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Bioinformatician - Translational Biology

3 months ago

London, United Kingdom Engitix Full time
Your mission

We are seeking a Bioinformatician to join the Data Sciences team and work closely with the Translational Biology team focusing on biomarker discovery for fibrotic liver diseases.  

The successful candidate will be involved in the analysis of a complex novel dataset, integrating clinical with molecular datasets to identify potential biomarkers of fibrotic liver diseases in addition to working across the portfolio to develop better therapies, as part of a highly collaborative and multidisciplinary team of scientists. The ideal candidate will be self-motivated and proactive, and demonstrate strong team spirit, enthusiasm, confidence, and dedication. Key responsibilities: 

  • Partner with Engitix scientists and external collaborators to draft and implement analysis plans, and iteratively deliver actionable biological insights and visualizations
  • Refine key questions, clearly articulate concepts, needs, and potential solutions, and effectively communicate results to diverse teams
  • Establish, test, and improve analysis pipelines
  • Develop innovative analytical approaches and analysis plans integrating, analyzing, and interpreting high-dimensional multimodal datasets
  • Ensure data and analytics integrity through best practices in FAIR data, reproducibility, and documentation
Your profile

As well as strong communication, organizational, and time management skills, you will have:  

  • A postgraduate degree in Bioinformatics, Computational Biology, Biostatistics or equivalent 
  • Strong programming/scripting skills in R and/or Python 
  • Previous experience of performing bulk transcriptomics analysis and at least one of:-
    • scRNAseq and or spatial transcriptomics
    • Molecular imaging, including spatial proteomics
    • Quantitative proteomics, including familiarity with mass spectrometry technologies (e.g., LFQ and TMT)
    • Multi-omics and data integration
  • Foundational skills in statistics and/or machine learning, including experience with methods such as survival analysis, regression analysis, dimensionality reduction, classification, and clustering
Desirable:
  • Experience working in a cross-functional team in Oncology or Fibrosis 
  • Experience working with cloud services (e.g., AWS) and workflow languages (e.g., NextFlow)
Why us?

  • Be part of a motivated, dynamic team supporting cutting edge drug discovery 
  • Constant opportunities to learn, grow, and explore the many opportunities for data science to have impact on drug discovery and development
  • State of the art offices at The Westworks, White City London 
  • Competitive reward package including private medical insurance, bonus, pension, and much more 
Join us today in our mission to create a healthier future for patients with life-threatening diseases such as fibrosis and cancer.About us

We are pioneering the way to significantly improve the lives of fibrosis and solid tumour patients and their families. Through our unique understanding of the extra-cellular matrix (ECM), and our world-class technology and approach, we are unlocking insights and enabling the generation of new, advanced therapeutics.

At Engitix, relationships are the foundation of accomplishment. 
We are one team working together in service of our mission to significantly improve the lives of fibrosis and solid tumour patients and their families. We care deeply about what we do and the impact we will have. Our dedication to be passionate, committed and respectful is at the heart of how we operate. It’s our DNA.