Research Associate in Chemical Biology in
1 week ago
**Role**:
Applications are invited for two Postdoctoral Researcher positions to work on the structural and chemical enzymology of the enzymes of glycobiology, in the domains of human genetic disease, cancer, viral invasion and bacterial pathogenesis. The work is funded by an ERC-Synergy grant to York, Barcelona and Leiden and is available for up to 36 months. You will be supervised by Professor Gideon Davies, FRS, and will work in the ERC-Synergy team in the York Structural Biology Laboratory, within Chemistry.
**Key responsibilities**:
- Mammalian and insect cell gene expression and protein production for structural and kinetic analyses
- Enzyme production using both bacterial systems
- Enzyme characterisation and inhibition
- Ligand-bound structure solution by X-ray crystallography: crystallisation, data collection and structure solution / refinement / deposition
- Single particle CryoEM using the in-house Glacios system and eBIC
**Skills, Experience & Qualification needed**:
- A first degree in Chemistry, Biochemistry or related area
- A PhD in Biochemistry, Chemistry, Molecular biology, Microbiology or related area
- Enthusiasm for carbohydrate-active enzymes, including structures and mechanisms
- Skill in gene expression, preferably in mammalian or insect cell systems
- Skill in CryoEM or X-ray crystallography or activity-based probes
- Knowledge of work in the Davies Research group (from wider reading) and an understanding of the work of ERC-Synergy partners Carme Rovira in Barcelona and Hermen Overkleeft in Leiden
- Well-developed analytical skills, experience of undertaking high quality research in relevant areas
**Interview date**: To be confirmed
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