Senior Research Scientist

4 weeks ago

Slough, United Kingdom Next-Link Full time
we seeking an experienced scientist specialising in HDX-MS to join our Mass Spectrometry team within the Protein Structure and Biophysics Group in Slough, UK. The MS team provides critical project support from initial adoption into the portfolio through to candidate selection of NBE and NCE therapeutics generated from our discovery platforms. Structural and mechanistic understanding of target and therapeutic molecule interactions are driven by our department using Mass Spectrometry, Cryo-EM, X-ray crystallography, SAXS, NMR and other biophysical techniques. The successful candidate will have a proven track record in the design and execution of HDX-MS experiments with a contextual understanding of their results alongside other structural data. We require someone who can quickly integrate into our team, manage and prioritise the demands from multiple projects, communicate clearly and will enjoy working within a highly motivated and multidisciplinary department

Requirements

Essential Experience


• PhD or BSc with 5+ years of relevant laboratory-based experience in the design, execution and analysis of HDX-MS experiments for antibody/protein/ligand interactions
• Experienced with Waters data processing software packages (PLGS) and DynamX™
• Practical knowledge Waters HDX-MS system
• Use of structural visualisation tools (PyMOL, Chimera or similar)
• Experienced with HDX-MS experiments using NBE and NCE molecules
• Excellent organisational, communication, record keeping and team-working abilities

Desirable Experience
• HDX-MS analysis of membrane proteins
• Troubleshooting and maintenance of Waters LC/MS equipment
• Practical ability with Native MS, ion mobility MS, SEC-MS or intact mass LC/MS
• Proven track record of publications related to mass spectrometry in peer reviewed journals
• Appreciation of recombinant protein expression systems and PTMs
• Working knowledge of Thermo Scientific Orbitrap MS systems

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