Senior Scientist – Biocatalysis
2 weeks ago
Job Title: Senior Scientist – Biocatalysis
Macclesfield
Introduction to role:
Join our Early Chemical Development group as a Senior Scientist - Biocatalysis, where you'll be part of a team that transforms molecules into investigative medicines. Our work spans from early engagement with Discovery Chemistry groups to the manufacture of Phase II Clinical material. We're looking for a dedicated scientist to be a key member of the biocatalysis team, bringing a strong understanding of applied biocatalysis to the design and development of robust enzymatic processes for the manufacture of drug substances.
Accountabilities:
As a lab-based scientist, you will identify, develop and scale-up processes throughout the portfolio by finding opportunities for the application of enzymes in drug substance manufacturing. You’ll perform screening for selected opportunities, develop and implement reactions at multi-gram scale to enable early manufacturing either in-house or via outsourced work at CMOs/CROs if appropriate. You will also contribute to the success of AZ’s biocatalysis team, maintain up-to-date knowledge of technical advances in biocatalysis, and deliver enzymatic steps for drug substance manufacturing according to project timelines.
Essential Skills/Experience:
Degree, advanced degree or equivalent scientific qualification in a relevant subject area Proven experience of biocatalysis with a track record of delivery and creativity Proven problem solver with in-depth technical skills Functional expertise in applying biocatalysis at gram scale and using synthetic organic chemistry to make substrates/standards as appropriate Knowledge and application of analytical chemistry and assay selection/development such as MS, ELSD, NMR and other techniques required to evaluation enzyme performance Understanding and practice of applying GLP and SHE working in the laboratory Excellent written and verbal communication skills in EnglishDesirable Skills/Experience:
An awareness of green chemistry and sustainability principles and tools and their application towards the development and manufacture of drug substances Understanding of the overall drug development process from discovery through to launch Experience of discovery and early development phases of the drug development process and the contribution Pharmaceutical Development makes to the development and launch of medicinesWhen we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. This is a lab based role working five days per week from the office. But that doesn't mean we’re not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.
Why AstraZeneca?
Join us at AstraZeneca's Biopharmaceuticals R&D unit where we are unlocking the power of what science can do. We are working towards treating, preventing, modifying and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference by fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.
Are you ready to follow the science and be part of a team that makes a bigger impact on patients' lives? If your passion is science and you want to be part of a team that makes a bigger impact on patients' lives, then there's no better place to be. Apply now and join us in our mission to push the boundaries of science to deliver life-changing medicines
We encourage your application before 17th May 2024 and will be reviewing applications as and when they come through to us.
Date Posted
25-Apr-2024Closing Date
16-May-2024Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.-
Bioanalytical Scientist
2 months ago
Macclesfield, United Kingdom Hyper Recruitment Solutions Ltd Full timeAre you an experienced bioanalytical scientist or senior scientist looking for a new exciting job opportunity? We are currently looking for a number of Bioanalytical Scientists to join a rapidly expanding scientific company based in the Cheshire area. As a bioanalytical scientist, you will be primarily laboratory-based, working with the team to ensure that...
-
Senior Scientist
7 days ago
Macclesfield, United Kingdom Kenton Black Full timeJob Title: Scientist Role: Scientist role at agrowing Bioanalytical Contract Research Organisation (CRO) specialising in LC/MS/MS and LBA bioanalytical services to support drug discovery and regulatory development programs. The Scientist will participate in method development, validation, and routine sample analysis, ensuring compliance with GLP/GCP...
-
Senior Scientist
4 days ago
Macclesfield, Cheshire, United Kingdom Albion Rye Associates Limited Full time2 days ago Be among the first 25 applicants Direct message the job poster from Albion Rye Associates Recruitment Consultant | Supporting Biotech’s in the UK | Specialising in R&D My client is a fast-growing Contract Research Organisation (CRO) located near Macclesfield. They provide specialist bioanalytical services to support discovery and regulatory...
-
Senior Scientist
2 weeks ago
Macclesfield, United Kingdom AstraZeneca Full timeSenior Scientist - Pharmaceutical Sciences Macclesfield Salary & Benefits Competitive Introduction to Role: Join our Early Chemical Development (ECD) group in Pharmaceutical Sciences (PS), Macclesfield Campus, UK, as a laboratory analytical scientist in drug substance development. We are looking for a scientist who is enthusiastic, motivated,...
-
Senior Scientist
7 days ago
Macclesfield, Cheshire, United Kingdom Kenton Black Full time €25,000 - €32,000Job Title: Scientist Role: Scientist role at agrowing Bioanalytical Contract Research Organisation (CRO) specialising in LC/MS/MS and LBA bioanalytical services to support drug discovery and regulatory development programs. The Scientist will participate in method development, validation, and routine sample analysis, ensuring compliance with GLP/GCP...
-
Lead Scientist
4 weeks ago
Macclesfield, United Kingdom taylorollinson Ltd Full time**Lead Scientist - Drug Discovery** **Location** - Cheshire - Hybrid Role **Sector** - Drug Discovery **Salary**: - £60,000 - £70,000 **Contract**: - Full Time and Permanent Opportunity Our client is a leading company, offering research services to the Drug Discovery sector. They collaborate with lead researchers and organisations to enhance the...
-
Associate Principal Scientist or Principal
2 weeks ago
Macclesfield, United Kingdom AstraZeneca Full timeLocation: Gothenburg or Macclesfield **Make a more meaningful impact to patients’ lives around the globe** Here you’ll have the opportunity to make a meaningful difference to patients’ lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines - for the world’s most complex diseases....
-
LC-MS Bioanalytical Scientist
2 weeks ago
Macclesfield, United Kingdom VRS Recruitment Full timeExciting opportunity for an experienced LC-MS Scientist to join a friendly and dynamic team, at an exciting time of expansion! Your primary responsibility will be to conduct a range of GLP/GCP regulated studies, running LC-MS/MS for pre-clinical and clinical bioanalysis and assisting with developing and validating methods. For senior candidates, you will...
-
Macclesfield, United Kingdom AstraZeneca Full timeSenior Analytical Scientist – 12 month fixed term contract Macclesfield, UK Salary & Benefits Competitive At AstraZeneca, you will be empowered to be innovative and creative where difference is valued. We thrive in a place where the brightest and most curious minds seamlessly come together in our inclusive environment. We continuously...
-
Scientist/Senior Scientist
15 hours ago
Macclesfield, United Kingdom Albion Rye Associates Full timeMy client is a fast-growing Contract Research Organisation (CRO) located near Macclesfield. They provide specialist bioanalytical services to support discovery and regulatory drug development programs. From small molecules to biomarkers, the facility boasts cutting-edge UPLC-MS/MS instruments alongside a suite of other analytical technologies. Due to the...
-
Senior Scientist
6 days ago
Macclesfield, United Kingdom Albion Rye Associates Full timeMy client is a fast-growing Contract Research Organisation (CRO) located near Macclesfield. They provide specialist bioanalytical services to support discovery and regulatory drug development programs. From small molecules to biomarkers, the facility boasts cutting-edge UPLC-MS/MS instruments alongside a suite of other analytical technologies. Due to the...
-
Senior Scientist
6 days ago
Macclesfield, United Kingdom Albion Rye Associates Full timeMy client is a fast-growing Contract Research Organisation (CRO) located near Macclesfield. They provide specialist bioanalytical services to support discovery and regulatory drug development programs. From small molecules to biomarkers, the facility boasts cutting-edge UPLC-MS/MS instruments alongside a suite of other analytical technologies. Due to the...
-
Senior Scientist
6 days ago
Macclesfield, United Kingdom Albion Rye Associates Full timeMy client is a fast-growing Contract Research Organisation (CRO) located near Macclesfield. They provide specialist bioanalytical services to support discovery and regulatory drug development programs. From small molecules to biomarkers, the facility boasts cutting-edge UPLC-MS/MS instruments alongside a suite of other analytical technologies. Due to the...
-
Senior Scientist
6 days ago
Macclesfield, United Kingdom Albion Rye Associates Full timeMy client is a fast-growing Contract Research Organisation (CRO) located near Macclesfield. They provide specialist bioanalytical services to support discovery and regulatory drug development programs. From small molecules to biomarkers, the facility boasts cutting-edge UPLC-MS/MS instruments alongside a suite of other analytical technologies. Due to the...
-
Senior Scientist
13 hours ago
Macclesfield, United Kingdom Albion Rye Associates Full timeMy client is a fast-growing Contract Research Organisation (CRO) located near Macclesfield. They provide specialist bioanalytical services to support discovery and regulatory drug development programs. From small molecules to biomarkers, the facility boasts cutting-edge UPLC-MS/MS instruments alongside a suite of other analytical technologies. Due to the...
-
Senior Scientist
6 days ago
Macclesfield, United Kingdom Albion Rye Associates Full timeMy client is a fast-growing Contract Research Organisation (CRO) located near Macclesfield. They provide specialist bioanalytical services to support discovery and regulatory drug development programs. From small molecules to biomarkers, the facility boasts cutting-edge UPLC-MS/MS instruments alongside a suite of other analytical technologies. Due to the...
-
Senior Scientist
6 days ago
Macclesfield, United Kingdom Albion Rye Associates Full timeMy client is a fast-growing Contract Research Organisation (CRO) located near Macclesfield. They provide specialist bioanalytical services to support discovery and regulatory drug development programs. From small molecules to biomarkers, the facility boasts cutting-edge UPLC-MS/MS instruments alongside a suite of other analytical technologies. Due to the...
-
Senior Scientist
7 days ago
Macclesfield, United Kingdom Albion Rye Associates Full timeMy client is a fast-growing Contract Research Organisation (CRO) located near Macclesfield. They provide specialist bioanalytical services to support discovery and regulatory drug development programs. From small molecules to biomarkers, the facility boasts cutting-edge UPLC-MS/MS instruments alongside a suite of other analytical technologies. Due to the...
-
Senior Scientist
5 days ago
Macclesfield, United Kingdom Albion Rye Associates Full timeMy client is a fast-growing Contract Research Organisation (CRO) located near Macclesfield. They provide specialist bioanalytical services to support discovery and regulatory drug development programs. From small molecules to biomarkers, the facility boasts cutting-edge UPLC-MS/MS instruments alongside a suite of other analytical technologies. Due to the...
-
Senior Scientist
5 days ago
Macclesfield, UK, Cheshire, United Kingdom Albion Rye Associates Full timeMy client is a fast-growing Contract Research Organisation (CRO) located near Macclesfield. They provide specialist bioanalytical services to support discovery and regulatory drug development programs. From small molecules to biomarkers, the facility boasts cutting-edge UPLC-MS/MS instruments alongside a suite of other analytical technologies. Due to the...