Biomarker Scientist

1 week ago

Slough, United Kingdom Next-Link Full time
The Biomarker AssaySciences group is positioned within Early Clinical Development andTranslational Science (ECD&TS) which as a departmentprovides strategy and support in integratedpharmacokinetics/pharmacodynamics and DMPK biomarker analysisimmunogenicity safety clinical development and regulatoryactivities throughout the lifespan of projects from targetidentification through to clinical studies of diversepharmacological candidates including novel chemical biological andgene therapyderived assets. The Biomarker Assay Sciences groupoperates and collaborates closely with colleagues across theorganization to support bioanalysis and biomarker activities in theprogression from research into theclinic.
TheBiomarker Assay Sciences group is looking for a high caliberscientist to join the team to support clinical transcriptomics as aSubject Matter Expert. The successful applicant will be responsiblefor planning and technical oversight of Biomarker Transcriptomicsactivities outsourced to CROs. They will also have the opportunityto expand their skills and work flexibly on labbased projects inthe Biomarker Assay Sciences team alongside biomarker specialistsin the Immunohistochemistry Flow Cytometry Ligand Binding and LCMSfields. The required candidate should have a strong scientificbackground good written and verbal communication skills and behighly selfmotivated with a proven ability to multitask effectivelyand adapt to meet the demands of a fastpaced matrixteamenvironment.
Therole is based in the UK inSlough.
Youwill have the opportunity to work in a crossfunctional settingacross multidisciplinary projects and teams and make meaningfulcontributions to the biomarker and bioanalytical strategies acrossUCB s portfolio through the lens of cuttingedge science technologyand enriching interactions with scientists with widerangingexpertise.

RequirementsRoleandResponsibilities:
As a Subject Matter Expert support clinical transcriptomicsoutsourced activities from a planning and technical perspectivesand ensure timely delivery of highquality fitforpurpose assays androbustdata.
Conduct and support sample analysis quality control datainterpretation andreporting.
Maintain up to date knowledge of new and emerging techniques andapproaches relevant to the transcriptomics and biomarkerfields.
Where appropriate support the development of biomarker assays inthelaboratories.
Ensure compliance with all health and safetyregulations.

Skillsand experiencerequired

Candidates should have a BSc or higher academic qualification in abiological discipline with good theoretical understanding of theprincipals of molecular biology and transcriptomics (in particularRNA sequencing and RTqPCR) and the application to biomarkeranalysis in clinicalstudies.
Practical experience of the complete workflow for RNA sequencingexperiments from sample extraction library preparation and qualitycontrol sequencing runs includingtroubleshooting.
Practical experience in Molecular Biology methods including RNAextraction from a variety of biofluids and tissue matrices primerand probe design quantitative PCR (realtime and/or ddPCR) and dataanalysis.
Excellent organisation skills and attention to detail essentialalongside enthusiasm to strengthen existing workflows andreporting
Clear grasp of context of use (linking biomarker assay requirementsto the usage of the datagenerated)
Demonstrated ability to work flexibly in a dynamic environment tomeet project needs and timelines with minimalsupervision
Ability to work in a matrix team and communicate in a clear andtimely manner with a wide range of internal and externalstakeholders.
Adaptable to changing project and organizational priorities alignedwith departmentalneeds
Preferred
Experience of working in a pharmaceutical drug discovery anddevelopmentenvironment.
Experience of Protein analysis usingOLINK
Experience working with Contract Research Organisations (CROs) tooversee method development validation and/or sample analysis toagreeddeadlines.
Experience in tissue and biofluid collection handling and storagein clinicalsettings.
Experience of working with human tissue under the directives of theHuman Tissue Act (HTA) and experience of working with samples andstudies under GCPcompliance
Practical experience in any of the following techniques would be anadvantage: histology and immunohistochemistry Immunoassay andligand binding assays Flow cytometry assaysLCMS.

Role and Responsibilities: As a Subject Matter Expert, supportclinical transcriptomics outsourced activities from a planning andtechnical perspectives and ensure timely delivery of high-qualityfit-for-purpose assays and robust data. Conduct and support sampleanalysis, quality control, data interpretation and reporting.Maintain up to date knowledge of new and emerging techniques andapproaches relevant to the transcriptomics and biomarker fields.Where appropriate, support the development of biomarker assays inthe laboratories. Ensure compliance with all health and safetyregulations. Skills and experience required Candidates should havea BSc or higher academic qualification in a biological disciplinewith good theoretical understanding of the principals of molecularbiology and transcriptomics (in particular RNA sequencing andRT-qPCR), and the application to biomarker analysis in clinicalstudies. Practical experience of the complete workflow for RNAsequencing experiments, from sample extraction, library preparationand quality control, sequencing runs, including troubleshooting.Practical experience in Molecular Biology methods, including RNAextraction from a variety of biofluids and tissue matrices, primerand probe design, quantitative PCR (real-time and/or ddPCR) anddata analysis. Excellent organisation skills and attention todetail essential, alongside enthusiasm to strengthen existingworkflows and reporting, Clear grasp of context of use (linkingbiomarker assay requirements to the usage of the data generated)Demonstrated ability to work flexibly in a dynamic environment tomeet project needs and timelines with minimal supervision Abilityto work in a matrix team and communicate in a clear and timelymanner with a wide range of internal and external stakeholders.Adaptable to changing project and organizational priorities,aligned with departmental needs Preferred Experience of working ina pharmaceutical drug discovery and development environment.Experience of Protein analysis using O-LINK Experience working withContract Research Organisations (CROs) to oversee methoddevelopment, validation and/or sample analysis to agreed deadlines.Experience in tissue and biofluid collection, handling and storagein clinical settings. Experience of working with human tissue underthe directives of the Human Tissue Act (HTA), and experience ofworking with samples and studies under GCP compliance Practicalexperience in any of the following techniques would be anadvantage: histology and immunohistochemistry, Immunoassay andligand binding assays, Flow cytometry assays, LC-MS.

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