Molecular Biologist

**Open Date**
- 15/04/2024, 00:00

**Close Date**
- 19/05/2024, 23:55
- Research Institute 1- MRC Mary Lyon Centre- Research Institute / Unit Information 1- The Mary Lyon Centre at MRC Harwell (MLC) is located in an expanding science and innovation campus in Oxfordshire and is an internationally renowned centre at the forefront of genetics research. As the hub of the new National Mouse Genetics Network, the specialist facilities and capabilities of the MLC support a number of research groups across the UK to accelerate our understanding of human diseases, such as cancer, developmental disorders and neurodegeneration.-
- Band 1- MRC - 4- Location 1- Harwell Campus, Oxfordshire- Salary 1- £39,375-£43,962 per annum, dependent on skills and experience- Contract Type 1- Permanent- Job Type 1- Technical & Scientific Professionals- Full Time / Part Time 1- Full Time- Job Description 1**Overall Purpose**:
An understanding of gene structure and expertise in standard molecular biology techniques (PCR, sequencing) are required. Previous experience in the analysis of Sanger sequencing data is desirable. Specialist training in genome engineering can be provided.

**Main Duties/Key Responsibilities**:

- Design and validation of genome-edited mouse models
- Liaison with Genome Editing and Engineering Service users
- Coordination of molecular biology tasks in the MCB team and collaboration with other teams in the Mary Lyon Centre
- Review of data and production processes as part of a team
- Design of new engineered alleles
- Dissemination of knowledge in genome engineering, taking part in writing publications and teaching at specialist workshops

**Working Relationships**:

- Design and validate genome-engineered alleles for the generation of models, working as part of a team with the other Molecular and Cellular Biology (MCB) team members, including direct reports, and reporting to the Head of MCB
- Work with scientists in the various research groups, to help design alleles for new mouse models
- Interface with the senior team of the Mary Lyon Centre, including the Director and Heads of Departments, to deliver key programmes and services

**Additional Information**:
Some flexible working patterns and paid weekend work may be required at the discretion of the supervisor.
- Person Specification 1**Education/Qualifications/Training Required**:

- Essential: _
- PhD in Biological Sciences, or equivalent, involving the use of molecular biology
- Understanding of gene structure/function

**Previous Work Experience Required**:

- Essential: _
- Use or generation of genetically altered cell lines or animals
- Extensive use of PCR-based techniques
- Previous experience in genotyping
- Desirable: _
- Experience of Sanger sequencing or digital PCR
- Evidence of quality
- and customer-focused work

**Knowledge and Experience**:

- Essential: _
- Experience of several of the following Molecular and Cellular Biology techniques: gene targeting, genome editing, PCR, Sanger sequencing analysis, ddPCR, _in vitro_ transcription
- Computer literacy is essential for the recording and communication of results
- Desirable: _
- Working and adhering to standard operating procedures and experience of process analysis and refinement
- Experience in service provision

**Personal skills/Behaviours/Qualities**:

- Essential: _
- Organised and hard-working, with a strong eye for detail
- Able to work well as part of a team and develop leadership skills
- Desirable: _
- Able to communicate clearly and concisely with a variety of scientists at all levels (from principal investigator to research assistants and animal technicians)
- Further Information 1**Equality & Diversity**:
The MRC values the diverse skills and experience of its employees and is committed to achieving equality of treatment for all. Our objectives are that all individuals shall have equal opportunities for employment and advancement on the basis of their skills, aptitudes and abilities. The MRC is committed to the engagement and retention of the best possible talent and to creating an environment that encourages excellence in scientific research through good equality and diversity leadership and management.

**Corporate/Local Responsibilities & Requirements**:
The post-holder must at all times carry out their responsibilities with due regard to the MRC’s:

- Code of Conduct
- Equality and Diversity policy
- Health and Safety policy
- Data Protection and Security policy

The above lists are not exhaustive and the post-holder is required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, cooperatively and flexibly in line with the requirements of the post and the MRC.
- The MRC is a great place to work and progress your career, be it in scientific research or the support functions.The MRC is a unique working environment where our researchers are rewarded by world class innovation and collaboration o