Research Assistant

3 days ago

Cambridge, United Kingdom University of Cambridge Full time

Research Assistant / Research Associate in Genetic interrogation of the ubiquitin-proteasome system (Fixed Term)

**Department of Medicine**

**Salary**: Research Assistant £34,610 - £35,608 Research Associate £37,694 - £46,049

We are looking for a talented scientist to join the laboratory led by Dr. Richard Timms based in the Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID). The Timms lab applies the latest genetic technologies to identify novel functions for human genes. Our focus is the ubiquitin-proteasome system, where we seek to (1) identify substrates for E3 ubiquitin ligases, (2) characterise the molecular features that enable selective substrate recognition, and (3) explore how these processes are corrupted in the context of viral infection and autoimmune disease.

We exploit a range of high-throughput genetic screening techniques to uncover novel pathways regulated by the ubiquitin system. We measure the stability of GFP-tagged proteins by performing expression screens in human cells, using either a human ORFeome library comprising ~14,000 barcoded human ORFs or custom libraries generated through microarray-based oligonucleotide synthesis, and identify the cellular machinery involved by combining these expression screens with loss-of-function CRISPR/Cas9 screens. Detailed follow-up of individual pathways of interest is achieved through a variety of standard genetic and biochemical approaches.

**Recent publications relevant to this position include**:
Timms RT et al. (2023) Defining E3 ligase substrate relationships through multiplex CRISPR screening. Nature Cell Biology, 25: 1535-1545.

Timms RT et al. (2019) A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. Science, 365 (6448): eaaw4912.

Koren I, Timms RT et al. (2018) The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons. Cell, 173 (7): 1622-1635.

**Closing date: 31st October 2025**

Benefits include generous maternity/paternity leave, flexible working and funds for returning carers and other family-friendly schemes.

**Key information**:
**Department/location**:
Department of Medicine

**Salary**:
£33,002-£46,049

**Reference**:
RC47658

**Category**:
Research

**Date published**:
17 October 2025

**Closing date**:
17 October 2025

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