Leader of DMPK and Physical Sciences, London

5 days ago

London, UK, United Kingdom myGwork Full time

This inclusive employer is a member of myGwork – the largest global platform for the LGBTQ+ business community.

Leader of DMPK and Physical Sciences, London

Isomorphic Labs is a new Alphabet company that is reimagining drug discovery through a computational- and AI-first approach.

We are on a mission to accelerate the speed, increase the efficacy and lower the cost of drug discovery. You'll be working at the cutting edge of the new era of 'digital biology' to deliver a transformative social impact for the benefit of millions of people.

Come and be part of a multi-disciplinary team driving groundbreaking innovation and play a meaningful role in contributing towards us achieving our ambitious goals, while being a part of an inspiring, collaborative and entrepreneurial culture.

Your impact

This is an exciting opportunity to work closely with world leading AI and ML experts to develop imaginative new ways to predict ADMET and human dose to drive projects forward. You will have accountability for all the ADMET strategies from early Drug Discovery through to Candidate Selection and ultimately to Clinical Phase work across numerous therapeutic areas.

We are seeking a candidate who is highly experienced, with significant management experience, working across drug discovery projects, driving them to Candidate Selection and preferably to clinical phases of development.

What you will do
  • Set the company DMPK strategy across the project portfolio
  • Lead a small team of DMPK scientists to deliver on Drug Discovery projects
  • Work with CROs to deliver the highest quality ADMET data and reports
  • Distil ADMET data into actionable insights for project leaders, project team members, and potential collaborators
  • Be closely integrated in projects to provide strategic input into the project direction
  • Prepare relevant internal and regulatory documentation for preclinical and clinical work
  • Apply PK-PD modelling work to set dosing strategies for in vivo efficacy models, and to provide early human dose projections
  • Work cross functionally with Medicinal Chemistry, Biology, and Technology groups
Skills and qualifications Essential:
  • BSc, MSc or PhD in Biochemistry/Chemistry/Pharmacology/Pharmacokinetics and likely be highly experienced (>10 years) in the pharmaceutical industry
  • Expert knowledge are DMPK concepts such as Tier 1/2 ADMET assays, Transporters, Drug Metabolising Enzymes and Transformations, IVIVC/IVIVE, Pharmacokinetics, PK-PD relationships, mechanistic and allometric scaling approaches to Human Dose Projections
  • Proven track record of influence on projects such as de-risking strategies, anticipating longer term issues, solving ADMET issues and driving change in Medicinal Chemistry SAR strategies
  • Experience of working in multiple therapeutic areas and by multiple routes of administration
  • Experience working with Toxicology, Translational, Formulation, Clinical Pharmacology in setting clinical strategies
  • Experience leading the DMPK group/department
  • Driven and focussed mindset to achieve the goal of Candidate delivery in the most efficient manner through robust discussions with key stakeholders and project leaders
  • Dynamic, agile, and flexible individual who can work across therapeutic areas, and multi-disciplinary teams
  • Experience working with and assisting CROs in acquiring high quality ADMET data in a timely manner
  • Collaborative and inclusive mindset to partner across teams to drive shared learning
Nice to have:
  • Experience working for a CRO providing ADMET services
  • Knowledge/Concept of computational chemistry machine learning modelling
  • Good understanding of Medicinal Chemistry concepts and comfortable discussing small molecule approaches and strategies
  • Experience working with Data Science groups in setting up assay templates for ingestion of ADMET data

Culture and values

What does it take to be successful at IsoLabs? It's not about finding people who think and act in the same way, but we do have some shared values:

Thoughtful
Thoughtful at Iso is about curiosity, creativity and care. It is about good people doing good, rigorous and future-making science every single day.

Brave
Brave at Iso is about fearlessness, but it’s also about initiative and integrity. The scale of the challenge demands nothing less.

Determined
Determined at Iso is the way we pursue our goal. It’s a confidence in our hypothesis, as well as the urgency and agility needed to deliver on it. Because disease won’t wait, so neither should we.

Together
Together at Iso is about connection, collaboration across fields and catalytic relationships. It’s knowing that transformation is a group project, and remembering that what we’re doing will have a real impact on real people everywhere.


Creating an inclusive company

We realise that to be successful we need our teams to reflect and represent the populations we are striving to serve. We’re working to build a supportive and inclusive environment where collaboration is encouraged and learning is shared. We value diversity of experience, knowledge, backgrounds and perspectives and harness these qualities to create extraordinary impact.

We are committed to equal employment opportunities regardless of sex, race, religion or belief, ethnic or national origin, disability, age, citizenship, marital, domestic or civil partnership status, sexual orientation, gender identity, pregnancy or related condition (including breastfeeding) or any other basis protected by applicable law. If you have a disability or additional need that requires accommodation, please do not hesitate to let us know.


Hybrid working

It’s hugely important for us to be able to share knowledge and establish relationships with each other, and we find it easier to do this if we spend time together in person. This is why we’ve decided to follow a hybrid model, and for full time positions we would require you to be able to come into the office 3 days a week (currently Tue, Wed, and one other day depending on which team you’re in). For part time positions this may vary. As an equal opportunities employer we are committed to building an equal and inclusive team. If you have additional needs that would prevent you from following this hybrid approach, we’d be happy to talk through these if you’re selected for an initial screening call.

Please note that when you submit an application, your data will be processed in line with our privacy policy.


>> Click to view other open roles at Isomorphic Labs

  • Data Science Leader

    1 month ago

    London,, UK, United Kingdom Anson McCade Full time

    Data Science LeaderLondon - hybrid working A global consulting firm renowned for its expertise in providing tailored solutions to complex business challenges. With a focus on driving measurable results and fostering innovation, this company collaborates closely with clients across various industries to navigate critical issues and achieve sustainable growth....

  • Science Technician

    4 weeks ago

    London, UK, United Kingdom Harris Federation Full time

    Working With UsAre you ready to change the world? Harris Science Academy East London is a new, small school with big ambitions. We are in the top 3% of schools nationally for year on year improvement and in the top 20 most improved schools in London. Join us on our mission to help our children become leaders in their chosen fieldwith many leading in science...

  • Director Data Science

    2 weeks ago

    London,, UK, United Kingdom Omnis Partners Full time

    Data Science & Analytics Director - Insurance Domain CONSULTING £150k - £200k Hybrid / LondonOur client is a global software solutions business, with a strong focus on engineering, looking to pivot and transition into advisory and consulting.Following the appointment of an industry-recognised Director of Data & AI, they are looking to hire further senior...

  • Director Data Science

    2 weeks ago

    London,, UK, United Kingdom Omnis Partners Full time

    Data Science & Analytics Director - Pharmaceutical OR Healthcare Domain CONSULTING £150k - £200k Hybrid / LondonOur client is a global software solutions business, with a strong focus on engineering, looking to pivot and transition into advisory and consulting.Following the appointment of an industry-recognised Director of Data & AI, they are looking to...

  • Science teacher

    4 weeks ago

    London, UK, United Kingdom Tradewind Recruitment Full time

    Tradewind are recruiting a science teacher to work in the Greenwich area of west London. The Science teacher must have specialism in either Biology, Chemistry and Physics but also be able to comfortably cover the whole syllabus or had experience teaching it before. The post will begin in September 2024 and last up until the end of the academic year 2025 with...

  • First-Class Physics Graduate

    1 day ago

    East London, UK, United Kingdom Ribbons and Reeves Limited Full time

    First-Class Physics Graduate | Hackney | September 2024Are you a top-tier Physics graduate from a leading UK university, eager to launch your teaching career in a prestigious London secondary school and sixth form? Join us in Hackney for a transformative role starting in September 2024. Ribbons & Reeves is partnering with a renowned secondary school in...

  • Science Teacher

    1 month ago

    London, UK, UK, United Kingdom Wayman Recruitment Group Full time

    Chemistry/Physics Specialist for Deputy Science VacancyWayman Education is delighted to be recruiting for a Chemistry/Physics Specialist Deputy Science Vacancy at an Outstanding school in Wimbledon, Merton, South London.About The SchoolThis is a fantastic opportunity to join a thriving and supportive science department at an Outstanding school. The school is...

  • Physics Teacher

    2 days ago

    London,, UK, United Kingdom Henry Blue Part time

    I am currently working with an Ofsted Outstanding College in London who are looking for a Partv Time Physics Teacher to join them in the new academic year.This is a superb opportunity for the right candidate to teach A level Physics in one of London’s best sixth form colleges, with a salary depending on experience.Teaching takes place in small groups with...

  • Medical Sales, Medical Physics

    2 days ago

    London,, UK, United Kingdom Helix Medical Recruitment Ltd Full time

    As a Medical Sales Specialist for this global leader in medical dosimetry, radiotherapy and medical imaging QA & QC (quality testing) products, you'll support customers across the South UK.Consultative medical sales of high-quality medical dosimetry and quality control instruments for medical imaging and radiotherapy systems via new and existing...

  • Head of Marketing Science

    2 weeks ago

    London,, UK, United Kingdom Cornucopia IT Resourcing Full time

    Head of Marketing ScienceGreater London / HybridAre client is an international agency providing data driven marketing solutions. They are looking for a Head of Marketing Science to join them.The role is a rare opportunity to be right at the forefront of media and brand analytics, leveraging a leading global platform and working with a regional Data Science...

  • Physics Academic Mentor

    3 days ago

    East London, UK, United Kingdom Ribbons and Reeves Limited Full time

    Physics Academic Mentor | Stratford, Newham Are you looking to support students from less fortunate backgrounds find their passion for Physics as a Physics Academic Mentor? Have you recently graduated from a Top UK University in Physics and want to inspire students to follow your footsteps? I am currently working with an inclusive, diverse and high...

  • Head of Social Sciences Vacancy In East London

    1 month ago

    London, UK, UK, United Kingdom Wayman Recruitment Group Full time

    You will be joining an established Social Sciences department where you will be able to teach to KS3/4/5. This position would suit an experienced Social Sciences Teacher seeking an opportunity for career development. Head of Social Sciences Role Full time position Teaching KS3, KS4 and KS5 Tower Hamlets Starting January/April MPS1 - UPS3 Salary With Outer...

  • Physical Education Teacher

    3 weeks ago

    London, South East, UK, United Kingdom HAYS Full time

    Permanent Physical Education Teacher Job / September 2024 Start / Bishop Challoner Catholic School / E1 0LB Physical Education Teacher JobSalary: Inner London Pay Scale – MPS/UPS (£34,502 to £56,959)Contract Type: Permanent, Full TimeTo Start: September 2024Location: 352 Commercial Road London, E1 0LB, London Borough of Tower HamletsThere is a wave of...

  • Head of Science

    4 weeks ago

    London, UK, United Kingdom GSL Education Full time

    Location: HaringeySalary: M1 - M6Start Date: September 2024Contract Type: Full-time Exciting Opportunity for a Head of Science in Haringey! Are you a passionate and dedicated science educator looking to take the next step in your career? We are seeking a dynamic Head of Science to lead our science department at a vibrant secondary school for girls in...

  • Physical Education Teacher

    1 month ago

    London,, UK, United Kingdom Bishop Challoner Catholic School Full time

    Physical Education Teacher JobSalary: Inner London Pay Scale – MPS/UPS (£34,502 to £56,959)Contract Type: Permanent, Full TimeTo Start: September 2024 Location: 352 Commercial Road London, E1 0LB, London Borough of Tower HamletsThere is a wave of change and improvement at Bishop Challoner, can you be part of our journey of improvement?The Governors seek...

  • Recruitment Consultant

    1 month ago

    London,, UK, United Kingdom Pure Life Sciences Full time

    Recruitment Consultant – Perm, Life SciencesPure Healthcare & Pure Life Sciences are seeking a Recruitment Consultant to join our rapidly expanding Life Sciences desk.About us:Established in 2020, Pure Healthcare Group (PHG) is a vibrant, dynamic, passionate, and successful healthcare recruitment business. We are now expanding our divisions and have...

  • Science Teacher Vacancy In Newham

    1 month ago

    London, UK, UK, United Kingdom Wayman Recruitment Group Part time

    Wayman Education is looking for a Science Teacher for an Outstanding Independent School in NewhamWayman Education is looking for a Science Teacher for an Outstanding Independent School in Newham. This is a full time position to start from January and the school is looking for a Science teacher to teach to KS3/4. Applications from NQT's and experienced...

  • Science Teacher

    3 weeks ago

    London, UK, United Kingdom Remedy Recruitment Group Full time

    Science Teacher - Immediate interviews - September Start Role: Science Teacher Start: September Start Location Wandsworth, Greater London Rates: £180 - £220 per day Industry: Education Are you a qualified Science Teacher? Are you passionate about teaching Science? Do you wish to work in a new vibrant school?Science Teacher- The RoleIf so then we would be...

  • Physics ECT Vacancy In Richmond, South-West London

    1 month ago

    London, UK, UK, United Kingdom Wayman Recruitment Group Full time

    You will be joining a dynamic Physics department where you will be able to teach to KS3/4/5. This position would suit either an ECT Physics ECT or a more experienced Physics ECT seeking an opportunity for professional development. Physics ECT Role Full time position Teaching KS3, KS4 and KS5 Richmond September 2024 MPS1 - UPS3 Salary With Outer London...

  • Science Teacher Needed In Wandsworth

    1 month ago

    London, UK, UK, United Kingdom Wayman Recruitment Group Full time

    Are you an experienced and passionate Science Teacher seeking a new opportunity in Wandsworth?About Us: Wayman Education is a trusted recruitment partner dedicated to connecting outstanding educators with top-tier schools. We are currently collaborating with a prestigious school in Wandsworth to fill a vacancy for a Science Teacher.Position: Science...