Senior Scientist: Molecular Assay Development

6 months ago

London, United Kingdom ProtonDx Full time

ProtonDx is a dynamic and innovative Imperial College London spin-out, specialising in medical diagnostics and related technologies.  With the recent launch of our regulatory-approved Point-of-Care Diagnostic product, Dragonfly, and a nucleic acid extraction kit for research use, SmartLid, we are poised for rapid growth and expansion into new product lines and strategic partnerships. We are committed to pushing the boundaries of science and technology to improve healthcare outcomes. 

 

We are looking for a Senior Scientist with significant experience in the design, development, and evaluation of molecular assays, ideally in the context of isothermal amplification chemistries, including LAMP. 

 

KEY RESPONSIBILITIES: 

 

  • Develop and validate highly sensitive and specific in vitro molecular assays (including LAMP) for the detection of pathogens associated with humans, animals, plants and other areas. 
  • Experienced on phylogenetic/genomic analysis for comparative analysis of the specificity (inclusivity and exclusivity) of the designed molecular assays. 
  • Contribute to scientific R&D projects through hands-on design, execution, and analysis of laboratory experiments. 
  • Conducting regular in silico analysis and reports of designed assays against evolving target pathogens, including design and maintenance of necessary bioinformatics tools, and reporting. 
  • Resolve complex technical challenges in line with clinical diagnostic assay requirements, while adhering to published regulatory standards and guidance. 
  • Accurately record and present scientific results through the completion of laboratory records, written reports, and presentations. 
  • Preparation and QC of master mixes and reagents for production of CE-marked and RUO products. Undertake additional ad hoc / project work as required. 

Requirements

  • PhD in a relevant life science discipline such as Microbiology, Genomics, Molecular Biology, or Biochemistry. 
  • Significant experience (5+ years) in molecular assay development and optimisation, particularly in the context of LAMP, and ideally within an IVD / diagnostics industry environment.  
  • Experience in relevant laboratory techniques including: PCR, LAMP, and nucleic acid extraction and optimization; processing biological samples. 
  • Experience working to strict quality standards and in regulated environments (ISO 13485, UK MDR, IVDR, etc.). 
  • A solid understanding of bioinformatics tools and methodologies, expertise in using computational methods to analyse genetic sequences. 
  • Experience leading projects and independently delivering against agreed timescales and outputs. 
  • An agile mind-set, happy working within a fast-moving R&D environment with evolving priorities. 
  • Excellent communication skills and a personable nature to support relationship building within the team and with key stakeholders. 
  • Laboratory experience in the following areas would be desirable: working in a regulated environment; infectious disease and antimicrobial resistance; precision serial dilutions; DNA sequencing; working with a containment level 2 facility; using automated molecular diagnostic systems; next generation sequencing; advanced multiplex applications; digital PCR.  
  • Experience line managing and/or leading /mentoring small teams would be beneficial although not essential. 

Reports to: Head of Product Development & CSO

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