PhD Opportunity in Flow Crystallisation With In Situ X-Ray Diffraction

4 weeks ago

Harwell, United Kingdom University of Nottingham Full time

We are pleased to announce a PhD opportunity in flow crystallisation with in situ X-Ray diffraction. This multi-disciplinary PhD will combine reactor design, crystallisation, crystal engineering and data science. You’ll be joining a group of students developing a variety of flow apparatus for tailored needs. 

At Diamond Light Source, the UK's national synchrotron, we have developed world leading in situ flow crystallisation apparatus which enables us to monitor what we are crystallising as it is crystallising. By coordinating the flow of crystals within the crystalliser tubing with the movement of the whole crystalliser as the crystals pass the X-Ray beam, we can maximise the data which can be obtained from this dynamic environment. However, there are still great challenges to be overcome. 

Engineering challenges: Improve the robustness of the crystalliser towards blockages; Develop high-throughput delivery of compositional elements and optimise high-throughput environmental control. 

Materials / crystal engineering challenges: Simultaneously explore crystal structure and shape of pure and co-crystals of pharmaceuticals and pharmaceutical model compounds. 

Data Science challenges: Automated data solution of XRD with metadata for streamlined integration into growing international crystallisation database on crystallisation screening. 

The successful student will be based primarily at Diamond Light Source, Harwell Science Campus, Oxfordshire but will also spend time at the University of Nottingham. 

If you have a background in chemistry, materials, engineering and/or data science and are interested in this multi-disciplinary PhD opportunity please get in contact with Dr Karen Robertson (Karen.Robertson@nottingham.ac.uk) and Dr Sarah Day (sarah.day@diamond.ac.uk) for more details.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The Faculty of Engineering provides a thriving working environment for all PGRs creating a strong sense of community across research disciplines. Community and research culture is important to our PGRs and the FoE support this by working closely with our Postgraduate Research Society (PGES) and our PGR Research Group Reps to enhance the research environment for PGRs. PGRs benefit from training through the Researcher Academy’s Training Programme, those based within the Faculty of Engineering have access to bespoke courses developed for Engineering PGRs. including sessions on paper writing, networking and career development after the PhD. The Faculty has outstanding facilities and works in partnership with leading industrial partners. 

  • PhD Opportunity in Flow Crystallisation With In Situ X-Ray Diffraction

    4 weeks ago

    Harwell, Oxfordshire, United Kingdom University of Nottingham Full time

    We are pleased to announce a PhD opportunity in flow crystallisation with in situ X-Ray diffraction. This multi-disciplinary PhD will combine reactor design, crystallisation, crystal engineering and data science. You'll be joining a group of students developing a variety of flow apparatus for tailored needs. At Diamond Light Source, the UK's national...

  • PhD Position

    1 month ago

    Harwell, United Kingdom University of Salford Full time

    Ammonia is one of the most important bulk chemicals. In particular, through its use in the production of fertilizers it plays no small part in feeding the earth’s population, which has increased more than fourfold since industrial production of ammonia via the Haber-Bosch process has become possible. Environmentally friendly production of ammonia is thus a...

  • PhD Position

    1 month ago

    Harwell, Oxfordshire, United Kingdom University of Salford Full time

    Ammonia is one of the most important bulk chemicals. In particular, through its use in the production of fertilizers it plays no small part in feeding the earth's population, which has increased more than fourfold since industrial production of ammonia via the Haber-Bosch process has become possible. Environmentally friendly production of ammonia is thus a...

  • Molecular Biologist

    4 weeks ago

    Harwell, United Kingdom Medical Research Council – Mary Lyon Centre Full time

    Molecular Biologist **Medical Research Council - Mary Lyon Centre** **Harwell Campus, Oxfordshire** **Fixed Term until Until 31 March 2027** **£32,005 per annum** **About Us** **About the Role** The Mary Lyon Centre (MLC) at the Medical Research Council Harwell Institute requires a skilled molecular biologist to reinforce a busy service that provides...

  • Molecular Biologist

    4 weeks ago

    Harwell, Oxfordshire, United Kingdom MRC - Mary Lyon Centre Full time

    You will be based within established laboratories with significant genome engineering in the generation and quality control of engineered mouse alleles. You will work as part of a team on a collaborative technology development programme in Genome Editing and Engineering and be responsible for the design and validation of genome-engineered mouse models. You...

  • Molecular Biologist

    4 weeks ago

    Harwell, United Kingdom Medical Research Council Full time

    **Open Date** - 15/04/2024, 00:00 **Close Date** - 19/05/2024, 23:55 - Research Institute 1- MRC Mary Lyon Centre- Research Institute / Unit Information 1- The Mary Lyon Centre at MRC Harwell (MLC) is located in an expanding science and innovation campus in Oxfordshire and is an internationally renowned centre at the forefront of genetics research. As the...

  • Research Scientist

    4 weeks ago

    Harwell, Oxfordshire, United Kingdom MRC NATA Full time

    Harwell Campus, OxfordshireNucleic Acid Therapy AcceleratorThe Medical Research Council (MRC), as part of UK Research and Innovation (UKRI), has invested a total of £30m over 4 years to establish a nucleic acid therapy accelerator (NATA) that will support state-of-the-art interdisciplinary research to solve critical issues in nucleic acid drug delivery,...

  • Research Scientist

    1 month ago

    Harwell, United Kingdom MRC NATA Full time

    Harwell Campus, Oxfordshire Nucleic Acid Therapy Accelerator The Medical Research Council (MRC), as part of UK Research and Innovation (UKRI), has invested a total of £30m over 4 years to establish a nucleic acid therapy accelerator (NATA) that will support state-of-the-art interdisciplinary research to solve critical issues in nucleic acid drug delivery,...

  • Administrative Support

    4 weeks ago

    Harwell, United Kingdom Medical Research Council Full time

    **Open Date** - 14/07/2023, 12:20 **Close Date** - 06/08/2023, 23:55 - Research Institute- MRC Mary Lyon Centre- Research Institute / Unit InformationThe Medical Research Council (MRC) is a great place to work and progress your career. The MRC encourages the integration of clinical and discovery research to elucidate both disease processes and potential new...

  • Administrative Support

    4 weeks ago

    Harwell, United Kingdom MRC Harwell Full time

    The Administrative Support (Internal name: Export Coordinator) role will support Harwell’s standing as a national/international centre for mouse resources. Our clients include an extensive network of UK collaborators and overseas clients. The primary function of this role will be to coordinate the exportation of unique mouse models and other biological...