Kidney Research UK PhD studentship: Enzymatic conversion of blood group antigens in human kidneys

Found in: Talent UK C2 - 1 week ago


Cambridge, United Kingdom University of Cambridge Full time

Applications are invited for a 3-year PhD studentship funded by Kidney Research UK under the supervision of Dr Sarah Hosgood. The studentship will be based in the University of Cambridge Department of Surgery on the Cambridge Biomedical Campus. The proposed start date is 1 October 2024.

In kidney transplantation, blood group compatibility is a major barrier to donor¿recipient matching. Patients with more restrictive blood types like type O or B often wait twice as long for a kidney compared to patients with blood group A. Longer waiting times are associated with poorer outcome and a higher chance of patient death. To overcome this barrier, a major research theme of our group is the use of novel machine perfusion technology for the enzymatic conversion of blood group A and B kidneys to O-type. This work has already received media attention: .

This studentship builds upon our group's successful initial findings that bacterial enzymes can remove ABO blood group antigens from the vasculature of human kidneys. With this studentship we aim to explore three key concepts with the aim of bridging this basic research to a stronger position for clinical application:

Assessing the efficacy of a new enzyme, FucOB, to convert human type O kidneys to a rare Bombay phenotype Understanding the kinetics of blood group antigen re-emergence after enzyme treatment Using an ABO-incompatible (ABOi) model in human kidneys to explore the pathophysiology of hyperacute antibody-mediated rejection.

Interested candidates are encouraged to read the following recent publication from our group:

The funds for this post are available for 3 years. Funding will cover the student's stipend and tuition fees at the UK rate. Non-UK applicants will be considered only if they can fund the overseas fees differential or if they are awarded a suitable scholarship.

We have a strong focus on translational research. You will work alongside world-leading academics and clinicians on research that could have real-world impact and meaningful patient benefit. You will also have access to training courses and events at the University and on the Biomedical Campus, as well as taught modules and lectures in relevant subjects.

Interested candidates should visit the University's Postgraduate Funding Search for more detailed information. The listing for this opportunity can be found here:

Applications must be made via the University Applicant portal: .

Informal enquiries can be addressed to Dr Sarah Hosgood, .

Application related enquiries should go to

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.


  • Phd Studentship

    5 days ago


    Cambridge, United Kingdom University of Cambridge Full time

    Applications are invited for a 3-year PhD studentship funded by Kidney Research UK under the supervision of Dr Sarah Hosgood. The studentship will be based in the University of Cambridge Department of Surgery on the Cambridge Biomedical Campus. The proposed start date is 1 October 2024. - Assessing the efficacy of a new enzyme, FucOB, to convert human type O...

  • Phd Studentship

    14 hours ago


    Cambridge, United Kingdom University of Cambridge Full time

    Applications are invited for a 4 year PhD studentship at the MRC Toxicology Unit, University of Cambridge under the supervision of James Thaventhiran and Klaus Okkenhaug (Department of Pathology). **Project** Immunotherapy toxicity is mediated by the activity of T lymphocyte clones that are driven by specific antigenic targets. The Medical Research...


  • Cambridge, United Kingdom University of Cambridge Full time

    Applications are invited for a 4 year PhD studentship at the MRC Toxicology Unit, University of Cambridge. This studentship is fully funded by the MRC Integrative Toxicology Training Partnership (ITTP). **Project** The Medical Research Council Toxicology Unit is an internationally renowned institution focused on mechanistic insights into toxicology and...


  • Cambridge, United Kingdom University of Cambridge Full time

    Applications are invited for a 4 year PhD studentship at the MRC Toxicology Unit, University of Cambridge, under the supervision of Kiran Patil and Sarah Aitken. The studentship is funded by the MRC Integrative-Toxicology Training Partnership (ITTP) with AstraZeneca as industrial partner. **Project** The efficacy and side effects of various drugs have been...

  • Phd Studentships

    6 days ago


    Cambridge, United Kingdom University of Cambridge Full time

    The Department of Pathology has an excellent reputation in pure biological and biomedical research and is offering four fully funded* studentships from October 2023 to work with one of the Research Group Leaders in this large and vibrant Department. Funding* will cover the student's stipend at the current Research Council rate and University Fees....


  • Cambridge, United Kingdom University of Cambridge Full time

    Applications are invited for a fully-funded 3-year studentship based in the Department of Pathology at the University of Cambridge under the supervision of Prof Nicholas Coleman and Dr Anton Enright. **Project title: Investigating Alternative Splicing As A Driver Mechanism And Therapeutic Target In Squamous Cell Carcinoma** Squamous cell carcinomas (SCCs)...

  • PhD Studentship

    Found in: beBee jobs GB - 2 weeks ago


    Cambridge, Cambridgeshire, United Kingdom University of Cambridge Full time

    Applications are invited for a PhD student to work on machine-learning guided and verifiably correct code generation.Creating optimised libraries is a difficult and time-consuming task, requiring significant manual engineering effort. This process must be repeated for each new processor to take advantage of additional features, especially when it implements...

  • EPSRC FIBE3 CDT PhD studentships

    Found in: Talent UK C2 - 1 week ago


    Cambridge, United Kingdom University of Cambridge Full time

    We have funding for a number of 4-year PhDs, in collaboration with industry, on net zero infrastructure and built environment under the four following themes: Current and disruptive technologies Circularity and whole life approach AI, digitalisation and data Risk-based systems thinking and connectivity Studentships are fully-funded (fees and...

  • Postdoctoral Research Associate

    Found in: Talent UK C2 - 1 week ago


    Cambridge, United Kingdom University of Cambridge Full time

    The Rayner and Deane Laboratories at the Cambridge Institute for Medical Research are recruiting a Postdoctoral Research Associate to work on a project that explores the function of a multi-gene family that is expanded in the genomes of Plasmodium Vivax and other related neglected human malaria parasites. The project builds on a recent publication that...


  • Cambridge, Cambridgeshire, United Kingdom University of Cambridge Full time

    We have funding for a number of 4-year PhDs, in collaboration with industry, as part of our EPSRC Centre for Doctoral Training in Future Infrastructure and Built Environment: Unlocking Net Zero (FIBE3 CDT), under the four following themes: Current and disruptive technologies Circularity and whole life approach Risk-based systems thinking and connectivity...

  • Postdoctoral Research Associate

    Found in: beBee jobs GB - 1 week ago


    Cambridge, Cambridgeshire, United Kingdom University of Cambridge Full time

    The Rayner and Deane Laboratories at the Cambridge Institute for Medical Research are recruiting a Postdoctoral Research Associate to work on a project that explores the function of a multi-gene family that is expanded in the genomes of Plasmodium Vivax and other related neglected human malaria parasites. The project builds on a recent publication that...

  • Research Associate in TCR repertoire analysis in cancer

    Found in: beBee jobs GB - 2 weeks ago


    Cambridge, Cambridgeshire, United Kingdom University of Cambridge Full time

    OverviewThe Blundell lab at the University of Cambridge is seeking a candidate for a postdoctoral position to investigate the use of T-cell receptor repertoire analysis for improving the detention of cancers from a blood sample. This is part of a large programme of research funded by the Alliance for Cancer Early Detection (ACED). We are an interdisciplinary...

  • Research Group Leader

    15 hours ago


    Cambridge, United Kingdom Medical Research Council Full time

    To direct an internationally competitive research programme within the Neurobiology Division of the MRC Laboratory of Molecular Biology (LMB) **Main duties/ Key responsibilities**: - To develop and lead a programme of research addressing fundamental aspects of neurobiology in health or diseases. - To recruit and supervise a small team of PhD Students and...

  • Research Associate in TCR repertoire analysis in cancer

    Found in: beBee S GB - 2 weeks ago


    Cambridge, United Kingdom University of Cambridge Full time

    Overview The Blundell lab at the University of Cambridge is seeking a candidate for a postdoctoral position to investigate the use of T-cell receptor repertoire analysis for improving the detention of cancers from a blood sample. This is part of a large programme of research funded by the Alliance for Cancer Early Detection (ACED). We are an...


  • Cambridge, United Kingdom University of Cambridge Full time

    AHRC Collections & Communities in the East of England Collaborative Doctoral Partnership (CDP) Start date: 1st October 2024 (fixed term for 4 years) Interviews will take place online on Tuesday 11 June. The University Museum of Zoology and Cambridge University Herbarium have exceptional collections from South Asia and the Mascarene Islands (taken to...

  • Postdoctoral Research Associate

    Found in: beBee S GB - 2 weeks ago


    Cambridge, United Kingdom University of Cambridge Full time

    The Rayner and Deane Laboratories at the Cambridge Institute for Medical Research are recruiting a Postdoctoral Research Associate to work on a project that explores the function of a multi-gene family that is expanded in the genomes of Plasmodium Vivax and other related neglected human malaria parasites. The project builds on a recent publication that...

  • Research Associate in TCR repertoire analysis in cancer

    Found in: Talent UK C2 - 1 week ago


    Cambridge, United Kingdom University of Cambridge Full time

    Project The central aim of the project is to investigate whether one can identify differences in the TCR repertoire of patients with IDH1 mutant gliomas from IDH1 null gliomas and from healthy controls by leveraging sequence specific information. The project will involve analysis of large sequencing datasets of TCR repertoires generated from peripheral...


  • Cambridge, United Kingdom University of Cambridge Full time

    A fully paid PhD studentship is offered at the Cambridge University Engineering Department in the area of nuclear reactor core analysis methods development. It is offered under Industrial Cooperative Awards in Science & Technology (iCASE) scheme of the UK Engineering and Physical Sciences Research Council (EPSRC) in collaboration with EDF Energy, the owner...


  • Cambridge, United Kingdom University of Cambridge Full time

    Come and join us in a small but passionate team in the Office of the School of Technology where we work together to propose, consult and implement policies and procedures across our Departments and Institute. Your role will be focused on education matters and PhD studentship funding within the School of Technology. It will involve working closely with the...


  • Cambridge, United Kingdom University of Cambridge Full time

    Would you like to help build the University of Cambridge's AI for science community? The Accelerate Programme for Scientific Discovery is a high-profile Cambridge University initiative promoting the use of machine learning to tackle major scientific challenges. Working across disciplines within the University, Accelerate is advancing research at the...