Chief Science Officer

3 days ago

Oxford Oxfordshire, United Kingdom Immunocore Full time €75,000 - €90,000

IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
We strive to create a diverse and inclusive workplace, while seeking talented individuals to work with us across the many functions that will allow us to deliver new medicines to transform the lives of patients. You will work with outstanding people who together pioneer the research, development and commercialization of bi-specific TCR therapies. We aim to create an environment where individual contributions and initiatives can be maximized, while fostering a culture of collaboration, based on respect and integrity. We want each individual employee to own their career, as part of high-performing teams, and in the context of on-the-job and formal continuous development and training, as well as constructive feedback. We always strive to identify ways to improve what we do and how we do it, by asking questions, voicing opinions, exploring various approaches and staying connected with healthcare professionals, patients, academia and other key partners.
The Principal Scientist In Silico Biologics Design will provide world class expertise in machine learning to drive the establishment of robust in silico methodologies that integrates computational predictions with empirical laboratory data to revolutionise the design of our class-leading T-cell receptor (TCR) drugs. Using our wealth of structural data, combined with further in-house and public domain data sets, the successful applicant will develop ML algorithms to impact the design of future drugs. Working closely with the In Silico and automation teams within Protein Engineering, you will provide scientific and technical leadership relating to machine learning that will ultimately result in further progression of our growing pipeline of first-in-class drugs to benefit patients. With our successful launch in 2022, of the world's first TCR based medicine, KIMMTRAK, which is also the first launched treatment for any solid tumour, you will be joining us at the most exciting time in our history, and be part of a team that values innovation, trust and collaboration.
To develop and assess advanced machine learning (ML) models for novel antibody and TCR drug candidate optimisation and, looking to impact de novo drug design in the future
* Utilise our extensive in-house structural and specificity data sets to extract further value
* Work with colleagues across Research to identify training data from the public domain and help shape the development of our in-house data sets to support the optimisation of ML algorithms
* Drive the establishment of virtual screening tools including:
Assist with TCR library design for multifactorial lead optimisation
* Work with interdisciplinary teams across structural biology, next-generation sequencing (NGS), and bioinformatics and data science to integrate machine learning into TCR discovery and optimisation.
* Promote utilisation of ML algorithms among colleagues and mentor and train others in their deployment
* Present research outcomes at all levels, including Protein Engineering lab meetings, Research leadership team meetings, other governance meetings and at external conferences
Demonstrated ability to build and evaluate machine learning models
* At least 8 years of experience in antibody, TCR or biologics design, evidenced by a strong publication record.
* Advanced Python programming skills, focusing on data science and machine learning.
* Managed sizeable research projects, understanding the wider implications of project outcomes and strategic objectives.
* Demonstrates effective coaching skills and brings vision and strategy to life for others.
* Demonstrated ability to build and sustain networks and external collaboration with scientific leaders in the field.
Expertise in structural biology and modelling
* Experience in NGS analysis.
* Experience with biologics data management software including Genedata and in handling and integrating large-scale biological datasets from different sources.
* AWS)
PhD in Computational Biology, Computational Chemistry, Bioinformatics, or related discipline.

  • Chief Operating Officer

    2 days ago

    Oxford, United Kingdom Nfp People Full time

    Chief Operating Officer We are seeking a new Chief Operating Officer who shares the organisations passion for the work it does and who can provide strategic leadership and inspire staff to achieve its ambitious goals.Position: Chief Operating Officer Location: Oxford HQ (with hybrid working 2-3 days per week).International travel as required.Salary: From...

  • Chief Operating Officer

    3 days ago

    Oxford, United Kingdom Nfp People Full time

    Chief Operating Officer We are seeking a new Chief Operating Officer who shares the organisations passion for the work it does and who can provide strategic leadership and inspire staff to achieve its ambitious goals.Position: Chief Operating Officer Location: Oxford HQ (with hybrid working 2-3 days per week).International travel as required.Salary: From...

  • Chief Executive Office Administrator

    4 days ago

    Oxfordshire, United Kingdom OXFAM GB Full time

    Job OverviewOxfam GB is a leading organisation dedicated to ending poverty and inequality. We are seeking an exceptional professional to take on the crucial role of Chief Executive Office Administrator, ensuring the smooth operation of our CEO's office.About the RoleThis pivotal position requires a skilled individual with excellent interpersonal skills, able...

  • Science Leadership Program Manager

    3 weeks ago

    Oxfordshire, United Kingdom Schmidt Science Fellows Full time

    About Schmidt Science FellowsQualifications, skills, and all relevant experience needed for this role can be found in the full description below. We believe in a vision of a world where interdisciplinary science flourishes without limit, accelerating discoveries to benefit the world, and driving innovation that improves quality of life for all. We help...

  • Chief Data Officer

    4 days ago

    Oxford, Oxfordshire, United Kingdom Ellison Institute, LLC Full time

    Lead Data Innovation at Ellison InstituteEllison Institute, LLC is seeking a visionary Chief Data Officer to spearhead the development and management of its core data resources. This pivotal role will drive the creation of innovative data solutions and ensure seamless integration of high-quality genomic and clinical data for research and development.

  • Chief Science Officer

    4 days ago

    Oxford, Oxfordshire, United Kingdom Ellison Institute, LLC Full time

    About the Ellison Institute:We are seeking a highly experienced Director of Science Applications to lead our scientific development and implementation of the Pathogen Mission.The successful candidate will have a proven track record in leading the development of innovative whole-genome sequencing (WGS) applications in microbiology.Key...

  • Chief Executive Officer

    2 days ago

    Oxfordshire, United Kingdom Harris Hill Charity Recruitment Specialists Full time

    I am excited to be working with a fantastic mental health organisation in search of a freelance Chief Executive Officer. This is a part-time (35 hours a month) remote, freelance opportunity (long term rolling contract), with occasional travel to Oxford. As CEO you will be accountable to the Board of Trustees and responsible for providing leadership,...

  • Chief Executive Officer

    2 days ago

    Oxfordshire, United Kingdom Harris Hill Charity Recruitment Specialists Full time

    I am excited to be working with a fantastic mental health organisation in search of a freelance Chief Executive Officer. This is a part-time (35 hours a month) remote, freelance opportunity (long term rolling contract), with occasional travel to Oxford. As CEO you will be accountable to the Board of Trustees and responsible for providing leadership,...

  • Science Leadership Program Manager

    3 weeks ago

    Oxford, United Kingdom Schmidt Science Fellows Full time

    About Schmidt Science Fellows We believe in a vision of a world where interdisciplinary science flourishes without limit, accelerating discoveries to benefit the world, and driving innovation that improves quality of life for all.We help scientists solve bigger problems faster by identifying, developing, and amplifying the next generation of science leaders,...

  • Chief Financial Officer

    5 days ago

    Oxford, Oxfordshire, United Kingdom Robert Walters UK Full time

    Job SummaryWe are seeking a highly experienced Chief Financial Officer to lead our finance team in setting up a professional and compliant finance function. As a key member of the finance department, you will take ownership over the finance and supporting business operations, building your own financial admin infrastructure and taking responsibility for...

  • Science Leadership Program Manager

    3 weeks ago

    Oxford, United Kingdom Schmidt Science Fellows Full time

    About Schmidt Science Fellows We believe in a vision of a world where interdisciplinary science flourishes without limit, accelerating discoveries to benefit the world, and driving innovation that improves quality of life for all. We help scientists solve bigger problems faster by identifying, developing, and amplifying the next generation of science...

  • Science Leadership Program Manager

    3 weeks ago

    Oxford, United Kingdom Schmidt Science Fellows Full time

    Job Description About Schmidt Science Fellows We believe in a vision of a world where interdisciplinary science flourishes without limit, accelerating discoveries to benefit the world, and driving innovation that improves quality of life for all. We help scientists solve bigger problems faster by identifying, developing, and amplifying the next generation...

  • Chief Governance Officer

    6 days ago

    Oxford, Oxfordshire, United Kingdom Oxford Pride Full time

    **Job Title:** Chief Governance OfficerWe are seeking a highly skilled and experienced individual to join our Board of Trustees as Chief Governance Officer. This is a unique opportunity to play a key role in shaping the strategic direction of Oxford Pride, a charity that serves the LGBTQ+ community in Oxford.The successful candidate will have excellent...

  • Chief Commercial Officer

    2 days ago

    Oxford, Oxfordshire, United Kingdom Glen Callum Associates Ltd Full time

    Job Title: Chief Commercial OfficerLocation: Central UK (c. £75,000)Glen Callum Associates Ltd is seeking a skilled General Manager / Sales Management professional to lead our Aftermarket services through various channels.Main Responsibilities:Drive sales growth in the Aftermarket segmentDevelop and implement effective distribution strategiesBudget...

  • Chief of Staff

    3 months ago

    Oxfordshire, United Kingdom Marcilly Recruitment Ltd Full time

    Chief of Staff Job Description Marcilly Recruitment is seeking an extremely high-calibre Chief of Staff for a global family office with business interests spanning tech, luxury, hospitality, manufacturing, automobiles and conservation to name a few. The successful Chief of Staff will be responsible for overseeing all of their business and private affairs...

  • Chief Operational Officer

    4 days ago

    Oxford, Oxfordshire, United Kingdom The Gospel Coalition Full time

    Role SummaryThis is a unique opportunity for a strategic thinker to lead our operations and partnerships team. As Chief Operational Officer, you will be responsible for overseeing the day-to-day operations of our organisation, including managing budgets, coordinating projects, and developing policies.About Our OrganisationThe Gospel Coalition is a network of...

  • Chief Operating Officer

    5 days ago

    Oxford, United Kingdom Crosslight Full time

    About the RoleAs Chief Operating Officer at Crosslight, you will be responsible for co-leading and implementing the organisation's strategy, providing operational and fiscal oversight, and managing a team of senior professionals. The ideal candidate will have a minimum of 15 years of professional experience, with at least 8 years in senior leadership roles...

  • Science Leadership Program Manager

    3 weeks ago

    Oxfordshire, OX1 3RG, Oxford, United Kingdom Schmidt Science Fellows Full time

    About Schmidt Science Fellows We believe in a vision of a world where interdisciplinary science flourishes without limit, accelerating discoveries to benefit the world, and driving innovation that improves quality of life for all. We help scientists solve bigger problems faster by identifying, developing, and amplifying the next generation of science...

  • Chief Financial Officer

    2 days ago

    Oxford, Oxfordshire, United Kingdom Recruitment Revolution Full time

    About the Role:We are seeking a Chief Financial Officer to join our team at Recruitment Revolution, bringing financial insight and operational excellence to support our growth and customer service standards.Key Responsibilities:Provide strategic financial guidance to inform business decisionsOversee financial planning, budgeting, and forecasting...

  • Chief Technology Officer

    1 week ago

    Oxford, Oxfordshire, United Kingdom Zenoot Ltd Full time

    At Zenoot Ltd, we are seeking an exceptional Chief Technology Officer to develop a high-performance engineering consultancy. As a key member of our team, you will play a pivotal role in leading and overseeing technical projects for customers.Key ResponsibilitiesManage the technical team and projects to achieve coordinated design solutions that meet and...