are seeking a highly skilled PhD Research Scientist to join our team at Michael Page (UK). As a key member of our clinical trials organisation, you will play a crucial role in developing and optimising scientific methods to deliver innovative research.Key ResponsibilitiesDevelop and validate a range of assays to support ongoing clinical...
-
Director of Immunology Development
5 days ago
London, Greater London, United Kingdom Pharma Search Full timeImmunology Clinical Development Leadership OpportunityWe are seeking a highly skilled and experienced Director / Senior Director Clinical Immunology to lead our Immunology Clinical Development plans. The successful candidate will possess a strong strategic vision, coupled with a positive and entrepreneurial attitude, able to inspire and lead others in...
-
Director of Immunology Development
5 days ago
London, Greater London, United Kingdom Pharma Search Full timeImmunology Clinical Development Leadership OpportunityWe are seeking a highly skilled and experienced Director / Senior Director Clinical Immunology to lead our Immunology Clinical Development plans. The successful candidate will possess a strong strategic vision, coupled with a positive and entrepreneurial attitude, able to inspire and lead others in...
-
Biomedical Scientist
2 days ago
London, Greater London, United Kingdom Synnovis Group LLP. Full timeJob Title: Biomedical Scientist - Immunology ResearchWe are seeking a highly skilled Biomedical Scientist to join our Immunology Research team at Synnovis Group LLP. As a key member of our team, you will be responsible for conducting research in immunology and psychiatry, with a focus on developing diagnostic assays and translating research methods into...
-
Biomedical Scientist
2 days ago
London, Greater London, United Kingdom Synnovis Group LLP. Full timeJob Title: Biomedical Scientist - Immunology ResearchWe are seeking a highly skilled Biomedical Scientist to join our Immunology Research team at Synnovis Group LLP. As a key member of our team, you will be responsible for conducting research in immunology and psychiatry, with a focus on developing diagnostic assays and translating research methods into...
-
Medical Director Immunology
2 days ago
London, Greater London, United Kingdom Novartis Farmacéutica Full timeJob Title: Lead Medical Product StrategistJob Summary:We are seeking a highly skilled and experienced Lead Medical Product Strategist to join our team at Novartis Farmacéutica. As a key member of our Immunology team, you will be responsible for leading and developing medical product strategies and activities in close collaboration with medical and...
-
Medical Director Immunology
2 days ago
London, Greater London, United Kingdom Novartis Farmacéutica Full timeJob Title: Lead Medical Product StrategistJob Summary:We are seeking a highly skilled and experienced Lead Medical Product Strategist to join our team at Novartis Farmacéutica. As a key member of our Immunology team, you will be responsible for leading and developing medical product strategies and activities in close collaboration with medical and...
-
London, Greater London, United Kingdom International Society for Industrial Ecology Full timeJoin Our Research TeamWe are seeking a highly motivated and talented PhD researcher to join our team at the International Society for Industrial Ecology. Our research focuses on the transition to a Circular Economy for Construction Materials, and we are looking for a candidate who shares our passion for sustainability and innovation.About the ProjectOur...
-
London, Greater London, United Kingdom International Society for Industrial Ecology Full timeJoin Our Research TeamWe are seeking a highly motivated and talented PhD researcher to join our team at the International Society for Industrial Ecology. Our research focuses on the transition to a Circular Economy for Construction Materials, and we are looking for a candidate who shares our passion for sustainability and innovation.About the ProjectOur...
-
Development Scientist
3 weeks ago
London, Greater London, United Kingdom Page Group Full timeAbout the RoleWe are seeking a highly skilled Development Scientist to join our team at Page Group, specializing in Virology and Immunology assay development. As a key member of our research team, you will be responsible for developing, optimizing, and validating a range of assays to support our clinical research projects.Key ResponsibilitiesAssay...
-
PhD Researcher: Aluminium Anode Development
3 days ago
London, Greater London, United Kingdom UCL Eastman Dental Institute Full timeJob DescriptionUCL Eastman Dental Institute is seeking a highly motivated and skilled PhD researcher to join our team in the Advanced Propulsion Lab. The successful candidate will be working on a project focused on the development of next-generation electrolyte systems for aluminium-based batteries.Key Responsibilities:Conduct research on the development of...
Phd Studentship in The Infection, Immunology and
3 months ago
Ref Number
B
Professional Expertise
Research and Research Support
Department
School of Life & Medical Sciences (B02)
Location
London
Working Pattern
Full time
Salary
See advert text
Contract Type
Fixed-term
Working Type
On site (> 80% of working time)
Available For Secondment
No
Closing Date
22-Feb-2024
About us:
A 3-year PhD Studentship in the Infection, Immunity and Inflammation Department, funded by the Rosetrees Trust, is available within the UCL GOS Institute of Child Health.
Project title:
Identification Of Druggable Targets In Pathways Common To Skin-replicating Viruses To Enable Future Development Of Broad-spectrum Antivirals
Hypothesis/Aims:
Our group is interested in viruses that are able to replicate in skin, including monkeypox (mpox), which has recently emerged as a major public health threat, herpes simplex virus (HSV) and varicella-zoster virus (VZV), which can cause severe disseminated infections, and human papillomavirus, the cause of cervical cancer.
In all cases replication in skin is critical to viral transmission and pathogenesis and the development of drugs and vaccines that interrupt viral replication in skin would have major benefits for their control.
Preliminary data suggest that, although from different viral families, these viruses replicate using the same proteins and signalling pathways, including some that are unique to skin and indeed, this may be what confers epithelial tissue tropism.
This project proposes to characterise in detail how herpes simplex and poxvirus (vaccinia and monkeypox) utilise common pathways to replicate in skin, identifying potential targets for the development of broad-spectrum antiviral therapies.
To this aim, we will:
- Characterise the transcriptome and proteome of HSV1 and vaccinia virus (VACV) in epithelial differentiation models.
- Characterise epidermal pathways that are critical for HSV1 and VACV epidermal replication.
- Identify inhibitors of the identified pathways and therefore of HSV1, VACV and mpox epidermal replication.
6-12 Month Plan (e.g.
, experimental approaches, data collection, preliminary analyses):
- training on different skin models
- training on HSV-1 and VACV viruses culture
- proteomics analyses of HSV-1 and VACV skin infections
Timeline
Year 1:
training in experimental models and proteomics analysis of HSV-1 and VACV skin infections.
Year2:
characterisation of pathways in HSV-1 and VACV skin infections
Year3:
testing of inhibitor drugs on HSV-1 and VACV skin infections and ultimately testing of selected inhibitors on mpox infections.
Research and Policy outputs:
Key output of this project will be a better understanding of how different skin viruses replicate in skin and identification of inhibitors that could pave the way for future development of broad-spectrum antivirals.
References:
- Jones M, Dry IR, Frampton D, Singh M, Kanda RK, Yee MB, et al. RNAseq Analysis of Host and Viral Gene Expression Highlights Interaction between Varicella Zoster Virus and Keratinocyte Differentiation.
PLOS Pathogens 2014;10:
e
- Tommasi C, Breuer J. The Biology of Varicella-Zoster Virus Replication in the Skin. Viruses 2022;14:98
- Tommasi C, Rogerson C, Depledge DP, Jones M, Naeem AS, Venturini C, et al. Kallikrein-Mediated Cytokeratin 10 Degradation Is Required for Varicella Zoster Virus Propagation in Skin.
J Invest Dermatol 2020;140:
e11.
About the role:
Environment:
The student will work within the UCL Great Ormond Street Institute of Child Health (UCL GOS ICH), with the Breuer research group and will join an international and highly collaborative environment.
Within Professor Breuer's group Dr Tommasi is working on VZV skin infection, two post-doctoral researchers are working on SARS-CoV-2 and other respiratory viruses and a post-doctoral researcher working on developing novel metagenomic methods.
In addition there are a further 4 computational post-doctoral researchers working on the evolutionary genomics of SARS-CoV-2, CMV, EBV and norovirus, a Henry Wellcome Fellow working on development of new metagenomic computational methods and one PhD student working on pathogen metagenomics.
In addition, there are two wet lab post-doctoral researchers working on development of metagenomics and the pathogenesis of CMV and EBV.
The student will learn about key aspects of HSV-1, VACV and monkeypox skin replication.
This Studentship presents a unique opportunity to conduct supervised research at and be a part of the research community, being an integral part of the exciting and thriving research team.
About you:
Applicants should have, or expect to receive an upper second-class Bachelor's degree, with a Master's degree (or equivalent work experience) in a relevant discipline or
