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Senior Bioinformatician in Immune Single Cell Genomics

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Oxford, United Kingdom University of Oxford Full time
Department of Paediatrics, Oxford Vaccine Group, Churchill Hospital, Oxford About the role The Oxford Vaccine Group (OVG) has an exciting opportunity for a Senior Bioinformatician in Immune Single Cell Genomics to work on two affiliated projects examining the immune response to vaccination funded by the MRC/UKRI and the Chan Zuckerberg Initiative. These projects involve (1) profiling the intra-lymph node dynamics of vaccine response in individuals of Black and Asian ancestry and in younger and older adults through the Lymph nodE single-cell Genomics AnCestrY (LEGACY) Network and (2) the Immune Memory and Mechanisms of Protection from Vaccines (IMMPROVE) consortium headed by Prof Teresa Lambe OBE and Prof Paul Klenerman, which will include spatial transcriptomic analysis on tissues from vaccinated humans and animals. As the postholder you will join the groups of Prof Katrina Pollock and Prof Teresa Lambe at the Oxford Vaccine Group, at The Oxford Vaccine Group, and Dr Nicholas Provine at the Pandemic Sciences Institute. The efficient development of vaccines effective against global and emerging pathogens relies on an improved understanding of the mechanisms and factors that govern vaccine responsiveness, including early adjuvant-dependent inflammatory events and variables such as age and environmental influences. Dissecting vaccine responsiveness is further complicated by the spectrum of immune cell types involved, but the advent of high-resolution profiling technologies along with developments for the use of human lymph nodes ex vivo and their in vivo sampling through fine needle aspiration present a tangible solution. This role meets the criteria for a UK Skilled Worker visa. About you This position is offered full-time on a fixed-term contract initially for two years with the possibility to extend provided further external funding is available. About the department