Current jobs related to Senior Principal Toxicology Scientist - Cambridge - BenevolentAI
-
Principal Scientist
6 days ago
Cambridge, United Kingdom CY Partners Full time**Principal Scientist - Protein Expression** **Cambridgeshire Based** **£60,000 - £75,000 + Bonus + Excellent Benefits** Are you an expert in using insect cell culture for protein/enzyme production? Would you like to work for an exciting early-stage biotechnology company, supporting their novel assay platforms? My client is a Cambridge based...
-
Principal Scientist
5 hours ago
Cambridge, United Kingdom TEC PARTNERS LIMITED Full timeTEC partners are working with a rapidly growing company that provides instruments and specialist consumables for the global pharmaceutical and academic research community. Their novel single cell analysis systems can lead to a life-changing medicine. Based in Cambridge as Principal Scientist you will have the opportunity to develop technology that enables...
-
Senior/principal Scientist
6 days ago
Cambridge, United Kingdom Science Solutions Recruitment Ltd Full timeA growing Cambridge-based biotechnology company is seeking a Senior/Principal Scientist with experience in protein science and high-throughput assay development to join their team focused on the development of novel therapeutics. In this role, you will lead drug discovery projects, performing protein production, purification and protein aggregation assays,...
-
Medical Research Scientist
4 weeks ago
Cambridge, Cambridgeshire, United Kingdom Healthcare Businesswomen's Association Full timeJob Title: Medical Research ScientistAbout the Job: The Healthcare Businesswomen's Association seeks a highly skilled Medical Research Scientist to join our team. This is an exciting opportunity to apply your expertise in clinical pathology and toxicological safety to contribute to the development of new drugs.Key Responsibilities:Assess the effects of small...
-
Principal Biochemical Assay Scientist
4 days ago
Cambridge, United Kingdom Newton Colmore Consulting Ltd Full timePrincipal Biochemical Assay Scientist - Biotech A pioneer of biotechnology products in Cambridge are looking for a principal-level biochemical assay scientist to complement their research team. This is an excellent opportunity where you will be able to make a real difference with your work, developing products that aim to improve the patient's life, taking...
-
Cambridge, United Kingdom Reed Scientific Full time**About the Roles**: - First-hand practical experience of either manual/automated patch-clamp is required for these appointments. - Knowledge of standard laboratory instruments and common laboratory procedures is essential, preferably with some exposure to software used for electrophysiological experiments and familiarity with plate-based assay...
-
Principal Scientist
19 hours ago
Cambridge, United Kingdom Newton Colmore Consulting Ltd Full timePrincipal Scientist - Industrial Biotechnology R&D - Cambridge Newton Colmore Consulting is working with a biotechnology innovator in Cambridge and is searching for a principal scientist to join their team. The principal scientist will be charged with leading technological developments on novel solutions to several bioprocessing and industrial...
-
Principal Scientist, Biology
1 week ago
Cambridge, Cambridgeshire, United Kingdom TRIMTECH Therapeutics Limited Full timePrincipal Scientist Discovery Biology Salary: Competitive salary and benefits package, related to experience & qualifications TRIMTECH therapeutics, a rapidly growing well-funded and vibrant early-stage biotech based in Cambridge, UK, is expanding its team. You will have a key role in assay biology, screening, and managing partner collaborations...
-
Principal Scientist Hair Care Products
16 hours ago
Cambridge, United Kingdom RHL Full timeThis is a great opportunity for a Principal level Scientist to become Head of Hair Science and Claims with a global company with a strong brand, based just outside of Cambridge in the product R&D Facility. The Head of Hair Science and Claims will lead a team of scientists and working with marketing managers, project managers, engineers, and external...
-
Principal Bioinformatics Scientist
18 hours ago
Cambridge, United Kingdom CK GROUP Full timeCK Group are currently recruiting for a Principal Bioinformatics Scientist to join an early-stage drug development company based in Cambridge on a permanent basis. Hybrid working is available for this role. **The Company**: Our client has built a leading platform for the discovery and development of first-in-class, small molecule drugs that selectively...
-
Preclinical Programme Manager
1 month ago
Cambridge, United Kingdom Walker Cole International Full timeWalker Cole International is searching for a Preclinical Programme Manager to join an industry leading Biotechnology Company based in Cambridge. As a Preclinical Programme Manager you will be responsible for strategic assessment and development of therapies in the group discovery portfolio.Your responsibilities will be:Set the strategy of study design and...
-
Senior Scientist
4 months ago
Cambridge, United Kingdom Singular: Building Brilliant Biotechs Full timeSenior Formulations Scientist // Gene Therapy // Nanoparticle // Cambridge You are a project leading formulations scientist with a deep understanding of nanoparticle design for drug delivery systems. You have designed nanoparticles that deliver gene therapies (e.g. RNAs, DNAs, or even AAVs). Why have you developed this expertise? Is it to design therapies...
-
Senior Scientist
2 months ago
Cambridge, United Kingdom Singular: Building Brilliant Biotechs Full timeSenior Scientist // Microfluidics // CMC // Drug Delivery // Nanoparticle // CambridgeYou are a project leading nanoparticle scientist with a deep understanding of microfluidics, formulations, and CMC / process development.Why have you developed this expertise? Is it to design targeted therapies for patients suffering from real unmet need?We are working with...
-
Senior Scientist
5 months ago
Cambridge, United Kingdom Singular: Building Brilliant Biotechs Full timeSenior Formulations Scientist // Gene Therapy // Nanoparticle // Cambridge You are a project leading formulations scientist with a deep understanding of nanoparticle design for drug delivery systems. You have designed nanoparticles that deliver gene therapies (e.g. RNAs, DNAs, or even AAVs).Why have you developed this expertise? Is it to design therapies...
-
Senior Scientist
4 months ago
Cambridge, United Kingdom Singular: Building Brilliant Biotechs Full timeSenior Formulations Scientist // Gene Therapy // Nanoparticle // Cambridge You are a project leading formulations scientist with a deep understanding of nanoparticle design for drug delivery systems. You have designed nanoparticles that deliver gene therapies (e.g. RNAs, DNAs, or even AAVs).Why have you developed this expertise? Is it to design therapies...
-
Senior Scientist
4 months ago
Cambridge, United Kingdom Singular: Building Brilliant Biotechs Full timeSenior Formulations Scientist // Gene Therapy // Nanoparticle // Cambridge You are a project leading formulations scientist with a deep understanding of nanoparticle design for drug delivery systems. You have designed nanoparticles that deliver gene therapies (e.g. RNAs, DNAs, or even AAVs).Why have you developed this expertise? Is it to design therapies...
-
Cambridge, United Kingdom TEC PARTNERS LIMITED Full timeMy client, an award-winning spin-out from the University of Cambridge, with their breakthrough technology combining synthetic biology focusing on a scalable technology platform capable of producing consistent batches of mammalian cells. This potential willunlock a new generation of medicine and will allow the research and drug development sectors to work...
-
Senior Scientist
2 months ago
Cambridge, United Kingdom Singular: Building Brilliant Biotechs Full timeJob Description Senior Formulations Scientist // Gene Therapy // Nanoparticle // Cambridge You are a project leading formulations scientist with a deep understanding of nanoparticle design for drug delivery systems. You have designed nanoparticles that deliver gene therapies (e.g. RNAs, DNAs, or even AAVs). Why have you developed this expertise? Is it to...
-
Principal Scientist Discovery Biology
1 week ago
Cambridge, United Kingdom TRIMTECH Therapeutics Limited Full timeRole DetailsJob Title: Principal Scientist Discovery BiologyLocation: TRIMTECH therapeutics, The Milner Centre, Cambridge CB2 0AW, UK.Salary: Competitive salary and benefits package, related to experience & qualifications OverviewTRIMTECH therapeutics, a rapidly growing well-funded and vibrant early-stage biotech based in Cambridge, UK,...
-
Principal Scientist Discovery Biology
1 week ago
Cambridge, United Kingdom TRIMTECH Therapeutics Limited Full timeRole DetailsJob Title: Principal Scientist Discovery BiologyLocation: TRIMTECH therapeutics, The Milner Centre, Cambridge CB2 0AW, UK.Salary: Competitive salary and benefits package, related to experience & qualifications OverviewTRIMTECH therapeutics, a rapidly growing well-funded and vibrant early-stage biotech based in Cambridge, UK,...
Senior Principal Toxicology Scientist
6 months ago
Reporting to the VP DMPK and Safety, you will be an experienced highly motivated toxicologist, joining a small team responsible for leading the safety studies and strategy in support of Benevolent’s drug discovery and development portfolio. You will be skilled in providing clear and constructive guidance based on prior experience to Principal and Senior Scientists. You will have proven ability to positively influence strategy and project direction across the pipeline phases though strong interpersonal skills and clearly presented rationale.
With hybrid working from home and our London or Cambridge offices, you will be a core member of drug discovery project teams, working as the safety point of contact to progress programs from early discovery to the clinic.
Responsibilities
As the lead toxicologist, you will work within the DMPK and Safety department to define safety and toxicology strategies for the portfolio from TID to the clinic. For targets, you will lead, perform and review target safety assessments, and provide mitigation strategies using data from standard toxicological assays, bespoke approaches and in silico tools to elucidate mechanistic understanding. Based on the outcomes of target safety assessments, you will develop target de-risking strategies for new projects entering the portfolio. You will ensure the appropriate toxicology screening strategies are applied to predict, assess and mitigate target- and drug-related safety risks across the portfolio. You will develop and review study protocols and reports in association with CROs, ensuring that all critical studies are completed with quality work and within established timelines, supporting your team in their own study oversight. You will be responsible for the analysis, interpretation and presentation of toxicology data to project teams, updating risk assessments and applying knowledge and experience to impact project decisions. Able to respond to emerging data in preclinical studies , putting risks in context and providing positioning and mitigation strategies. Provide clear and constructive guidance based on prior experience to Principal and Senior Scientists. You will use your experience of in vitro toxicology studies to review new and current CROs providing nonclinical study services to BAIWe are looking for:
BSc/MSc/PhD in toxicology, pharmacology, biochemistry or a related discipline 10+ years’ experience working in the field of toxicology, with detailed working knowledge across a range of disease areas. Extensive experience in successfully leading, managing and developing staff Must have demonstrable experience of hands-on assessment of the safety of targets prior to entry into the portfolio, and in devising screening strategies to predict, assess and mitigate safety risks. An understanding of in vitro to in vivo translation of potential toxicities and implications for human safety. Ability to positively influence project direction though strong interpersonal skills. Someone with excellent communication, collaboration and organisational skills Wide range of experience as a safety lead in multifunction project teams A track record of contributing to successful drug discovery and development programs, ideally across pipeline stages,with experience of late stage regulatory non clinical safety packages, supporting IB, CTA, Pre IND. Experience within silico and in vitro safety assessment leading to an in-depth knowledge of discovery toxicology, and experience designing and critically evaluating results of exploratory toxicology studies. Hands-on experience with Lhasa Ltd NEXUS platform.