Post Doctoral Scientist

1 month ago

Reading, United Kingdom Pharmiweb Full time

Proclinical is working with a pharmaceutical organisation who are seeking a motivated Post Doctoral Scientist to join their team in Reading. In this role, you will be involved in high-impact research projects from discovery to advanced clinical development of Antibody-Drug Conjugates (ADCs). Your work will support the creation of mechanistic PKPD, population PK, and systems pharmacology models for ADCs, contributing to transformative advancements in the field.

Responsibilities:

  • Establish a comprehensive and flexible framework (Clinical Utility Index) for modeling ADC PKPD and the Exposure-Response relationship in both preclinical and clinical settings.
  • Determine the appropriate dose and regimen to achieve a better therapeutic index and understand preliminary dosing requirements.
  • Develop a cellular mathematical model with a deep understanding of physiochemical properties, target product profiles, and the mechanism of action of ADC components (mAb, linker, payload, and conjugated ADCs).
  • Assess the molecule's therapeutic index by evaluating its affinity and half-life.
  • Potentially expand research to other antibody conjugates, such as siRNA conjugates (ARCs) or Radioimmuno conjugates (RICs).

Key Skills and Requirements:

  • PhD in Pharmacometrics, Pharmaceutical/Biomedical Sciences, Computational Sciences, Engineering, or a related field.
  • Experience with relevant software such as R, Monolix, NONMEM, MATLAB, or similar.
  • Background in QSP, PK/PD, exposure-response modeling, or other modeling & simulation disciplines.
  • Self-directed and highly motivated with a desire to learn new techniques and pursue research and publication goals.
  • Excellent communication skills (oral and written) with presentation experience and a strong publication record.
  • Proficient in data analysis and reporting.
  • Understanding of pharmacokinetics and/or pharmacodynamic principles.


If you are having difficulty in applying or if you have any questions, please contact Joshua Bye at joshua.bye@proclinical.com

Apply Now:

If you are interested in learning more or applying to this exciting opportunity, please complete the form below and attach a copy of your CV. Alternatively, for further details or to talk directly to a life sciences recruitment specialist, please request a call back at the top of this page.

Proclinical is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Proclinical is acting as an Employment Agency in relation to this vacancy.

  • Post Doctoral Scientist

    1 month ago

    Reading, United Kingdom Proclinical Staffing Full time

    Proclinical is working with a pharmaceutical organisation who are seeking a motivated Post Doctoral Scientist to join their team in Reading. In this role, you will be involved in high-impact research projects from discovery to advanced clinical development of Antibody-Drug Conjugates (ADCs). Your work will support the creation of mechanistic PKPD, population...

  • PK/PD Scientist

    2 weeks ago

    Reading, Reading, United Kingdom CK Group Full time

    PK/PD Scientist (Post-Doctoral) RoleCK Group is seeking a highly skilled PK/PD Scientist (Post-Doctoral) to join a leading pharmaceutical company in Bracknell, UK. This contract-based role offers a unique opportunity to contribute to high-impact research endeavors in the field of Antibody Drug Conjugates (ADC).Key Responsibilities:Develop and implement...

  • Post-doctoral Research Assistant

    3 weeks ago

    Reading, United Kingdom University of Reading Full time

    Three-year post-doctoral research assistant role within the School of Psychology and Clinical Language Sciences at the University of Reading.Applications are invited for a full-time Post-Doctoral Research Assistant in Psychology to join Dr Katie Gray’s Social Vision Group at the University of Reading, to work on a Leverhulme Trust funded research project...

  • Post-doctoral Research Assistant

    3 weeks ago

    Reading, United Kingdom University of Reading Full time

    Three-year post-doctoral research assistant role within the School of Psychology and Clinical Language Sciences at the University of Reading. Applications are invited for a full-time Post-Doctoral Research Assistant in Psychology to join Dr Katie Gray’s Social Vision Group at the University of Reading, to work on a Leverhulme Trust funded research project...

  • Pharmaceutical Research Scientist

    1 week ago

    Reading, Reading, United Kingdom CK Group Full time

    PK/PD Scientist (Post-Doctoral) RoleWe are seeking a highly skilled PK/PD Scientist (Post-Doctoral) to join our team at CK Group. As a key member of our research team, you will play a crucial role in advancing our understanding of pharmacokinetics and pharmacodynamics in the development of Antibody Drug Conjugates (ADCs).Key Responsibilities:Develop and...

  • Post-doctoral Research Assistant

    5 months ago

    Reading, United Kingdom University of Reading Full time

    The University of Reading is seeking to recruit an enthusiastic and ambitious researcher to work on the Climate Change Impact on Midlatitude Cyclone Intensity, Tracks and Impacts (CLIM-CITI) project. Fixed term post, up to 24 months. Extratropical cyclones in the North Atlantic storm track region cause significant economic damage each year due to their...

  • PhD Research Scientist

    4 weeks ago

    Reading, Reading, United Kingdom Pharmiweb Full time

    Pharmacometrician for ADC ResearchProclinical is working with a pharmaceutical organisation who are seeking a motivated Post Doctoral Scientist to join their team in Reading. In this role, you will be involved in high-impact research projects from discovery to advanced clinical development of Antibody-Drug Conjugates (ADCs). Your work will support the...

  • PhD Research Scientist

    4 weeks ago

    Reading, Reading, United Kingdom Pharmiweb Full time

    Pharmacometrician for ADC ResearchProclinical is working with a pharmaceutical organisation who are seeking a motivated Post Doctoral Scientist to join their team in Reading. In this role, you will be involved in high-impact research projects from discovery to advanced clinical development of Antibody-Drug Conjugates (ADCs). Your work will support the...

  • Doctoral Research Office Administrator

    1 day ago

    Reading, United Kingdom University of Reading Full time

    The Doctoral and Researcher College acts as hub for all doctoral level activity at the University as well as providing support and training for doctoral researchers. Within the Doctoral and Researcher College, the Doctoral Research Office provides a support service to all current doctoral research students and networks widely across the University...

  • Research Scientist

    3 weeks ago

    Reading, Reading, United Kingdom University of Reading Full time

    Job Title: Research ScientistWe are seeking a highly skilled and motivated Research Scientist to join our team at the University of Reading. The successful candidate will be responsible for conducting research to better understand the atmospheric circulation and its response to tipping points in the North Atlantic climate system.About the RoleThis is an...

  • Research Scientist

    3 weeks ago

    Reading, Reading, United Kingdom University of Reading Full time

    Job Title: Research ScientistWe are seeking a highly skilled and motivated Research Scientist to join our team at the University of Reading. The successful candidate will be responsible for conducting research to better understand the atmospheric circulation and its response to tipping points in the North Atlantic climate system.About the RoleThis is an...

  • Clinical Scientist and Medical Physics Expert

    1 month ago

    Reading, Reading, United Kingdom NHS Full time

    Career Opportunity for Clinical Scientist and Medical Physics ExpertWe are seeking a highly skilled Clinical Scientist and Medical Physics Expert to join our Radiation Protection team at the Royal Berkshire NHS Foundation Trust.The successful candidate will provide a radiation safety service to the Trust and other organisations with radiation safety...

  • European Field Application Scientist

    2 weeks ago

    Reading, Reading, United Kingdom Lifelancer Full time

    Job Title: European Field Application ScientistMolecular Devices is a leading life science solutions provider of high-performance bioanalytical measurement systems, software, and consumables. We are seeking a highly skilled European Field Application Scientist to join our team.Job Summary:The European Field Application Scientist will be responsible for...

  • European Field Application Scientist

    2 weeks ago

    Reading, Reading, United Kingdom Lifelancer Full time

    Job Title: European Field Application ScientistMolecular Devices is a leading life science solutions provider of high-performance bioanalytical measurement systems, software, and consumables. We are seeking a highly skilled European Field Application Scientist to join our team.Job Summary:The European Field Application Scientist will be responsible for...

  • Research Scientist

    6 days ago

    Reading, Reading, United Kingdom University of Reading Full time

    We are seeking a talented postdoctoral scientist to carry out research to better understand how the atmospheric circulation responds to tipping points in the North Atlantic climate system. This research is a component of the international research projects, TipESM and OptimESM. The post will be based in the National Centre for Atmospheric Science, within the...

  • Specialist Doctor in Gastroenterology

    5 days ago

    Reading, Reading, United Kingdom Royal Berkshire NHS Foundation Trust Full time

    This is a permanent post for a Specialist Doctor in Gastroenterology to join the existing team at the Royal Berkshire NHS Foundation Trust.The department aims to deliver excellent clinical care in the field of Gastroenterology and Endoscopy.Main DutiesProvide general gastroenterology clinical care and endoscopic services to patients at the Royal Berkshire...

  • Clinical Scientist and Medical Physics Expert

    2 weeks ago

    Reading, Reading, United Kingdom Royal Berkshire NHS Foundation Trust Full time

    About the RoleWe are seeking a highly motivated and experienced Clinical Scientist and Medical Physics Expert to join our Radiation Protection team at the Royal Berkshire NHS Foundation Trust.The successful candidate will have a strong background in radiation protection and medical physics, with expertise in diagnostic radiology and a deep understanding of...

  • Clinical Scientist and Medical Physics Expert

    1 month ago

    Reading, Reading, United Kingdom NHS Full time

    Career Opportunity for Clinical Scientist and Medical Physics ExpertWe are seeking a highly skilled Clinical Scientist and Medical Physics Expert to join our Radiation Protection team at the Royal Berkshire NHS Foundation Trust.The successful candidate will provide a radiation safety service to the Trust and other organisations with radiation safety...

  • Clinical Scientist and Medical Physics Expert

    1 month ago

    Reading, Reading, United Kingdom NHS Full time

    Career Opportunity for Clinical Scientist and Medical Physics ExpertWe are seeking a highly skilled Clinical Scientist and Medical Physics Expert to join our Radiation Protection team at the Royal Berkshire NHS Foundation Trust.The successful candidate will provide a radiation safety service to the Trust and other organisations with radiation safety...

  • Clinical Scientist and Medical Physics Expert

    3 weeks ago

    Reading, Reading, United Kingdom NHS Full time

    Career Opportunity for Clinical Scientist and Medical Physics ExpertWe are seeking a highly skilled Clinical Scientist and Medical Physics Expert to join our Radiation Protection team at the Royal Berkshire NHS Foundation Trust.The successful candidate will provide a radiation safety service to the Trust and other organisations with radiation safety...