Director Pharmacology

24 hours ago

Remote work Remote work, UK, United Kingdom headcount AG Full time
*REMOTE POSITION*

We are seeking a motivated and energetic individual with a scientific background to help drive drug discovery activities. The Senior Pharmacology Lead (Director) will be responsible for managing nonclinical pharmacology studies aimed at selecting and profiling new drug candidates in the therapeutic area of HAE (Genetic/Rare). This position requires a background in pharmacology and drug discovery, along with strong hands-on skills managing outsourced studies. If you are a creative and innovative professional, passionate about identifying new preclinical candidates, this could be the role for you

Role and Responsibilities
  • Provide pharmacological and technical expertise for selecting and characterizing new drug candidates with external partners (CROs or academic collaborators).
  • Design, manage, analyze, and report on:
    • In vitro biochemical and functional assays
    • Mechanism of action studies
    • In vivo efficacy studies
    • Translational biomarker studies
  • Report and communicate results to direct manager and cross-functional project teams.
  • Act as the primary contact/study monitor with selected CROs or academic collaborators (discussing budgets, timelines, study plans, results, and reports).
  • Contribute to the selection of the best drug candidates to move forward into development.
  • Assist in the preparation of scientific and technical dossiers for regulatory purposes.
Profile
  • PhD in (Medical) Biology, Pharmacy, or Biopharmaceutical Sciences.
  • Deep knowledge of assays, models, and technologies for pharmacological characterization of small molecules in vitro and in vivo.
  • At least 5 years of pharmaceutical industry experience in the design and conduct of pharmacology studies, and managing CROs.
  • Extensive experience in analyzing pharmacology data sets, interpreting, and presenting results.
  • Strong contributions to the receptor pharmacology field (GPCR) required; experience in innovative biomarker detection technologies is a plus.
  • Fluency in writing drug discovery and pharmacology sections in regulatory documents such as IBs, INDs, NDAs, MAAs.

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